Statistical significance for genomewide studies.
paper
Cited
Public
Unavailable
- Authors
- Storey, John D; Tibshirani, Robert
- Year
- 2003
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 12883005
- DOI
- 10.1073/pnas.1530509100
- PMCID
- PMC170937
With the increase in genomewide experiments and the sequencing of multiple genomes, the analysis of large data sets has become commonplace in biology. It is often the case that thousands of features in a genomewide data set are tested against some null hypothesis, where a number of features are expected to be significant. Here we propose an approach to measuring statistical significance in these genomewide studies based on the concept of the false discovery rate. This approach offers a sensible balance between the number of true and false positives that is automatically calibrated and easily interpreted. In doing so, a measure of statistical significance called the q value is associated with each tested feature. The q value is similar to the well known p value, except it is a measure of significance in terms of the false discovery rate rather than the false positive rate. Our approach avoids a flood of false positive results, while offering a more liberal criterion than what has been used in genome scans for linkage.
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| Multi-Omics Analysis of Primary Prostate Cancer Datasets Reveals Novel Biomarkers. | Tuncer M et al. | β | 2025 | β |
| Multi-omics Integrative Analysis for Incomplete Data Using Weighted <i>p</i>-Value Adjustment Approaches. | Zhang W et al. | β | 2025 | β |
| Multi-omics profiles of chronic low back pain and fibromyalgia-Study protocol. | Curatolo M et al. | β | 2025 | β |
| Neurotransmitter and metabolic effects of interferon-alpha in association with decreased striatal dopamine in a non-human primate model of cytokine-Induced depression. | Bekhbat M et al. | β | 2025 | β |
| Nonparametric IPSS: fast, flexible feature selection with false discovery control. | Melikechi O et al. | β | 2025 | β |
| Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. | Logue MW et al. | β | 2025 | β |
| Organoid-based single cell sequencing revealed the lineage evolution during docetaxel treatment in gastric cancer. | Yang D et al. | β | 2025 | β |
| Pan-cancer, multi-omic correlates of survival transcending tumor lineage across 11,019 patients reveal targets and pathways. | Zhang Y et al. | β | 2025 | β |
| Patient phenotyping for molecular profiling of neck and low back pain - Study protocol. | Curatolo M et al. | β | 2025 | β |
| Peripheral Immune Cells Contribute to the Pathogenesis of Alzheimer's Disease. | Zhang H et al. | β | 2025 | β |
| Persuading voters using human-artificial intelligence dialogues. | Lin H et al. | β | 2025 | β |
| Pharmacogenomics of chemotherapy induced peripheral neuropathy using an electronic health record-derived definition: a genome-wide association study. | Jones MK et al. | β | 2025 | β |
| Plasma and ovarian metabolomic responses to chronic stress in female mice. | Lin N et al. | β | 2025 | β |
| Plasma proteomics for cognitive decline and dementia-A Southeast Asian cohort study. | Sim MA et al. | β | 2025 | β |
| Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma. | Liu X et al. | β | 2025 | β |
| Population genomics and connectivity of Vazella pourtalesii sponge grounds of the northwest Atlantic with conservation implications of deep sea vulnerable marine ecosystems. | Patova A et al. | β | 2025 | β |
| Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. | Cilleros-Portet A et al. | β | 2025 | β |
| Prediction of vaginal birth after induction of labor with maternal circulating RNA transcripts. | Ding W et al. | β | 2025 | β |
| Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. | Fuma K et al. | β | 2025 | β |
| Proteomic Profiling Uncovers Sexual Dimorphism in the Muscle Response to Wheel Running Exercise in the FLExDUX4 Murine Model of Facioscapulohumeral Muscular Dystrophy. | Nishimura Y et al. | β | 2025 | β |
| Pro-Thrombotic Changes in Response to Ambient Ozone Exposure Exacerbated by Temperatures. | Wang T et al. | β | 2025 | β |
| Protocol for discovering genetic variants associated with ATAC-seq footprint-inferred transcription factor binding. | Dudek MF et al. | β | 2025 | β |
| Query Mix-Max Method for FDR Estimation Supported by Entrapment Queries. | Madej D et al. | β | 2025 | β |
| Radiomic Features Prognosticate Treatment Response in CAR-T Cell Therapy. | Balagurunathan Y et al. | β | 2025 | β |
| Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization. | Milewski TM et al. | β | 2025 | β |
| Regulation of trophectoderm morphogenesis by small GTPase RHOA through HIPPO signaling-dependent and -independent mechanisms in mouse preimplantation development. | Marikawa Y et al. | β | 2025 | β |
| Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk. | Kramer NE et al. | β | 2025 | β |
| Response of Blood Pressure to Renal Denervation Is Not Associated With Genetic Variants. | Delles C et al. | β | 2025 | β |
| Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes. | Byun S et al. | β | 2025 | β |
| Ribitol and ribose treatments differentially affect metabolism of muscle tissue in FKRP mutant mice. | Cataldi MP et al. | β | 2025 | β |
