Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.
- Authors
- Ding, Jian-hua; Li, Su-ping; Cao, Hai-xia; Wu, Jian-zhong; Gao, Chang-ming; Liu, Yan-ting; Zhou, Jian-nong; Chang, Jun; Yao, Geng-hong
- Year
- 2010
- Journal
- Journal of human genetics
- PMID
- 20010786
- DOI
- 10.1038/jhg.2009.129
To investigate the relationship among alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) genetic polymorphisms, alcohol consumption and the susceptibility to esophageal cancer in a Chinese population, we conducted a case-control study with 221 cases and 191 population-based controls in the Taixing city of Jiangsu Province of China. ADH2 and ALDH2 genotypes were examined using PCR and denaturing high-performance liquid chromatography. Alcohol drinkers with the ALDH2 A allele showed a significantly increased risk of esophageal cancer compared with drinkers with the ALDH2 G/G genotype (odds ratio (OR)=3.08, 95% confidence interval (CI): 1.65-5.78) or nondrinkers with any genotype (OR=3.05, 95% CI: 1.49-6.25). Drinkers with the ALDH2 A allele and a cumulative amount of alcohol consumption > or =2.5 (kg * years) were at a significantly higher risk of developing esophageal cancer (OR=11.93, 95% CI: 3.17-44.90) compared with individuals with ALDH2 G/G genotypes and a cumulative amount of alcohol consumption <2.5 (kg * years). A dose-dependent positive result was found between cumulative amount of alcohol consumption and risk of esophageal cancer in individuals carrying the ALDH2 A allele (P=0.023) and the homozygous ALDH2 G allele (P=0.047). Compared with individuals carrying both ALDH2 G/G and ADH2 A/A alleles and with a cumulative amount of alcohol consumption <2.5 (kg * years), drinkers carrying both ALDH2 A and ADH2 G alleles and with a cumulative amount of alcohol consumption > or =2.5 (kg * years) showed a significantly elevated risk of esophageal cancer (OR=53.15, 95% CI: 4.24-666.84). This result suggests that to help lower their risk for esophageal cancer, persons carrying the ALDH2 A allele should be encouraged to reduce their consumption of alcoholic beverages.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Challenges and promises of nutritional epidemiology to investigate cancer etiology. | Ferrari P et al. | — | 2026 | → |
| Recent advances in alcohol metabolism: from the gut to the brain. | Goldman MR et al. | — | 2025 | → |
| Alcohol accumulation promotes esophagitis via pyroptosis activation. | Wang F et al. | — | 2018 | → |
| Alcohol metabolism and oesophageal cancer: a systematic review of the evidence. | Matejcic M et al. | — | 2017 | → |
| Factors associated with the high prevalence of oesophageal cancer in Western Kenya: a review. | Kigen G et al. | — | 2017 | → |
| Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. | Mao N et al. | — | 2016 | → |
| Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. | Eriksson CJ | — | 2015 | → |
| Gene-environment interactions on the risk of esophageal cancer among Asian populations with the G48A polymorphism in the alcohol dehydrogenase-2 gene: a meta-analysis. | Zhang L et al. | — | 2014 | → |
| Detection of synchronous cancers by fluorodeoxyglucose positron emission tomography/computed tomography during primary staging workup for esophageal squamous cell carcinoma in Taiwan. | Chen SH et al. | — | 2013 | → |
| ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. | Bierut LJ et al. | — | 2012 | → |
| Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men. | Yokoyama A et al. | — | 2012 | → |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | — | 2012 | → |
| Identifying genetic variation for alcohol dependence. | Agrawal A et al. | — | 2012 | → |
| Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa. | Bye H et al. | — | 2011 | → |
| Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians. | Yokoyama A et al. | — | 2010 | → |