Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids.
paper
Cited
Public
Unavailable
- Authors
- Bacci, Alberto; Huguenard, John R; Prince, David A
- Year
- 2004
- Journal
- Nature
- PMID
- 15372034
- DOI
- 10.1038/nature02913
Neocortical GABA-containing interneurons form complex functional networks responsible for feedforward and feedback inhibition and for the generation of cortical oscillations associated with several behavioural functions. We previously reported that fast-spiking (FS), but not low-threshold-spiking (LTS), neocortical interneurons from rats generate a fast and precise self-inhibition mediated by inhibitory autaptic transmission. Here we show that LTS cells possess a different form of self-inhibition. LTS, but not FS, interneurons undergo a prominent hyperpolarization mediated by an increased K+-channel conductance. This self-induced inhibition lasts for many minutes, is dependent on an increase in intracellular [Ca2+] and is blocked by the cannabinoid receptor antagonist AM251, indicating that it is mediated by the autocrine release of endogenous cannabinoids. Endocannabinoid-mediated slow self-inhibition represents a powerful and long-lasting mechanism that alters the intrinsic excitability of LTS neurons, which selectively target the major site of excitatory connections onto pyramidal neurons; that is, their dendrites. Thus, modulation of LTS networks after their sustained firing will lead to long-lasting changes of glutamate-mediated synaptic strength in pyramidal neurons, with consequences during normal and pathophysiological cortical network activities.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic Tools in Rodents to Study Cannabinoid Functions. | Monory K et al. | β | 2026 | β |
| Abnormalities of the endocannabinoid system produce piercing nuclear hernias in migrating cerebral neurons. | Morozov YM et al. | β | 2025 | β |
| Cannabinoid Modulation of Excitability and Short-Term Neuronal Dynamics in the Dorsal and Ventral Hippocampus. | Tsotsokou G et al. | β | 2025 | β |
| Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation. | Loomba N et al. | β | 2025 | β |
| Deletion of Endocannabinoid Synthesizing Enzyme DAGLΞ± in Pcp2-Positive Cerebellar Purkinje Cells Decreases Depolarization-Induced Short-Term Synaptic Plasticity, Reduces Social Preference, and Heightens Anxiety. | Smith G et al. | β | 2025 | β |
| Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms. | Cole RH et al. | β | 2025 | β |
| Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter-3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex. | Somogyi P et al. | β | 2025 | β |
| The Endocannabinoid System in Retinal MΓΌller Glia: Lessons From Astrocyte Research. | Beriain S et al. | β | 2025 | β |
| The role of endocannabinoid signaling in the cytoskeleton functionality in migrating neurons. | Morozov YM et al. | β | 2025 | β |
| The steroid hormone 20-hydroxyecdysone induces lipophagy via the brain-adipose tissue axis by promoting the adipokinetic hormone pathway. | Li YX et al. | β | 2025 | β |
| Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders. | Kumar U | β | 2024 | β |
| Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence. | Rodrigues RJ et al. | β | 2024 | β |
| Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels. | Nguyen H et al. | β | 2024 | β |
| Interplay between endocannabinoid and endovanilloid mechanisms in fear conditioning. | BriΓ’nis RC et al. | β | 2024 | β |
| Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease. | Rathod SS et al. | β | 2024 | β |
| Astrocytes gate long-term potentiation in hippocampal interneurons | Shen W et al. | β | 2023 | β |
| Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment. | Scheyer A et al. | β | 2023 | β |
| Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective. | Oddi S et al. | β | 2023 | β |
| Endocannabinoid signaling in microglia. | Marinelli S et al. | β | 2023 | β |
| Endocannabinoid signaling in synaptic function. | Noriega-Prieto JA et al. | β | 2023 | β |
| Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges. | Hassan FU et al. | β | 2023 | β |
| Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons. | Steiger LJ et al. | β | 2023 | β |
| The Relationship Between Cannabinoids and Neural Oscillations: How Cannabis Disrupts Sensation, Perception, and Cognition. | Syed SA et al. | β | 2023 | β |
| Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans. | Pamplona FA et al. | β | 2022 | β |
| Anti-Nociceptive and Anti-Aversive Drugs Differentially Modulate Distinct Inputs to the Rat Lateral Parabrachial Nucleus. | Teuchmann HL et al. | β | 2022 | β |
| Mechanisms of endocannabinoid transport in the brain. | Kaczocha M et al. | β | 2022 | β |
| Special issue editorial: Cannabinoid signalling in the brain: New vistas. | Busquets-Garcia A et al. | β | 2022 | β |
| The synaptic lipidome in health and disease. | VallΓ©s AS et al. | β | 2022 | β |
| Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA. | Liang J et al. | β | 2021 | β |
| Cannabinoid Signaling in Auditory Function and Development. | Ghosh S et al. | β | 2021 | β |
| Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings. | Kesner AJ et al. | β | 2021 | β |
| CB1 receptor neutral antagonist treatment epigenetically increases neuropeptide Y expression and decreases alcohol drinking. | Dulman RS et al. | β | 2021 | β |
| Endocannabinoid-serotonin systems interaction in health and disease. | Colangeli R et al. | β | 2021 | β |
| Mechanisms of endocannabinoid control of synaptic plasticity. | Winters BL et al. | β | 2021 | β |
| Myrcene-What Are the Potential Health Benefits of This Flavouring and Aroma Agent? | Surendran S et al. | β | 2021 | β |
| Review of the Endocannabinoid System. | Lu HC et al. | β | 2021 | β |
| Targeting Endocannabinoid Signaling in the Lateral Habenula as an Intervention to Prevent Mental Illnesses Following Early Life Stress: A Perspective. | Shepard RD et al. | β | 2021 | β |
| Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system. | Jeremic D et al. | β | 2021 | β |
| Tonic Endocannabinoid Signaling Gates Synaptic Plasticity in Dorsal Raphe Nucleus Serotonin Neurons Through Peroxisome Proliferator-Activated Receptors. | Oubraim S et al. | β | 2021 | β |
| Cannabinoid Control of Olfactory Processes: The <i>Where</i> Matters. | Terral G et al. | β | 2020 | β |
| Cannabinoids, Endocannabinoids and Sleep. | Kesner AJ et al. | β | 2020 | β |
| Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina. | Vielma AH et al. | β | 2020 | β |
| Cannabinoids, TRPV and nitric oxide: the three ring circus of neuronal excitability. | Gambino G et al. | β | 2020 | β |
| Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration. | Morozov YM et al. | β | 2020 | β |
| Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, <i>Habrobracon hebetor</i>. | Yu K et al. | β | 2020 | β |
| Neurobiology of cannabinoid receptor signalingβ©. | Lutz B | β | 2020 | β |
| Protein Interactors and Trafficking Pathways That Regulate the Cannabinoid Type 1 Receptor (CB1R). | Fletcher-Jones A et al. | β | 2020 | β |
| Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory. | Oliveira da Cruz JF et al. | β | 2020 | β |
| Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies. | Reddy V et al. | β | 2020 | β |
| The Role of the Cannabinoid System in Opioid Analgesia and Tolerance. | Ozdemir E | β | 2020 | β |
| Absence of Entourage: Terpenoids Commonly Found in <i>Cannabis sativa</i> Do Not Modulate the Functional Activity of Ξ<sup>9</sup>-THC at Human CB<sub>1</sub> and CB<sub>2</sub> Receptors. | Santiago M et al. | β | 2019 | β |
| Cholinergic modulation of striatal nitric oxide-producing interneurons. | Melendez-Zaidi AE et al. | β | 2019 | β |
| Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system. | Wyrofsky RR et al. | β | 2019 | β |
| In vitro determination of the efficacy of illicit synthetic cannabinoids at CB<sub>1</sub> receptors. | Sachdev S et al. | β | 2019 | β |
| Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues. | Ruiz de Azua I et al. | β | 2019 | β |
| Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease. | Kind L et al. | β | 2019 | β |
| Cannabinoid-glutamate interactions and neural oscillations: implications for psychosis. | Sherif MA et al. | β | 2018 | β |
| Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. | Zou S et al. | β | 2018 | β |
| Cannabinoids and glial cells: possible mechanism to understand schizophrenia. | de Almeida V et al. | β | 2018 | β |
| Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons. | Stumpf A et al. | β | 2018 | β |
| CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice. | Subbanna S et al. | β | 2018 | β |