| Risk stratification of acute exacerbations by autoantibodies in patients with idiopathic interstitial pneumonia. | Yazawa S et al. | β | 2025 | β |
| Role of telomere maintenance genes as a predictive biomarker for colorectal cancer immunotherapy response and prognosis. | Wang Z et al. | β | 2025 | β |
| scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework. | Zhou Y et al. | β | 2025 | β |
| Secure and federated quantitative trait loci mapping with privateQTL. | Choi YA et al. | β | 2025 | β |
| Selection Over Small and Large Spatial Scales in the Face of High Gene Flow. | Rumberger C et al. | β | 2025 | β |
| Sensory Perception of Fluctuating Light in Arabidopsis. | Belmonte A et al. | β | 2025 | β |
| Serum metabolites link immune-microbiota interaction in children and young adults from Russian Karelia and Finnish Karelia with contrasting lifestyle and environment. | Karisola P et al. | β | 2025 | β |
| Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes. | Xiao Y et al. | β | 2025 | β |
| Sex-specific phosphoproteome responses to calorie restriction and insulin in skeletal muscle from older rats. | Wang H et al. | β | 2025 | β |
| Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis. | Erkosar B et al. | β | 2025 | β |
| Single-Nucleus RNA Sequencing Reveals Enduring Signatures of Acute Stress and Chronic Exercise in Striatal Microglia. | Connolly MG et al. | β | 2025 | β |
| Soil and pasture health underlie improved beef nutrient density determined by untargeted metabolomics in Southern US grass finished beef systems. | Ahsin M et al. | β | 2025 | β |
| SpaNorm: spatially-aware normalization for spatial transcriptomics data. | Salim A et al. | β | 2025 | β |
| Tensor decomposition reveals trans-regulated gene modules in maize drought response. | Lu J et al. | β | 2025 | β |
| Tests for segregation distortion in higher ploidy F1 populations. | Gerard D et al. | β | 2025 | β |
| The development of ideal insertion and deletion (InDel) markers and initial indel map variation in cucumber using re-sequenced data. | Yang J et al. | β | 2025 | β |
| The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR. | Callahan A et al. | β | 2025 | β |
| The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health. | Hirohama D et al. | β | 2025 | β |
| The RNA-binding protein HuR regulates microRNA biogenesis via increased drosha expression. | Liu L et al. | β | 2025 | β |
| The Role of Gut-Brain Tryptophan Metabolism and Fatty Acid Peroxidation in the Effect of Sleep Deprivation on Anxiety and Depression in PCOS Mice. | Han T et al. | β | 2025 | β |
| The role of inflammatory cytokines and blood metabolites in osteoporosis: A Mendelian randomization study on pathways and therapeutic targets. | Liu Y et al. | β | 2025 | β |
| The Significant Effects of Threshold Selection for Advancing Nitrogen Use Efficiency in Whole Genome of Bread Wheat. | Sadeqi MB et al. | β | 2025 | β |
| Tracing the pathways: how inflammatory cytokines and blood metabolites drive intervertebral disc degeneration. | Liu Y et al. | β | 2025 | β |
| Transcriptome profiles of blastocysts originating from oocytes matured in follicular fluid from preovulatory follicles of greater or lesser maturity. | Stokes AE et al. | β | 2025 | β |
| Transcriptome reveal gene regulation mechanisms of the barnacle Chthamalus challengeri for microhabitat adaption in the intertidal zone. | Li H et al. | β | 2025 | β |
| Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer. | Xu X et al. | β | 2025 | β |
| Transcriptomic analysis of effects of developmental PCB exposure in the hypothalamus of female rats. | Streifer M et al. | β | 2025 | β |
| Transcriptomic profiling of hypothalamic development in female rats. | Hilz EN et al. | β | 2025 | β |
| Trans-eQTL hotspots shape complex traits by modulating cellular states. | Renganaath K et al. | β | 2025 | β |
| Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus. | Freimann K et al. | β | 2025 | β |
| Transgressive gene expression disrupts the molting process in hybrids of two invasive termites. | Kim KS et al. | β | 2025 | β |
| Transomic analysis reveals DNA methylation and transcription factor roles in obese liver protein expression. | Maehara H et al. | β | 2025 | β |
| Uncovering the gut microbiota's role in temporomandibular joint disorders: A bidirectional Mendelian randomization study. | Ni T et al. | β | 2025 | β |
| Unique genetic signatures in HIV-1 subtype A1 and A1D recombinant envelope glycoprotein distinguish contemporary transmitted/founder viruses from historical strains in East Africa. | Kato F et al. | β | 2025 | β |
| Unprecedented lead tolerance in an urban lizard. | Blanchette A et al. | β | 2025 | β |
| Unraveling the Metabolic Mechanisms and Novel Biomarkers of Vulvar Lichen Simplex Chronicus Using Skin Biopsy and Tape Stripping Samples. | He T et al. | β | 2025 | β |
| Updating descriptive sensory evaluation of chicken: proposing new protocols and statistical analysis. | Siebenmorgen C et al. | β | 2025 | β |
| Using Structural Equation Models to Interpret Genome-Wide Association Studies for Morphological and Productive Traits in Soybean [<i>Glycine max</i> (L.) Merr.]. | Massariol Suela M et al. | β | 2025 | β |
| Vegetarian Dietary Patterns and Diet-Related Metabolites Are Associated With Kidney Function in the Adventist Health Study-2 Cohort. | Butler FM et al. | β | 2025 | β |
