Endocannabinoid signaling in the brain.
- Authors
- Wilson, Rachel I; Nicoll, Roger A
- Year
- 2002
- Journal
- Science (New York, N.Y.)
- PMID
- 11976437
- DOI
- 10.1126/science.1063545
The primary psychoactive ingredient in cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands. In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on presynaptic axons and suppressing neurotransmitter release. Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism.
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| Therapeutic Cannabis and Endocannabinoid Signaling System Modulator Use in Otolaryngology Patients. | Bryant LM et al. | β | 2018 | β |
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| 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | Almeida-Santos AF et al. | β | 2017 | β |
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| Chronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult mice. | Tomas-Roig J et al. | β | 2017 | β |
| Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain. | Li MH et al. | β | 2017 | β |
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| Pharmacology of cannabinoids in the treatment of epilepsy. | Gaston TE et al. | β | 2017 | β |
| Precondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male mice. | Manteghi F et al. | β | 2017 | β |
| Quantitative profiling of endocannabinoids and related <i>N</i>-acylethanolamines in human CSF using nano LC-MS/MS. | Kantae V et al. | β | 2017 | β |
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| The interactive role of CB1 receptors and L-type calcium channels in hippocampal long-term potentiation in rats. | Komaki H et al. | β | 2017 | β |
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| Whole-body biodistribution of the cannabinoid type 1 receptor ligand [<sup>18</sup>F]MK-9470 in the rat. | Buchholz HG et al. | β | 2017 | β |
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| Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation. | Abouchedid R et al. | β | 2016 | β |
| Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans. | Kullmann S et al. | β | 2016 | β |
| Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent. | Caballero-FlorΓ‘n RN et al. | β | 2016 | β |
| Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus. | Stempel AV et al. | β | 2016 | β |
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| Different Paths to Core Pathology: The Equifinal Model of the Schizophrenia Syndrome. | Green IW et al. | β | 2016 | β |
| Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors. | Olmo IG et al. | β | 2016 | β |
| Dorsolateral periaqueductal gray matter CB1 and TRPV1 receptors exert opposite modulation on expression of contextual fear conditioning. | Uliana DL et al. | β | 2016 | β |
| Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(Ξ±) and (m)VD-hemopressin(Ξ±) on memory in novel object and object location recognition tasks in normal young and AΞ²1-42-treated mice. | Zhang RS et al. | β | 2016 | β |
| Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine. | Peterson BM et al. | β | 2016 | β |
| FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. | Spagnolo PA et al. | β | 2016 | β |
| High-resolution crystal structure of the human CB1 cannabinoid receptor. | Shao Z et al. | β | 2016 | β |
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| Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats. | Calik MW et al. | β | 2016 | β |
| Intra-VTA anandamide infusion produces dose-based biphasic effects on male rat sexual behavior expression. | Canseco-Alba A et al. | β | 2016 | β |
| Involvement of the infralimbic cortex and CA1 hippocampal area in reconsolidation of a contextual fear memory through CB1 receptors: Effects of CP55,940. | Santana F et al. | β | 2016 | β |
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| Marijuana Compounds: A Nonconventional Approach to Parkinson's Disease Therapy. | Babayeva M et al. | β | 2016 | β |
| Neural endocannabinoid CB1 receptor expression, social status, and behavior in male European starlings. | DeVries MS et al. | β | 2016 | β |
| Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons. | Albayram Γ et al. | β | 2016 | β |
| Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1. | Schmitz SK et al. | β | 2016 | β |
| Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits. | Vogel E et al. | β | 2016 | β |
| Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents. | Ramesh R et al. | β | 2016 | β |
| Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. | Hanlon EC et al. | β | 2016 | β |
| Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome. | Yang T et al. | β | 2016 | β |
| The effects of adolescent cannabinoid exposure on seizure susceptibility and lethality in adult male rats. | Spring MG et al. | β | 2016 | β |
| The endocannabinoid system and neuropathic pain. | Maldonado R et al. | β | 2016 | β |
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| Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. | Deiana V et al. | β | 2016 | β |