| CB<sub>1</sub> Receptor Signaling in the Brain: Extracting Specificity from Ubiquity. | Busquets-Garcia A et al. | β | 2018 | β |
| Endocannabinoids in Body Weight Control. | Horn H et al. | β | 2018 | β |
| Expression and localization of CB1R, NAPE-PLD, and FAAH in the vervet monkey nucleus accumbens. | Kucera R et al. | β | 2018 | β |
| Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. | Haj-Dahmane S et al. | β | 2018 | β |
| Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System. | Augustin SM et al. | β | 2018 | β |
| TRP Channels as Novel Targets for Endogenous Ligands: Focus on Endocannabinoids and Nociceptive Signalling. | Storozhuk MV et al. | β | 2018 | β |
| Cannabinoid Receptors Modulate Neuronal Morphology and AnkyrinG Density at the Axon Initial Segment. | Tapia M et al. | β | 2017 | β |
| Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research. | Ruggiero RN et al. | β | 2017 | β |
| Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. | Gantz SC et al. | β | 2017 | β |
| Synaptic functions of endocannabinoid signaling in health and disease. | Araque A et al. | β | 2017 | β |
| The CB1 Receptor as the Cornerstone of Exostasis. | Piazza PV et al. | β | 2017 | β |
| An Introduction to the Endogenous Cannabinoid System. | Lu HC et al. | β | 2016 | β |
| Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse. | Oliveira da Cruz JF et al. | β | 2016 | β |
| Cannabinoid Control of Learning and Memory through HCN Channels. | Maroso M et al. | β | 2016 | β |
| Cannabinoid receptor type-1: breaking the dogmas. | Busquets Garcia A et al. | β | 2016 | β |
| Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus. | Stempel AV et al. | β | 2016 | β |
| Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells. | Miraucourt LS et al. | β | 2016 | β |
| From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology. | Ligresti A et al. | β | 2016 | β |
| It's All in the Rhythm: The Role of Cannabinoids in Neural Oscillations and Psychosis. | Skosnik PD et al. | β | 2016 | β |
| Mechanisms contributing to prefrontal cortex maturation during adolescence. | Caballero A et al. | β | 2016 | β |
| Muscarinic Long-Term Enhancement of Tonic and Phasic GABA<sub>A</sub> Inhibition in Rat CA1 Pyramidal Neurons. | DomΓnguez S et al. | β | 2016 | β |
| The Hyperpolarization-Activated Cation Current Ih: The Missing Link Connecting Cannabinoids to Cognition. | Vargish GA et al. | β | 2016 | β |
| Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease. | Wyrofsky R et al. | β | 2015 | β |
| Endocannabinoid Regulation of Neuroendocrine Systems. | Tasker JG et al. | β | 2015 | β |
| GIRK Channel Plasticity and Implications for Drug Addiction. | Marron Fernandez de Velasco E et al. | β | 2015 | β |
| GIRK Channels: A Potential Link Between Learning and Addiction. | Tipps ME et al. | β | 2015 | β |
| Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. | Belluomo I et al. | β | 2015 | β |
| Self-regulation of adult thalamocortical neurons. | Kasten MR et al. | β | 2015 | β |
| The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission. | Rossi S et al. | β | 2015 | β |
| Ξ9-THC Disrupts Gamma (Ξ³)-Band Neural Oscillations in Humans. | Cortes-Briones J et al. | β | 2015 | β |
| Cannabinoid-dependent potentiation of inhibition at eye opening in mouse V1. | Garkun Y et al. | β | 2014 | β |
| Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. | Davis MP | β | 2014 | β |
| Disrupted gamma-band neural oscillations during coherent motion perception in heavy cannabis users. | Skosnik PD et al. | β | 2014 | β |
| Endocannabinoid modulation of cortical up-states and NREM sleep. | Pava MJ et al. | β | 2014 | β |
| Endogenous cannabinoid signaling at inhibitory interneurons. | Younts TJ et al. | β | 2014 | β |
| Epidemiological, neurobiological, and genetic clues to the mechanisms linking cannabis use to risk for nonaffective psychosis. | van Winkel R et al. | β | 2014 | β |
| Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice. | Subbanna S et al. | β | 2014 | β |
| Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition. | Li G et al. | β | 2014 | β |
| Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta. | Freestone PS et al. | β | 2014 | β |
| Impact of Cannabis Use on the Development of Psychotic Disorders. | Wilkinson ST et al. | β | 2014 | β |