| Water shortage reduces PHYTOCHROME INTERACTING FACTOR 4, 5 and 3 expression and shade avoidance in Arabidopsis. | Semmoloni M et al. | β | 2025 | β |
| 1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature. | Tonelotto V et al. | β | 2024 | β |
| A Baseline Model of PTSD From the ACES Cohort. | Millington DJ et al. | β | 2024 | β |
| A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli. | Giusti SA et al. | β | 2024 | β |
| A Case-Control Study Supports Genetic Contribution of the <i>PON</i> Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease. | Van Dijck E et al. | β | 2024 | β |
| Accounting for isoform expression increases power to identify genetic regulation of gene expression. | LaPierre N et al. | β | 2024 | β |
| A comparative analysis of mutual information methods for pairwise relationship detection in metagenomic data. | Francis D et al. | β | 2024 | β |
| A Comprehensive and Broad Approach to Resting-State Functional Connectivity in Adult Patients with Mild Traumatic Brain Injury. | Arabshahi S et al. | β | 2024 | β |
| Acquisition and Analysis of DIA-Based Proteomic Data: A Comprehensive Survey inΒ 2023. | Lou R et al. | β | 2024 | β |
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| A female-biased gene expression signature of dominance in cooperatively breeding meerkats. | Campbell CR et al. | β | 2024 | β |
| A global transcriptional atlas of the effect of acute sleep deprivation in the mouse frontal cortex. | Ford K et al. | β | 2024 | β |
| Air pollution and human health: a phenome-wide association study. | Hegelund ER et al. | β | 2024 | β |
| A landscape of gene expression regulation for synovium in arthritis. | Jiang F et al. | β | 2024 | β |
| Altered microRNA composition in the uterine lumen fluid in cattle (Bos taurus) pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo. | Biase FH et al. | β | 2024 | β |
| Alternative splicing induces sample-level variation in gene-gene correlations. | Lu Y et al. | β | 2024 | β |
| A metagenomics study reveals the gut microbiome as a sex-specific modulator of healthy aging in Hainan centenarians. | Luan Z et al. | β | 2024 | β |
| A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma. | Hemnes A et al. | β | 2024 | β |
| A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping. | Dong P et al. | β | 2024 | β |
| A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma. | Ryl T et al. | β | 2024 | β |
| Analysis of behavioral flow resolves latent phenotypes. | von Ziegler LM et al. | β | 2024 | β |
| Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry. | Benjamin KJM et al. | β | 2024 | β |
| Analyzing the Impact of the Highest Expressed Epstein-Barr Virus-Encoded microRNAs on the Host Cell Transcriptome. | Hohmann T et al. | β | 2024 | β |
| An essential gene signature of breast cancer metastasis reveals targetable pathways. | Zhang Y et al. | β | 2024 | β |
| A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver. | Perry AS et al. | β | 2024 | β |
| Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in autoimmune rheumatic diseases: a brief research report from a Mendelian randomization study. | Xu X et al. | β | 2024 | β |
| Association between 35 blood and urine biomarkers and oral leukoplakia: a two-sample Mendelian randomization study. | Ouyang YL et al. | β | 2024 | β |
| Association between gut microbiota and autoimmune cholestatic liver disease, a Mendelian randomization study. | Cui Y et al. | β | 2024 | β |
| Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study. | Ye C et al. | β | 2024 | β |
| Association between gut microbiota and diabetic microvascular complications: a two-sample Mendelian randomization study. | Zhou P et al. | β | 2024 | β |
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| Association between gut microbiota and pan-dermatological diseases: a bidirectional Mendelian randomization research. | Wang Y et al. | β | 2024 | β |
| Association Between Periodontitis and Preeclampsia: A Bidirectional Mendelian Randomisation Analysis. | Cao J et al. | β | 2024 | β |
| Association between quantity and quality of carbohydrate intake and glaucoma: a cross-sectional study from the NHANES database. | Li F et al. | β | 2024 | β |
| Association mapping unravels the genetic basis for drought related traits in different developmental stages of barley. | Slawin C et al. | β | 2024 | β |
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| Associations between type 1 diabetes and autoimmune skin diseases: Mendelian randomization analysis. | Liu J et al. | β | 2024 | β |
| Asymptotic uncertainty of false discovery proportion. | Mei M et al. | β | 2024 | β |
| Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression. | Deng L et al. | β | 2024 | β |
| Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities. | Zhou J et al. | β | 2024 | β |
| A two-sample bidirectional Mendelian randomization analysis investigates associations between gut microbiota and type 2 diabetes mellitus. | Song S et al. | β | 2024 | β |
| A two sample mendelian randomization analysis investigates causal effects between gut microbiome and immune related Vasculitis. | Chen S et al. | β | 2024 | β |
| Automated preparation of plasma lipids, metabolites, and proteins for LC/MS-based analysis of a high-fat diet in mice. | Vu N et al. | β | 2024 | β |
