21st-century hazards of smoking and benefits of cessation in the United States.
paper
Cited
Public
Unavailable
- Authors
- Jha, Prabhat; Ramasundarahettige, Chinthanie; Landsman, Victoria; Rostron, Brian; Thun, Michael; Anderson, Robert N; McAfee, Tim; Peto, Richard
- Year
- 2013
- Journal
- The New England journal of medicine
- PMID
- 23343063
- DOI
- 10.1056/NEJMsa1211128
BACKGROUND: Extrapolation from studies in the 1980s suggests that smoking causes 25% of deaths among women and men 35 to 69 years of age in the United States. Nationally representative measurements of the current risks of smoking and the benefits of cessation at various ages are unavailable. METHODS: We obtained smoking and smoking-cessation histories from 113,752 women and 88,496 men 25 years of age or older who were interviewed between 1997 and 2004 in the U.S. National Health Interview Survey and related these data to the causes of deaths that occurred by December 31, 2006 (8236 deaths in women and 7479 in men). Hazard ratios for death among current smokers, as compared with those who had never smoked, were adjusted for age, educational level, adiposity, and alcohol consumption. RESULTS: For participants who were 25 to 79 years of age, the rate of death from any cause among current smokers was about three times that among those who had never smoked (hazard ratio for women, 3.0; 99% confidence interval [CI], 2.7 to 3.3; hazard ratio for men, 2.8; 99% CI, 2.4 to 3.1). Most of the excess mortality among smokers was due to neoplastic, vascular, respiratory, and other diseases that can be caused by smoking. The probability of surviving from 25 to 79 years of age was about twice as great in those who had never smoked as in current smokers (70% vs. 38% among women and 61% vs. 26% among men). Life expectancy was shortened by more than 10 years among the current smokers, as compared with those who had never smoked. Adults who had quit smoking at 25 to 34, 35 to 44, or 45 to 54 years of age gained about 10, 9, and 6 years of life, respectively, as compared with those who continued to smoke. CONCLUSIONS: Smokers lose at least one decade of life expectancy, as compared with those who have never smoked. Cessation before the age of 40 years reduces the risk of death associated with continued smoking by about 90%.
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| Do Patients Reporting Fractures Experience Food Insecurity More Frequently Than the General Population? | Jella TK et al. | — | 2023 | → |
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| Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration. | Garza AP et al. | — | 2023 | → |
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| The smoking and vaping model, A user-friendly model for examining the country-specific impact of nicotine VAPING product use: application to Germany. | Sánchez-Romero LM et al. | — | 2023 | → |
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| What was the impact of tobacco taxes on smoking prevalence and coronary heart disease mortality in the United States -2005-2016, and did it vary by race and gender? | Cohen GH et al. | — | 2023 | → |
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| AKR1C1 as a Biomarker for Differentiating the Biological Effects of Combustible from Non-Combustible Tobacco Products. | Woo S et al. | — | 2017 | → |
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| Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE-deficient mice. | Yang HL et al. | — | 2017 | → |
| A pilot investigation of the impact of smoking cessation on biological age. | Lei MK et al. | — | 2017 | → |
| A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. | Jensen KP et al. | — | 2017 | → |
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| Availability, Sales, and Affordability of Tobacco Cessation Medicines in Kerala, India. | Sarma S et al. | — | 2017 | → |
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| Cost-Effectiveness of a Health System-Based Smoking Cessation Program. | Levy DE et al. | — | 2017 | → |
| Current smoking is associated with extracranial carotid atherosclerotic stenosis but not with intracranial large artery disease. | Ji R et al. | — | 2017 | → |
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| Development and evaluation of the See Me Smoke-Free multi-behavioral mHealth app for women smokers. | Gordon JS et al. | — | 2017 | → |