| What Should We Tell Our Patients About Marijuana (<i>Cannabis indica</i> and <i>Cannabis sativa</i>)? | Pizzorno J | β | 2016 | β |
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| Advances in CNS Imaging Agents: Focus on PET and SPECT Tracers in Experimental and Clinical Use. | George N et al. | β | 2015 | β |
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| Avicenna's Canon of Medicine: a review of analgesics and anti-inflammatory substances. | Mahdizadeh S et al. | β | 2015 | β |
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| Brain membrane lipids in major depression and anxiety disorders. | MΓΌller CP et al. | β | 2015 | β |
| Cannabidiol as a Potential Treatment for Anxiety Disorders. | Blessing EM et al. | β | 2015 | β |
| Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence. | Lisboa SF et al. | β | 2015 | β |
| Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice. | Mereu M et al. | β | 2015 | β |
| Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hypothalamus. | Zou S et al. | β | 2015 | β |
| Deviance detection in auditory subcortical structures: what can we learn from neurochemistry and neural connectivity? | Duque D et al. | β | 2015 | β |
| Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. | Katz PS et al. | β | 2015 | β |
| Endocannabinoids and striatal function: implications for addiction-related behaviours. | Moreira FA et al. | β | 2015 | β |
| Endocannabinoids Induce Lateral Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission. | GΓ³mez-Gonzalo M et al. | β | 2015 | β |
| Endocannabinoids in Multiple Sclerosis and Amyotrophic Lateral Sclerosis. | Pryce G et al. | β | 2015 | β |
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| Gene-specific disruption of endocannabinoid receptor 1 (cnr1a) by ethanol probably leads to the development of fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish (Oryzias latipes) embryogenesis. | Dasmahapatra AK et al. | β | 2015 | β |
| Hydrogen-bonded His93 as a sensitive probe for identifying inhibitors of the endocannabinoid transport protein FABP7. | Tyukhtenko S et al. | β | 2015 | β |
| Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. | Lisboa SF et al. | β | 2015 | β |
| In vivo imaging of the cannabinoid CB1 receptor with positron emission tomography. | Hirvonen J | β | 2015 | β |
| Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | Aliczki M et al. | β | 2015 | β |
| MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors. | Irie T et al. | β | 2015 | β |
| Marijuana: a time-honored but untested treatment for epilepsy. | McLachlan RS | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice. | Hu SS et al. | β | 2015 | β |
| Medical Use of Marijuana: Truth in Evidence. | Naguib M et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Part II: Strain- and sex-specific effects of adolescent exposure to THC on adult brain and behaviour: Variants of learning, anxiety and volumetric estimates. | Keeley RJ et al. | β | 2015 | β |
| Postsynaptic Depolarization Enhances GABA Drive to Dorsomedial Hypothalamic Neurons through Somatodendritic Cholecystokinin Release. | Crosby KM et al. | β | 2015 | β |
| Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection. | More SV et al. | β | 2015 | β |
| Providing a food reward reduces inhibitory avoidance learning in zebrafish. | Manuel R et al. | β | 2015 | β |
| Psyclones: a roller coaster of life? Hidden synthetic cannabinoids and stimulants in apparently harmless products. | Santacroce R et al. | β | 2015 | β |
| Synaptic plasticity in the auditory system: a review. | Friauf E et al. | β | 2015 | β |
| The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects. | van Amsterdam J et al. | β | 2015 | β |
| The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. | McAllister SD et al. | β | 2015 | β |
| The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects. | Erdozain AM et al. | β | 2015 | β |
| The psychosis-like effects of Ξ(9)-tetrahydrocannabinol are associated with increased cortical noise in healthy humans. | Cortes-Briones JA et al. | β | 2015 | β |
| Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals. | Lenkey N et al. | β | 2015 | β |
| Ξ9-THC Disrupts Gamma (Ξ³)-Band Neural Oscillations in Humans. | Cortes-Briones J et al. | β | 2015 | β |
| Astrocytes in endocannabinoid signalling. | Navarrete M et al. | β | 2014 | β |
| Behavioral addictions: a novel challenge for psychopharmacology. | Marazziti D et al. | β | 2014 | β |
| Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system. | HernangΓ³mez M et al. | β | 2014 | β |
| Cannabinoid modulation of predator fear: involvement of the dorsolateral periaqueductal gray. | Lisboa SF et al. | β | 2014 | β |
| Cannabinoid receptor type 1 immunoreactivity and disease severity in human epithelial ovarian tumors. | Messalli EM et al. | β | 2014 | β |
| Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future. | Panagis G et al. | β | 2014 | β |
| Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic. | Aso E et al. | β | 2014 | β |