| Interplay between synaptic endocannabinoid signaling and metaplasticity in neuronal circuit function and dysfunction. | Melis M et al. | β | 2014 | β |
| Neurophysiological evidence for the presence of cannabinoid CB1 receptors in the laterodorsal tegmental nucleus. | Soni N et al. | β | 2014 | β |
| Polarized cellular patterns of endocannabinoid production and detection shape cannabinoid signaling in neurons. | Ladarre D et al. | β | 2014 | β |
| Resting state functional magnetic resonance imaging reveals distinct brain activity in heavy cannabis users - a multi-voxel pattern analysis. | Cheng H et al. | β | 2014 | β |
| Revisiting enigmatic cortical calretinin-expressing interneurons. | Cauli B et al. | β | 2014 | β |
| Synaptic effects of cannabinoids: complexity, behavioral effects, and potential clinical implications. | Benarroch EE | β | 2014 | β |
| The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome. | Cea-Del Rio CA et al. | β | 2014 | β |
| Alterations of neocortical development and maturation in autism: insight from valproic acid exposure and animal models of autism. | Chomiak T et al. | β | 2013 | β |
| Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. | Subbanna S et al. | β | 2013 | β |
| CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses. | Younts TJ et al. | β | 2013 | β |
| Cannabinoids: well-suited candidates for the treatment of perinatal brain injury. | FernΓ‘ndez-LΓ³pez D et al. | β | 2013 | β |
| Firing statistics of inhibitory neuron with delayed feedback. I. Output ISI probability density. | Vidybida AK et al. | β | 2013 | β |
| The functional benefits of criticality in the cortex. | Shew WL et al. | β | 2013 | β |
| [ΒΉΒ²β΅I]SD-7015 reveals fine modalities of CBβ cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease. | Farkas S et al. | β | 2012 | β |
| Cannabinoid modulation of noradrenergic circuits: implications for psychiatric disorders. | Carvalho AF et al. | β | 2012 | β |
| Cellular neurochemical characterization and subcellular localization of phospholipase C Ξ²1 in rat brain. | MontaΓ±a M et al. | β | 2012 | β |
| Dose-related modulation of event-related potentials to novel and target stimuli by intravenous ΞβΉ-THC in humans. | D'Souza DC et al. | β | 2012 | β |
| Endocannabinoids and retrograde modulation of synaptic transmission. | Ohno-Shosaku T et al. | β | 2012 | β |
| Endocannabinoid signaling and synaptic function. | Castillo PE et al. | β | 2012 | β |
| Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex. | Kovacs FE et al. | β | 2012 | β |
| Family-based genome-wide association study of frontal ΞΈ oscillations identifies potassium channel gene KCNJ6. | Kang SJ et al. | β | 2012 | β |
| Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex. | Ma Y et al. | β | 2012 | β |
| Functional diversity on synaptic plasticity mediated by endocannabinoids. | Cachope R | β | 2012 | β |
| Identification of mRNA for endocannabinoid biosynthetic enzymes within hippocampal pyramidal cells and CA1 stratum radiatum interneuron subtypes using quantitative real-time polymerase chain reaction. | Merrill CB et al. | β | 2012 | β |
| K(+) channels: function-structural overview. | GonzΓ‘lez C et al. | β | 2012 | β |
| Pathological plasticity in fragile X syndrome. | Martin BS et al. | β | 2012 | β |
| Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. | Gyombolai P et al. | β | 2012 | β |
| The effect of chronic cannabinoids on broadband EEG neural oscillations in humans. | Skosnik PD et al. | β | 2012 | β |
| Type-1 cannabinoid receptor signaling in neuronal development. | Gaffuri AL et al. | β | 2012 | β |
| Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex. | George AL et al. | β | 2011 | β |
| Dual regulation of anterograde and retrograde transmission by endocannabinoids. | Iremonger KJ et al. | β | 2011 | β |
| Dynamic modulation of short-term synaptic plasticity in the auditory cortex: the role of norepinephrine. | Salgado H et al. | β | 2011 | β |
| Layer-specific noradrenergic modulation of inhibition in cortical layer II/III. | Salgado H et al. | β | 2011 | β |
| Modulation of the serotonin system by endocannabinoid signaling. | Haj-Dahmane S et al. | β | 2011 | β |
| Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | Yoshino H et al. | β | 2011 | β |