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| E-cigarette Use and Cigarette Smoking Cessation among Texas College Students. | Mantey DS et al. | — | 2017 | → |
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| Effect of Tobacco Smoking on The Clinical, Histopathological, and Serological Manifestations of Sjögren's Syndrome. | Stone DU et al. | — | 2017 | → |
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| Heat Maps of Hypertension, Diabetes Mellitus, and Smoking in the Continental United States. | Loop MS et al. | — | 2017 | → |
| Identifying demographic and psychosocial factors related to the escalation of smoking behavior among Mexican American adolescents. | Shete SS et al. | — | 2017 | → |
| Impact of Age at Smoking Initiation on Smoking-Related Morbidity and All-Cause Mortality. | Choi SH et al. | — | 2017 | → |
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| Lifestyles and Mortality in Taiwan: An 11-Year Follow-up Study. | Lin YH et al. | — | 2017 | → |
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| Moderators of smoking cessation outcomes in a randomized-controlled trial of varenicline versus placebo. | Littlewood RA et al. | — | 2017 | → |
| Naturally Segregating Variation at <i>Ugt86Dd</i> Contributes to Nicotine Resistance in <i>Drosophila melanogaster</i>. | Highfill CA et al. | — | 2017 | → |
| Number of Chronic Medical Conditions Fully Mediates the Effects of Race on Mortality; 25-Year Follow-Up of a Nationally Representative Sample of Americans. | Assari S | — | 2017 | → |
| Parsing disease-relevant protein modifications from epiphenomena: perspective on the structural basis of SOD1-mediated ALS. | Schmitt ND et al. | — | 2017 | → |
| Passive Smoking Is Not Associated with Risk of Intracranial Aneurysm Rupture in Nonsmoking Women. | Feng X et al. | — | 2017 | → |
| Perioperative Smoking Cessation and Clinical Care Pathway for Orthopaedic Surgery. | Truntzer J et al. | — | 2017 | → |
| Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies. | Pintarelli G et al. | — | 2017 | → |
| Preliminary evaluation of a telephone-based smoking cessation intervention in the lung cancer screening setting: A randomized clinical trial. | Taylor KL et al. | — | 2017 | → |
| Prevalence and patterns of tobacco smoking among Chinese adult men and women: findings of the 2010 national smoking survey. | Liu S et al. | — | 2017 | → |
| Prevalence of Tobacco Smoking and Factors Associated with the Initiation of Smoking among University Students in Dhaka, Bangladesh. | Hossain S et al. | — | 2017 | → |
| Protein Carbonylation in Human Smokers and Mammalian Models of Exposure to Cigarette Smoke: Focus on Redox Proteomic Studies. | Dalle-Donne I et al. | — | 2017 | → |
| Regretting Ever Starting to Smoke: Results from a 2014 National Survey. | Nayak P et al. | — | 2017 | → |
| Re: Modeling the Effects of E-cigarettes on Smoking Behavior: Implications for Future Adult Smoking Prevalence. | Soneji S et al. | — | 2017 | → |
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| Smoking at the time of diagnosis and mortality in cancer patients: What benefit does the quitter gain? | Tabuchi T et al. | — | 2017 | → |
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| Smoking-related general and cause-specific mortality in Estonia. | Kõks G et al. | — | 2017 | → |
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| Stakeholder Research Priorities for Smoking Cessation Interventions within Lung Cancer Screening Programs. An Official American Thoracic Society Research Statement. | Kathuria H et al. | — | 2017 | → |
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| The Application of a Decision-Theoretic Model to Estimate the Public Health Impact of Vaporized Nicotine Product Initiation in the United States. | Levy DT et al. | — | 2017 | → |
| The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. | van Waateringe RP et al. | — | 2017 | → |
| The earlier the better: health-related quality of life is inversely related to age of smoking cessation in older former Italian smokers. | Gasperini B et al. | — | 2017 | → |
| The life-course impact of smoking on hypertension, myocardial infarction and respiratory diseases. | Gao K et al. | — | 2017 | → |