| Beta<sub>2</sub>-Adrenergic Stimulation Induces Resistance Training-Like Adaptations in Human Skeletal Muscle: Potential Role of KLHL41. | Jessen S et al. | β | 2024 | β |
| Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy. | Song S et al. | β | 2024 | β |
| Brain physiology during photoperiod-related caste determination in the primitively eusocial wasp Polistes jokahamae. | Sasaki K et al. | β | 2024 | β |
| Causal associations between gut microbiota, circulating inflammatory proteins, and epilepsy: a multivariable Mendelian randomization study. | Yang H et al. | β | 2024 | β |
| Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study. | Yan J et al. | β | 2024 | β |
| Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study. | Xin Q et al. | β | 2024 | β |
| Causal Effects of Oxidative Stress on Diabetes Mellitus and Microvascular Complications: Insights Integrating Genome-Wide Mendelian Randomization, DNA Methylation, and Proteome. | Liu K et al. | β | 2024 | β |
| Causal relationship between circulating insulin-like growth factor-1 and Parkinson's disease: a two-sample Mendelian randomization study. | Xu J et al. | β | 2024 | β |
| Causal relationship between gut microbiota and chronic renal failure: a two-sample Mendelian randomization study. | Liu X et al. | β | 2024 | β |
| Causal relationship between gut microbiota and glioblastoma: a two-sample Mendelian randomization study. | Ju C et al. | β | 2024 | β |
| Causal relationship between mitochondrial-associated proteins and cerebral aneurysms: a Mendelian randomization study. | Wang S et al. | β | 2024 | β |
| Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study. | Ma R et al. | β | 2024 | β |
| Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders. | Boltz T et al. | β | 2024 | β |
| Chronic arsenic exposure induces malignant transformation of human HaCaT cells through both deterministic and stochastic changes in transcriptome expression. | Banerjee M et al. | β | 2024 | β |
| Chronic exposure to environmental concentrations of benzo[a]pyrene causes multifaceted toxic effects of developmental compromise, redox imbalance, and modulated transcriptional profiles in the early life stages of marine medaka (Oryzias melastigma). | Zeb R et al. | β | 2024 | β |
| Circadian transcriptome oscillations in human adipose tissue depend on napping status and link to metabolic and inflammatory pathways. | RodrΓguez-MartΓn M et al. | β | 2024 | β |
| Cis-eQTLs in seven duck tissues identify novel candidate genes for growth and carcass traits. | Cai W et al. | β | 2024 | β |
| Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children. | van de Wouw M et al. | β | 2024 | β |
| Comparative analysis of proteomic adaptations in Enterococcus faecalis and Enterococcus faecium after long term bile acid exposure. | Dreyer A et al. | β | 2024 | β |
| Coping with alpine habitats: genomic insights into the adaptation strategies of <i>Triplostegia glandulifera</i> (Caprifoliaceae). | Zhang J et al. | β | 2024 | β |
| Correlation between hearing loss and mild cognitive impairment in the elderly population: Mendelian randomization and cross-sectional study. | Xu T et al. | β | 2024 | β |
| Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies. | Chen Y et al. | β | 2024 | β |
| Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. | Wen C et al. | β | 2024 | β |
| DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH. | Geiduschek EK et al. | β | 2024 | β |
| Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation. | Khan B et al. | β | 2024 | β |
| Decoding epigenetic markers: implications of traits and genes through DNA methylation in resilience and susceptibility to mastitis in dairy cows. | Bouzeraa L et al. | β | 2024 | β |
| Deconstructing depression by machine learning: the POKAL-PSY study. | Eder J et al. | β | 2024 | β |
| Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections. | Schupp PG et al. | β | 2024 | β |
| Deep learning-based pathway-centric approach to characterize recurrent hepatocellular carcinoma after liver transplantation. | To J et al. | β | 2024 | β |
| Degradation of FATTY ACID EXPORT PROTEIN1 by RHOMBOID-LIKE PROTEASE11 contributes to cold tolerance in Arabidopsis. | John A et al. | β | 2024 | β |
| Detecting differential transcript usage in complex diseases with SPIT. | Erdogdu B et al. | β | 2024 | β |
| Differences in Gut Microbes Across Age and Sex Linked to Metabolism and Microbial Stability in a Hibernating Mammal. | Pfau M et al. | β | 2024 | β |
| Differential network connectivity analysis for microbiome data adjusted for clinical covariates using jackknife pseudo-values. | Ahn S et al. | β | 2024 | β |
| DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes. | Frommelt F et al. | β | 2024 | β |
| Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. | Nanda AS et al. | β | 2024 | β |
| DNA methylation-environment interactions in the human genome. | Johnston RA et al. | β | 2024 | β |
| Dried fruit intake can lower the risk of ulcerative colitis: evidence from a Mendelian randomization study. | Bu Z et al. | β | 2024 | β |
| Effect of particulate matter on cognitive function among middle-aged and older adults in China: An instrumental variable approach. | Zhao Q et al. | β | 2024 | β |
| Effect of the gut microbiome in glaucoma risk from the causal perspective. | Wu Y et al. | β | 2024 | β |
| Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size. | Duncan MC et al. | β | 2024 | β |
| Effects of the nematode <i>Litylenchus crenatae</i> subsp. <i>mccannii</i> and beech leaf disease on leaf fungal and bacterial communities on <i>Fagus grandifolia</i> (American beech). | Burke DJ et al. | β | 2024 | β |
| Effects of Zinc Supplementation on Metabolomic Profiles in Tanzanian Infants: A Randomized Trial. | Liu E et al. | β | 2024 | β |
| Electronic Cigarette Vape Exposure Exacerbates Post-Ischemic Outcomes in Female but Not in Male Rats. | Pradhyumnan H et al. | β | 2024 | β |
| Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancer. | Sun C et al. | β | 2024 | β |
| Environmental Factor Index (EFI): A Novel Approach to Measure the Strength of Environmental Influence on DNA Methylation in Identical Twins. | Takenaka Y et al. | β | 2024 | β |
| Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. | Aracena KA et al. | β | 2024 | β |
| Exact Integral Formulas for False Discovery Rate and the Variance of False Discovery Proportion. | Sadygov RG et al. | β | 2024 | β |
| Exact p-value calculation for XCorr scoring of high-resolution MS/MS data. | Bhimani K et al. | β | 2024 | β |
| Exploration of the potential causative genes for inflammatory bowel disease: Transcriptome-wide association analysis, Mendelian randomization analysis and Bayesian colocalisation. | Luo Q et al. | β | 2024 | β |
| Exploring risk factors for autoimmune diseases complicated by non-hodgkin lymphoma through regulatory T cell immune-related traits: a Mendelian randomization study. | Liu Q et al. | β | 2024 | β |
| Exploring the causal association between genetically determined circulating metabolome and hemorrhagic stroke. | Wang Y et al. | β | 2024 | β |
| Exploring the causal relationship between gut microbiota and frailty: a two-sample mendelian randomization analysis. | Bo F et al. | β | 2024 | β |
| Factors affecting protein recovery during Hsp40 affinity profiling. | Montoya MR et al. | β | 2024 | β |
| Family Planning and Children's Human Capital: Experimental Evidence From Urban Malawi. | Maggio D et al. | β | 2024 | β |
| Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci. | Goode EC et al. | β | 2024 | β |
| Fine mapping-based multi-omics analysis interprets the gut-lung axis function of SGLT2 inhibitors. | Yuan F et al. | β | 2024 | β |
| Frequent nonhomologous replacement of replicative helicase loaders by viruses in <i>Vibrionaceae</i>. | Tominaga K et al. | β | 2024 | β |
| Genetically correlated leaf tensile and morphological traits are driven by growing season length in a widespread perennial grass. | Durant PC et al. | β | 2024 | β |
| Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| Genetic architecture of ecological divergence between Oryza rufipogon and Oryza nivara. | Meng QL et al. | β | 2024 | β |
| Genetic association between gut microbiota and the risk of Guillain-BarrΓ© syndrome. | Cao F et al. | β | 2024 | β |
| Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. | Komine O et al. | β | 2024 | β |
| Genetic effects on the skin methylome in healthy older twins. | Shore CJ et al. | β | 2024 | β |
| Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study. | Petrykey K et al. | β | 2024 | β |
| Genetic Insights into the Association and Causality Between Blood Metabolites and Alzheimer's Disease. | Zhai M et al. | β | 2024 | β |
| Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis. | AygΓΌn N et al. | β | 2024 | β |
| Genome-Wide Association Studies on Resistance to Pea Weevil: Identification of Novel Sources of Resistance and Associated Markers. | Osuna-Caballero S et al. | β | 2024 | β |
| Genome-wide association study uncovers pea candidate genes and metabolic pathways involved in rust resistance. | Osuna-Caballero S et al. | β | 2024 | β |
| Genome-wide expression analysis of vegetative organs during developmental and herbicide-induced whole plant senescence in Arabidopsis thaliana. | Chen PY et al. | β | 2024 | β |
| Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. | Hughes O et al. | β | 2024 | β |
| Genomic signals of local adaptation across climatically heterogenous habitats in an invasive tropical fruit fly (Bactrocera tryoni). | Parvizi E et al. | β | 2024 | β |
| Germline structural variation globally impacts the cancer transcriptome including disease-relevant genes. | Chen F et al. | β | 2024 | β |
| Global impact of unproductive splicing on human gene expression. | Fair B et al. | β | 2024 | β |
| Gut microbiota linked to hydrocephalus through inflammatory factors: a Mendelian randomization study. | Shen Y et al. | β | 2024 | β |
| Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization. | Lu Y et al. | β | 2024 | β |
| Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors. | Marcos-Delgado A et al. | β | 2024 | β |
| Hidradenitis suppurativa and cardiovascular diseases: A bidirectional Mendelian randomization study. | Zhou P et al. | β | 2024 | β |
| Higher expression of mir-31-5p is associated with reduced risk of head and neck keloid recurrence following surgical resection. | Levin AM et al. | β | 2024 | β |
| Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro. | GbelcovΓ‘ H et al. | β | 2024 | β |
| HiPerMAb: a tool for judging the potential of small sample size biomarker pilot studies. | Al-Mekhlafi A et al. | β | 2024 | β |
