Distribution of alcohol dehydrogenase isoenzymes in the human liver acinus.
- Authors
- Maly, I P; Toranelli, M; Sasse, D
- Year
- 1999
- Journal
- Histochemistry and cell biology
- PMID
- 10403118
- DOI
- 10.1007/s004180050372
By the use of a newly developed technique of ultrathin-layer electrophoresis, class I and class II alcohol dehydrogenase activity could be demonstrated in microdissected samples of the periportal, intermediate, and perivenous zones of the liver acinus in men and women. It could be demonstrated that both classes exhibit low activity in the periportal zone. From there, a rising gradient in the direction of the perivenous end was apparent. This increase, however, was found to be significant only in women. The analysis of class I alcohol dehydrogenase isoenzymes showed that the expression of alpha-, beta-, and gamma-containing isoforms did not differ in relation to the intraacinar position. The constant proportions of the isoenzymes to the maxima and minima of the total alcohol dehydrogenase activity support the view that the adult liver-specific isoenzyme pattern is determined during postnatal development.
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In this knowledge base
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The alcohol dehydrogenase isoenzyme (ADH I) as a marker of intrahepatic cholestasis of pregnancy. | Piechota J et al. | — | 2022 | → |
| Activity of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in sera of patients with hepatitis C. | Jelski W et al. | — | 2018 | → |
| Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis. | Gao N et al. | — | 2018 | → |
| Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. | Ramadori P et al. | — | 2017 | → |
| Alcohol dehydrogenase and aldehyde dehydrogenase in malignant neoplasms. | Orywal K et al. | — | 2017 | → |
| Alcohol metabolism and oesophageal cancer: a systematic review of the evidence. | Matejcic M et al. | — | 2017 | → |
| Non-(13)CO2 targeted breath tests: a feasibility study. | Ruzsanyi V et al. | — | 2014 | → |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | — | 2012 | → |
| Alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in the sera of patients with esophageal cancer. | Jelski W et al. | — | 2009 | → |
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| Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases. | Jelski W et al. | — | 2008 | → |
| Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. | Jelski W et al. | — | 2008 | → |
| The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. | Jelski W et al. | — | 2008 | → |
| A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme. | Janecki DJ et al. | — | 2007 | → |
| High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease. | Westerlund M et al. | — | 2007 | → |
| Gender-related differences in hepatic activity of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in humans. | Chrostek L et al. | — | 2003 | → |
| Changes in the activity of alcohol dehydrogenase isoenzymes during the estrus cycle in the vagina of the rat. | Nowak C et al. | — | 2000 | → |