| The long-term risk of smoking in diabetic patients with stable ischemic heart disease treated with intensive medical therapy and lifestyle modification. | Khan AA et al. | — | 2017 | → |
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| Trends in Tobacco Smoking among Czech School-aged Children from 1994 to 2014. | Salonna F et al. | — | 2017 | → |
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| Using SmartQuit®, an Acceptance and Commitment Therapy Smartphone application, to reduce smoking intake. | Singh S et al. | — | 2017 | → |
| Worsening Dietary and Physical Activity Behaviors Do Not Readily Explain Why Smokers Gain Weight After Cessation: A Cohort Study in Young Adults. | Tian J et al. | — | 2017 | → |
| "You've Come a Long Way, Baby": The Convergence in Age Patterns of Lung Cancer Mortality by Sex, United States, 1959-2013. | Rivadeneira NA et al. | — | 2017 | → |
| A comparison of five surveys that identify individuals at risk for airflow obstruction and chronic obstructive pulmonary disease. | Sogbetun F et al. | — | 2016 | → |
| Active Cigarette Smoking in Cognitively-Normal Elders and Probable Alzheimer's Disease is Associated with Elevated Cerebrospinal Fluid Oxidative Stress Biomarkers. | Durazzo TC et al. | — | 2016 | → |
| Acute stimulation of mesenchymal stem cells with cigarette smoke extract affects their migration, differentiation, and paracrine potential. | Wahl EA et al. | — | 2016 | → |
| Agmatine protects rat liver from nicotine-induced hepatic damage via antioxidative, antiapoptotic, and antifibrotic pathways. | El-Sherbeeny NA et al. | — | 2016 | → |
| Application of the Abridged SimSmoke model to four Eastern Mediterranean countries. | Levy DT et al. | — | 2016 | → |
| Can a Healthy Lifestyle Compress the Disabled Period in Older Adults? | Jacob ME et al. | — | 2016 | → |
| Cancer prevention as part of precision medicine: 'plenty to be done'. | Stewart BW et al. | — | 2016 | → |
| Cardiovascular toxicity of nicotine: Implications for electronic cigarette use. | Benowitz NL et al. | — | 2016 | → |
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| Chronic Bronchitis in Chronic Obstructive Pulmonary Disease. Magnifying Why Smoking Cessation Still Matters Most. | Rosenberg SR et al. | — | 2016 | → |
| Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema. | Qiu SL et al. | — | 2016 | → |
| Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases. | Passarelli MN et al. | — | 2016 | → |
| Cigarette smoking, comorbidity, and general health among survivors of adolescent and young adult cancer. | Kaul S et al. | — | 2016 | → |
| Comparative Effectiveness of Smoking Cessation Medications: A National Prospective Cohort From Taiwan. | Chang PY et al. | — | 2016 | → |
| Correlation of an epigenetic mitotic clock with cancer risk. | Yang Z et al. | — | 2016 | → |
| Current and cumulative night shift work and subclinical atherosclerosis: results of the Gutenberg Health Study. | Jankowiak S et al. | — | 2016 | → |
| Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma? | Bæk R et al. | — | 2016 | → |
| ["Do not do" also as regards tobacco]. | Olano-Espinosa E et al. | — | 2016 | → |
| Effect of a Digital Social Media Campaign on Young Adult Smoking Cessation. | Baskerville NB et al. | — | 2016 | → |
| Effect of smoking status on coronary artery disease among Chinese post-menopausal women. | Ma J et al. | — | 2016 | → |
| Effects of smoking and its cessation on creatinine- and cystatin C-based estimated glomerular filtration rates and albuminuria in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. | Ohkuma T et al. | — | 2016 | → |
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| Evaluation of a newly developed tobacco cessation program for people with disabilities. | King JL et al. | — | 2016 | → |
| Evaluation of Bar and Nightclub Intervention to Decrease Young Adult Smoking in New Mexico. | Kalkhoran S et al. | — | 2016 | → |
| Gauging the Effect of U.S. Tobacco Control Policies From 1965 Through 2014 Using SimSmoke. | Levy DT et al. | — | 2016 | → |
| Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis. | Chen LS et al. | — | 2016 | → |
| Global tobacco prevention and control in relation to a cardiovascular health promotion and disease prevention framework: A narrative review. | Carroll AJ et al. | — | 2016 | → |