| Human lens epithelial cells induce the inflammatory response when placed into the lens capsular bag model of posterior capsular opacification. | Novo SG et al. | β | 2024 | β |
| Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism. | Hass R et al. | β | 2024 | β |
| Identification and validation of miR-29b-3p and LIN7A as important diagnostic markers for bone non-union by WGCNA. | Jian G et al. | β | 2024 | β |
| Identification of antibody targets associated with lower HIV viral load and viremic control. | Grant-McAuley W et al. | β | 2024 | β |
| Identification of Signatures of Positive Selection That Have Shaped the Genomic Landscape of South African Pig Populations. | Hlongwane NL et al. | β | 2024 | β |
| Identifying the role of MTHFD1L in prostate cancer progression from genetic analysis and experimental validation. | Tsai YC et al. | β | 2024 | β |
| Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness. | Chung KP et al. | β | 2024 | β |
| Impact of low-level exposure to antibiotics on bile acid homeostasis in adults: Implication for human safety thresholds. | Wang Y et al. | β | 2024 | β |
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| Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation. | Ashokkumar M et al. | β | 2024 | β |
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| Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome. | Jacobs JP et al. | β | 2022 | β |
| DeCAF: a novel method to identify cell-type specific regulatory variants and their role in cancer risk. | Kalita CA et al. | β | 2022 | β |
| Depletion of <i>Mdig</i> Changes Proteomic Profiling in Triple Negative Breast Cancer Cells. | Thakur C et al. | β | 2022 | β |
| Detection of Embryonic Trisomy 21 in the First Trimester Using Maternal Plasma Cell-Free RNA. | Weiner CP et al. | β | 2022 | β |
| Detection of Genomic Imprinting for Carcass Traits in Cattle Using Imputed High-Density Genotype Data. | Kenny D et al. | β | 2022 | β |
| Dissecting the cotranscriptome landscape of plants and their microbiota. | Nobori T et al. | β | 2022 | β |
| Dissecting the genetic control of natural variation in sorghum photosynthetic response to drought stress. | Ortiz D et al. | β | 2022 | β |
| Distinct Cellular Tools of Mild Hyperthermia-Induced Acquired Stress Tolerance in Chinese Hamster Ovary Cells. | Tiszlavicz Γ et al. | β | 2022 | β |
| Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels. | Lea AJ et al. | β | 2022 | β |
| Dynamic human liver proteome atlas reveals functional insights into disease pathways. | Niu L et al. | β | 2022 | β |
| Dynamic Transcriptomic Profiling During Liver Development in <i>Schizothorax Prenanti</i>. | Ni J et al. | β | 2022 | β |
| Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection. | Fallet M et al. | β | 2022 | β |
| Effect of Killed PRRSV Vaccine on Gut Microbiota Diversity in Pigs. | Yuan F et al. | β | 2022 | β |
| Effects of air exposure stress on crustaceans: Histopathological changes, antioxidant and immunity of the red swamp crayfish Procambarus clarkii. | Zhang YM et al. | β | 2022 | β |
| Effects of uteroplacental insufficiency on growth-restricted rats with altered lung development: A metabolomic analysis. | Yuliana ME et al. | β | 2022 | β |
| Efficient permutation-based genome-wide association studies for normal and skewed phenotypic distributions. | John M et al. | β | 2022 | β |
| Efficient testing and effect size estimation for set-based genetic association inference via semiparametric multilevel mixture modeling. | Sugasawa S et al. | β | 2022 | β |
| Ensemble classification based signature discovery for cancer diagnosis in RNA expression profiles across different platforms. | Zhao X et al. | β | 2022 | β |
| Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences. | Kaliman P et al. | β | 2022 | β |
| Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. | Liu H et al. | β | 2022 | β |
| Evolutionary Divergence of <i>Marinobacter</i> Strains in Cryopeg Brines as Revealed by Pangenomics. | Cooper ZS et al. | β | 2022 | β |
| ExPheWas: a platform for cis-Mendelian randomization and gene-based association scans. | Legault MA et al. | β | 2022 | β |
| Facilitating early parent-infant emotional connection improves cortical networks in preterm infants. | YrjΓΆlΓ€ P et al. | β | 2022 | β |
| Facing the Green Threat: A Water Flea's Defenses against a Carnivorous Plant. | Kruppert S et al. | β | 2022 | β |
| fdrci: FDR confidence interval selection and adjustment for large-scale hypothesis testing. | Millstein J et al. | β | 2022 | β |
| Functional signatures <i>of ex-vivo</i> dental caries onset. | Moussa DG et al. | β | 2022 | β |
| Gene Expression Linked to Reepithelialization of Human Skin Wounds. | Γ gren MS et al. | β | 2022 | β |
| Genetic Analysis Implicates Dysregulation of <i>SHANK2</i> in Renal Cell Carcinoma Progression. | Chang CF et al. | β | 2022 | β |
| Genetic architecture and QTL selection response for Kernza perennial grain domestication traits. | Crain J et al. | β | 2022 | β |
| Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population. | Sonehara K et al. | β | 2022 | β |
| Genetic Dissection of Phosphorus Use Efficiency and Genotype-by-Environment Interaction in Maize. | Li D et al. | β | 2022 | β |