| State-dependent, bidirectional modulation of neural network activity by endocannabinoids. | Piet R et al. | β | 2011 | β |
| Supply and demand for endocannabinoids. | Alger BE et al. | β | 2011 | β |
| Target-dependent control of synaptic inhibition by endocannabinoids in the thalamus. | Sun YG et al. | β | 2011 | β |
| Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. | Bennion D et al. | β | 2011 | β |
| Architecture of cannabinoid signaling in mouse retina. | Hu SS et al. | β | 2010 | β |
| BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex. | Lemtiri-Chlieh F et al. | β | 2010 | β |
| Brief bursts self-inhibit and correlate the pyramidal network. | Berger TK et al. | β | 2010 | β |
| Cannabinoid modulation of limbic forebrain noradrenergic circuitry. | Carvalho AF et al. | β | 2010 | β |
| Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics. | Grimsey NL et al. | β | 2010 | β |
| Cannabinoids and the immune system: an overview. | Tanasescu R et al. | β | 2010 | β |
| Cannabinoids excite circadian clock neurons. | Acuna-Goycolea C et al. | β | 2010 | β |
| Characterization of cannabinoid-1 receptors in the locus coeruleus: relationship with mu-opioid receptors. | Scavone JL et al. | β | 2010 | β |
| Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex. | Eggan SM et al. | β | 2010 | β |
| Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus. | Min R et al. | β | 2010 | β |
| Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. | LΓΌscher C et al. | β | 2010 | β |
| Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls. | Buczynski MW et al. | β | 2010 | β |
| Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex. | Eggan SM et al. | β | 2010 | β |
| Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | LourenΓ§o J et al. | β | 2010 | β |
| TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. | ChΓ‘vez AE et al. | β | 2010 | β |
| Differential metabotropic glutamate receptor expression and modulation in two neocortical inhibitory networks. | Sun QQ et al. | β | 2009 | β |
| Electroacupuncture modulates vlPAG release of GABA through presynaptic cannabinoid CB1 receptors. | Fu LW et al. | β | 2009 | β |
| Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. | Zhang SY et al. | β | 2009 | β |
| Endocannabinoid-mediated control of synaptic transmission. | Kano M et al. | β | 2009 | β |
| Endocannabinoid receptor pharmacology. | Yao B et al. | β | 2009 | β |
| Endocannabinoid receptors: CNS localization of the CBβ cannabinoid receptor. | Katona I | β | 2009 | β |
| Endocannabinoid signaling and long-term synaptic plasticity. | Heifets BD et al. | β | 2009 | β |
| Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex. | Berger TK et al. | β | 2009 | β |
| Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. | Hirata T et al. | β | 2009 | β |
| Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. | Won YJ et al. | β | 2009 | β |
| Origin, early commitment, migratory routes, and destination of cannabinoid type 1 receptor-containing interneurons. | Morozov YM et al. | β | 2009 | β |
| Roles of the endocannabinoid system in learning and memory. | Marsicano G et al. | β | 2009 | β |
| Self-modulation of neocortical pyramidal neurons by endocannabinoids. | Marinelli S et al. | β | 2009 | β |
| Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations. | Edwards CR et al. | β | 2009 | β |
| Synaptic transmission: excitatory autapses find a function? | Bekkers JM | β | 2009 | β |
| The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex. | Helmstaedter M et al. | β | 2009 | β |
| Cannabinoid receptors: where they are and what they do. | Mackie K | β | 2008 | β |
| Cannabinoid sensitivity and synaptic properties of 2 GABAergic networks in the neocortex. | Galarreta M et al. | β | 2008 | β |
| Cannabinoids inhibit network-driven synapse loss between hippocampal neurons in culture. | Kim HJ et al. | β | 2008 | β |
| Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. | Rimmerman N et al. | β | 2008 | β |
| Complementary modulation of somatic inhibition by opioids and cannabinoids. | Glickfeld LL et al. | β | 2008 | β |
| Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment. | Zarate J et al. | β | 2008 | β |
| Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. | Petilla Interneuron Nomenclature Group et al. | β | 2008 | β |
| Presynaptic modulation by endocannabinoids. | Lovinger DM | β | 2008 | β |
| Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. | Eggan SM et al. | β | 2008 | β |
| Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus. | Yasuda H et al. | β | 2008 | β |
| Signaling via CNS cannabinoid receptors. | Mackie K | β | 2008 | β |
| Slow GABA(A) mediated synaptic transmission in rat visual cortex. | Sceniak MP et al. | β | 2008 | β |
| The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons. | Lau T et al. | β | 2008 | β |
| The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. | Marinelli S et al. | β | 2008 | β |
| The endocannabinoid system: emotion, learning and addiction. | Moreira FA et al. | β | 2008 | β |
| The rat pineal gland comprises an endocannabinoid system. | Koch M et al. | β | 2008 | β |
| Wiring and firing neuronal networks: endocannabinoids take center stage. | Harkany T et al. | β | 2008 | β |
| Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells. | Good CH | β | 2007 | β |
| Endocannabinoids and synaptic function in the CNS. | Hashimotodani Y et al. | β | 2007 | β |
| Endocannabinoid signaling regulates spontaneous transmitter release from embryonic retinal amacrine cells. | Warrier A et al. | β | 2007 | β |
| From active ingredients to the discovery of the targets: the cannabinoid receptors. | Mackie K | β | 2007 | β |
| Functional CB1 receptors are broadly expressed in neocortical GABAergic and glutamatergic neurons. | Hill EL et al. | β | 2007 | β |
| History of cannabis and its preparations in saga, science, and sobriquet. | Russo EB | β | 2007 | β |
| In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans. | Van Laere K | β | 2007 | β |
| Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs. | Lemtiri-Chlieh F et al. | β | 2007 | β |
| Retrograde regulation of GABA transmission by the tonic release of oxytocin and endocannabinoids governs postsynaptic firing. | Oliet SH et al. | β | 2007 | β |
| Schizophrenia seen as a deficit in the modulation of cortical minicolumns by monoaminergic systems. | Casanova MF | β | 2007 | β |
| Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation. | Duguid IC et al. | β | 2007 | β |
| Spike-timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell type. | Lu JT et al. | β | 2007 | β |
| The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. | Greenhough A et al. | β | 2007 | β |
| Understanding cannabinoid psychoactivity with mouse genetic models. | Mackie K | β | 2007 | β |
| Cannabinoids, electrophysiology, and retrograde messengers: challenges for the next 5 years. | Straiker A et al. | β | 2006 | β |
| Endocannabinoid-mediated synaptic plasticity in the CNS. | Chevaleyre V et al. | β | 2006 | β |
| Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning. | Kishimoto Y et al. | β | 2006 | β |
| Local interneurons regulate synaptic strength by retrograde release of endocannabinoids. | Beierlein M et al. | β | 2006 | β |
| Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength. | Mackie K | β | 2006 | β |
| Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus. | Cannizzaro C et al. | β | 2006 | β |
| Sustained elevation of dendritic calcium evokes widespread endocannabinoid release and suppression of synapses onto cerebellar Purkinje cells. | Brenowitz SD et al. | β | 2006 | β |
| The emerging role of the endocannabinoid system in endocrine regulation and energy balance. | Pagotto U et al. | β | 2006 | β |
| Altering cannabinoid signaling during development disrupts neuronal activity. | Bernard C et al. | β | 2005 | β |
| Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope. | Alger BE | β | 2005 | β |
| Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types. | Bodor AL et al. | β | 2005 | β |
| Excitability of cortical neurons depends upon a powerful tonic conductance in inhibitory networks. | Krook-Magnuson EI et al. | β | 2005 | β |
| Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis. | KΓΆfalvi A et al. | β | 2005 | β |
| Modulation of neocortical interneurons: extrinsic influences and exercises in self-control. | Bacci A et al. | β | 2005 | β |
| Presynaptic homeostatic plasticity rescues long-term depression after chronic Delta 9-tetrahydrocannabinol exposure. | Mato S et al. | β | 2005 | β |
| Space matters: local and global dendritic Ca2+ compartmentalization in cortical interneurons. | Goldberg JH et al. | β | 2005 | β |