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| Healthy lifestyle factors and incident heart disease and mortality in candidates for primary prevention with statin therapy. | Booth JN et al. | — | 2016 | → |
| Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. | Writing Group Members et al. | — | 2016 | → |
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| How Intravenous Nicotine Administration in Smokers Can Inform Tobacco Regulatory Science. | Jensen KP et al. | — | 2016 | → |
| How smoking affects the proportion of deaths attributable to obesity: assessing the role of relative risks and weight distributions. | Stokes A et al. | — | 2016 | → |
| Impact of changing US cigarette smoking patterns on incident cancer: risks of 20 smoking-related cancers among the women and men of the NIH-AARP cohort. | Freedman ND et al. | — | 2016 | → |
| Impact of Cigarette Smoking and Smoking Cessation on Life Expectancy Among People With HIV: A US-Based Modeling Study. | Reddy KP et al. | — | 2016 | → |
| Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD. | Morton RL et al. | — | 2016 | → |
| Implementation of Tobacco Dependence Treatment Programs in Oncology Settings. | Sarna L et al. | — | 2016 | → |
| Improving Quality of Care for Hospitalized Smokers with HIV: Tobacco Dependence Treatment Referral and Utilization. | Fitzgerald SA et al. | — | 2016 | → |
| Impulsivity and Stress Response in Nondependent Smokers (Tobacco Chippers) in Comparison to Heavy Smokers and Nonsmokers. | Carim-Todd L et al. | — | 2016 | → |
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| In the Clinic. Smoking Cessation. | Patel MS et al. | — | 2016 | → |
| Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development. | Jacob NT et al. | — | 2016 | → |
| Is smoking tobacco associated with psychotic experiences across racial categories in the United States? Findings from the Collaborative Psychiatric Epidemiological Surveys. | Oh HY et al. | — | 2016 | → |
| It's never too late: Smoking cessation after stereotactic body radiation therapy for non-small cell lung carcinoma improves overall survival. | Roach MC et al. | — | 2016 | → |
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| Measuring Burden of Unhealthy Behaviours Using a Multivariable Predictive Approach: Life Expectancy Lost in Canada Attributable to Smoking, Alcohol, Physical Inactivity, and Diet. | Manuel DG et al. | — | 2016 | → |
| Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel. | Jones DP et al. | — | 2016 | → |
| Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease. | Dumanski JP et al. | — | 2016 | → |
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| Regional variations in the economic burden attributable to excess weight, physical inactivity and tobacco smoking across British Columbia. | Krueger H et al. | — | 2016 | → |
| Smoking, alcohol and illicit drug use effects on survival in HIV-positive persons. | Petoumenos K et al. | — | 2016 | → |
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| Smoking and progression of diabetic nephropathy in patients with type 1 diabetes. | Feodoroff M et al. | — | 2016 | → |
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| Smoking Cessation for People Living With HIV/AIDS: A Literature Review and Synthesis. | Ledgerwood DM et al. | — | 2016 | → |
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| The fundamental importance of smoking cessation in those with premature ST-segment elevation acute myocardial infarction. | Rallidis LS et al. | — | 2016 | → |
| The Impact of Current Smoking and Smoking Cessation on Short-Term Morbidity Risk After Lumbar Spine Surgery. | Martin CT et al. | — | 2016 | → |
| The International Epidemiology of Lung Cancer: Latest Trends, Disparities, and Tumor Characteristics. | Cheng TY et al. | — | 2016 | → |
| The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial. | Wang Z et al. | — | 2016 | → |
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| Cigarette Smoking and Carotid Plaque Echodensity in the Northern Manhattan Study. | Yang D et al. | — | 2015 | → |
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| Trends in the Average Age of Quitting Among U.S. Adult Cigarette Smokers. | Schauer GL et al. | — | 2015 | → |
| Using Laplace Regression to Model and Predict Percentiles of Age at Death When Age Is the Primary Time Scale. | Bellavia A et al. | — | 2015 | → |