| Genetic dissection of the RNA polymerase II transcription cycle. | Chou SP et al. | β | 2022 | β |
| Genetics as a key to improving crop photosynthesis. | Theeuwen TPJM et al. | β | 2022 | β |
| Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet. | Ramos-Levi A et al. | β | 2022 | β |
| Genome-wide association study for resistance in bread wheat (Triticum aestivum L.) to stripe rust (Puccinia striiformis f. sp. tritici) races in Argentina. | Franco MF et al. | β | 2022 | β |
| Genomic signatures of recent convergent transitions to social life in spiders. | Tong C et al. | β | 2022 | β |
| G Protein-Coupled Receptor 15 Expression Is Associated with Myocardial Infarction. | Haase T et al. | β | 2022 | β |
| Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation. | Espinoza MF et al. | β | 2022 | β |
| Human follicular mites: Ectoparasites becoming symbionts. | Smith G et al. | β | 2022 | β |
| Identification and validation of TCONS_00093333 for regulating fertility conversion of thermo-sensitive cytoplasmic male-sterility wheat with Aegilops kotschyi cytoplasm. | Ye J et al. | β | 2022 | β |
| Identification of a Novel Long Non-coding RNA, <i>lnc-ATMIN-4:2</i>, and its Clinicopathological and Prognostic Significance in Advanced Gastric Cancer. | Kim E et al. | β | 2022 | β |
| Identification of cell-type-specific spatially variable genes accounting for excess zeros. | Yu J et al. | β | 2022 | β |
| Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in mice. | Wang Y et al. | β | 2022 | β |
| Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer. | Fasching PA et al. | β | 2022 | β |
| Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis. | Singh A et al. | β | 2022 | β |
| Immune disease risk variants regulate gene expression dynamics during CD4<sup>+</sup> T cell activation. | Soskic B et al. | β | 2022 | β |
| Impact of sublethal chlorantraniliprole on epidermis of Bombyx mori during prepupal-pupal transition. | Liu X et al. | β | 2022 | β |
| Improvements Achieved by Multiple Imputation for Single-Cell RNA-Seq Data in Clustering Analysis and Differential Expression Analysis. | Zhu M et al. | β | 2022 | β |
| ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data. | Aftab W et al. | β | 2022 | β |
| Integrated bioinformatics analysis and screening of hub genes in polycystic ovary syndrome. | Qiao G et al. | β | 2022 | β |
| Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRΞ± deficiency. | Dufour CR et al. | β | 2022 | β |
| Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer. | Blaschke CRK et al. | β | 2022 | β |
| Integrating variant functional annotation scores have varied abilities to improve power of genome-wide association studies. | Gao J et al. | β | 2022 | β |
| Integrative analysis of drug response and clinical outcome in acute myeloid leukemia. | Bottomly D et al. | β | 2022 | β |
| Integrative multi-omics database (iMOMdb) of Asian pregnant women. | Pan H et al. | β | 2022 | β |
| Ketogenic diet uncovers differential metabolic plasticity of brain cells. | DΓΌking T et al. | β | 2022 | β |
| Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia. | Alver M et al. | β | 2022 | β |
| Low Temperature Inhibits the Defoliation Efficiency of Thidiazuron in Cotton by Regulating Plant Hormone Synthesis and the Signaling Pathway. | Shu H et al. | β | 2022 | β |
| Mediterranean Diet Reduces Social Isolation and Anxiety in Adult Female Nonhuman Primates. | Johnson CSC et al. | β | 2022 | β |
| Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes. | Yang C et al. | β | 2022 | β |
| Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults. | Chou CH et al. | β | 2022 | β |
| Metabolomics-guided discovery of cytochrome P450s involved in pseudotropine-dependent biosynthesis of modified tropane alkaloids. | Sadre R et al. | β | 2022 | β |
| Metabolomics in pulmonary medicine: extracting the most from your data. | Reinke SN et al. | β | 2022 | β |
| Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition. | Crist M et al. | β | 2022 | β |
| MicroRNA expression within neuronal-derived small extracellular vesicles in frontotemporal degeneration. | Pounders J et al. | β | 2022 | β |
| miRNA-mRNA-protein dysregulated network in COPD in women. | Li CX et al. | β | 2022 | β |
| Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2. | Reynisdottir T et al. | β | 2022 | β |
| Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. | Downey J et al. | β | 2022 | β |
| MtEFD and MtEFD2: Two transcription factors with distinct neofunctionalization in symbiotic nodule development. | Jardinaud MF et al. | β | 2022 | β |
| Multi-Cell-Type Openness-Weighted Association Studies for Trait-Associated Genomic Segments Prioritization. | Song S et al. | β | 2022 | β |
| Multiple lineages of monkeypox virus detected in the United States, 2021-2022. | Gigante CM et al. | β | 2022 | β |
| Mutational signatures are markers of drug sensitivity of cancer cells. | LevatiΔ J et al. | β | 2022 | β |
| Orang Asli Health and Lifeways Project (OA HeLP): a cross-sectional cohort study protocol. | Wallace IJ et al. | β | 2022 | β |
| Phase-Based Cortical Synchrony Is Affected by Prematurity. | YrjΓΆlΓ€ P et al. | β | 2022 | β |
| Phenotypic and transcriptional response of Daphnia pulicaria to the combined effects of temperature and predation. | Oliver A et al. | β | 2022 | β |
| Pneumococcal within-host diversity during colonization, transmission and treatment. | Tonkin-Hill G et al. | β | 2022 | β |
| Population-level variation in enhancer expression identifies disease mechanisms in the human brain. | Dong P et al. | β | 2022 | β |
| PqsE Expands and Differentially Modulates the RhlR Quorum Sensing Regulon in Pseudomonas aeruginosa. | Letizia M et al. | β | 2022 | β |
| Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients. | Hatfield KJ et al. | β | 2022 | β |
| Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. | Zhang Y et al. | β | 2022 | β |
| Regulation of HLA class I expression by non-coding gene variations. | Bettens F et al. | β | 2022 | β |
| Remodeling of Liver and Plasma Lipidomes in Mice Lacking Cyclophilin D. | Koszegi B et al. | β | 2022 | β |
| Resequencing the Yaroslavl cattle genomes reveals signatures of selection and a rare haplotype on BTA28 likely to be related to breed phenotypes. | Ruvinskiy D et al. | β | 2022 | β |
| Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer. | Tucker JD et al. | β | 2022 | β |
| RNA editing underlies genetic risk of common inflammatory diseases. | Li Q et al. | β | 2022 | β |
| RNA-seq analysis reveals genes related to photosynthetic carbon partitioning and lipid production in <i>Phaeodactylum tricornutum</i> under alkaline conditions. | Liu J et al. | β | 2022 | β |
| RUV-III-NB: normalization of single cell RNA-seq data. | Salim A et al. | β | 2022 | β |
| Salivary microRNA and Metabolic Profiles in a Mouse Model of Subchronic and Mild Social Defeat Stress. | Yoshida Y et al. | β | 2022 | β |
| Searching for signatures of sexually antagonistic selection on stickleback sex chromosomes. | Dagilis AJ et al. | β | 2022 | β |
| Selection against admixture and gene regulatory divergence in a long-term primate field study. | Vilgalys TP et al. | β | 2022 | β |
| Selenium Nanoparticles (SeNPs) Immunomodulation Is More Than Redox Improvement: Serum Proteomics and Transcriptomic Analyses. | Xia IF et al. | β | 2022 | β |
| Serine and arginine rich splicing factor 1 deficiency alters pathways involved in IL-17A expression and is implicated in human psoriasis. | Su S et al. | β | 2022 | β |
| Significant hot hand effect in the game of cricket. | Ram SK et al. | β | 2022 | β |
| Statistical analysis of spatially resolved transcriptomic data by incorporating multiomics auxiliary information. | Li Y et al. | β | 2022 | β |
| Stromal changes in the aged lung induce an emergence from melanoma dormancy. | Fane ME et al. | β | 2022 | β |
| Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation. | Chen PB et al. | β | 2022 | β |
| Targeted Resequencing of Otosclerosis Patients from Different Populations Replicates Results from a Previous Genome-Wide Association Study. | Tavernier LJM et al. | β | 2022 | β |
| Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program. | Foster DB et al. | β | 2022 | β |
| Temporally Regulated Plant-Nematode Gene Networks Implicate Metabolic Pathways. | Mishra S et al. | β | 2022 | β |
| The genetic basis of transpiration sensitivity to vapor pressure deficit in wheat. | Tamang BG et al. | β | 2022 | β |
| The origin of bladder cancer from mucosal field effects. | Bondaruk J et al. | β | 2022 | β |
| The RNA editing landscape in acute myeloid leukemia reveals associations with disease mutations and clinical outcome. | Meduri E et al. | β | 2022 | β |
| The Two Domains of the Avian Double-Ξ²-Defensin AvBD11 Have Different Ancestors, Common with Potential Monodomain Crocodile and Turtle Defensins. | Guyot N et al. | β | 2022 | β |
| The zinc-finger transcription factor LSL-1 is a major regulator of the germline transcriptional program in Caenorhabditis elegans. | Rodriguez-Crespo D et al. | β | 2022 | β |
| Tight gene co-expression in BCB positive cattle oocytes and their surrounding cumulus cells. | Walker BN et al. | β | 2022 | β |
| Time and age dependent regulation of neuroinflammation in a rat model of mesial temporal lobe epilepsy: Correlation with human data. | Erisken S et al. | β | 2022 | β |
| TNFRSF13B is a potential contributor to prostate cancer. | Li CY et al. | β | 2022 | β |
| Transcriptome analysis revealed potential genes involved in thermogenesis in muscle tissue in cold-exposed lambs. | Ji K et al. | β | 2022 | β |
| Transcriptome sequencing and DEG analysis in different developmental stages of floral buds induced by potassium chlorate in <i>Dimocarpus longan</i>. | Huang S et al. | β | 2022 | β |
| Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation. | Lal JC et al. | β | 2022 | β |
| Transection injury differentially alters the proteome of the human sural nerve. | Chau MJ et al. | β | 2022 | β |
| Trans-genetic effects of circular RNA expression quantitative trait loci and potential causal mechanisms in autism. | Mai TL et al. | β | 2022 | β |
| Understanding Uncertainty Maps in Vision with Statistical Testing. | Nazarovs J et al. | β | 2022 | β |
| VMP1 Regulated by chi-miR-124a Effects Goat Myoblast Proliferation, Autophagy, and Apoptosis through the PI3K/ULK1/mTOR Signaling Pathway. | Liu Y et al. | β | 2022 | β |
| Whole-body transcriptome analysis provides insights into the cascade of sequential expression events involved in growth, immunity, and metabolism during the molting cycle in Scylla paramamosain. | Liu L et al. | β | 2022 | β |