| Cannabis and psychosis: Neurobiology. | Shrivastava A et al. | β | 2014 | β |
| Cell-specific retrograde signals mediate antiparallel effects of angiotensin II on osmoreceptor afferents to vasopressin and oxytocin neurons. | Stachniak TJ et al. | β | 2014 | β |
| Differential effects and potential adverse outcomes of ionic silver and silver nanoparticles in vivo and in vitro. | Garcia-Reyero N et al. | β | 2014 | β |
| Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy. | Ma L et al. | β | 2014 | β |
| Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: the SHR strain. | Almeida V et al. | β | 2014 | β |
| Effects of pubertal cannabinoid administration on attentional set-shifting and dopaminergic hyper-responsivity in a developmental disruption model of schizophrenia. | Gomes FV et al. | β | 2014 | β |
| Endocannabinoid modulation of cortical up-states and NREM sleep. | Pava MJ et al. | β | 2014 | β |
| Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats. | De Carvalho CR et al. | β | 2014 | β |
| Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice. | Subbanna S et al. | β | 2014 | β |
| FAAH selectively influences placebo effects. | PeciΓ±a M et al. | β | 2014 | β |
| Glucocorticoid receptor antagonism disrupts the reconsolidation of social reward-related memories in rats. | Achterberg EJ et al. | β | 2014 | β |
| Gone to Pot - A Review of the Association between Cannabis and Psychosis. | Radhakrishnan R et al. | β | 2014 | β |
| Impact of stress on prefrontal glutamatergic, monoaminergic and cannabinoid systems. | Lapiz-Bluhm MD | β | 2014 | β |
| In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors. | Tsujikawa T et al. | β | 2014 | β |
| Involvement of the endocannabinoid system in osteoarthritis pain. | La Porta C et al. | β | 2014 | β |
| Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels. | Carta M et al. | β | 2014 | β |
| Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS. | Gandhi AS et al. | β | 2014 | β |
| More surprises lying ahead. The endocannabinoids keep us guessing. | Piomelli D | β | 2014 | β |
| Release of endogenous cannabinoids from ventral tegmental area dopamine neurons and the modulation of synaptic processes. | Wang H et al. | β | 2014 | β |
| Retrograde signaling causes excitement. | Schmitz D et al. | β | 2014 | β |
| Small animal PET imaging of the type 1 cannabinoid receptor in a rodent model for anorexia nervosa. | Casteels C et al. | β | 2014 | β |
| St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood. | Tantra M et al. | β | 2014 | β |
| Tales from the dark side: do neuromodulators of drug withdrawal require changes in endocannabinoid tone? | Oleson EB et al. | β | 2014 | β |
| The endocannabinoid system: directing eating behavior and macronutrient metabolism. | Watkins BA et al. | β | 2014 | β |
| Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen long-fin zebrafish: stronger effects in the resting phase than in the active phase. | Manuel R et al. | β | 2014 | β |
| A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition. | Zachariou M et al. | β | 2013 | β |
| Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | Pascual AC et al. | β | 2013 | β |
| Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. | Sylantyev S et al. | β | 2013 | β |
| Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal. | Scavone JL et al. | β | 2013 | β |
| Cannabis, psychosis and the thalamus: a theoretical review. | Vukadinovic Z et al. | β | 2013 | β |
| CB1 cannabinoid receptor-mediated aggressive behavior. | Rodriguez-Arias M et al. | β | 2013 | β |
| Central functional response to the novel peptide cannabinoid, hemopressin. | Dodd GT et al. | β | 2013 | β |
| Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats. | Lisboa SF et al. | β | 2013 | β |
| Delta-9-tetrahydrocannabinol-induced dopamine release as a function of psychosis risk: 18F-fallypride positron emission tomography study. | Kuepper R et al. | β | 2013 | β |
| Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth. | Li Z et al. | β | 2013 | β |
| Dissociation of the pharmacological effects of THC by mTOR blockade. | Puighermanal E et al. | β | 2013 | β |
| Does Cannabidiol Protect Against Adverse Psychological Effects of THC? | Niesink RJ et al. | β | 2013 | β |
| Effects of cannabis use status on cognitive function, in males with schizophrenia. | Rabin RA et al. | β | 2013 | β |
| Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats. | MΓ©ndez-DΓaz M et al. | β | 2013 | β |
| Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus. | Prestifilippo JP et al. | β | 2013 | β |
| Epigenetic mechanisms and endocannabinoid signalling. | D'Addario C et al. | β | 2013 | β |
| First characterization of AKB-48 metabolism, a novel synthetic cannabinoid, using human hepatocytes and high-resolution mass spectrometry. | Gandhi AS et al. | β | 2013 | β |
| Glial control of endocannabinoid heterosynaptic modulation in hypothalamic magnocellular neuroendocrine cells. | Di S et al. | β | 2013 | β |
| Increased expression of cannabinoid receptor 1 in the nucleus accumbens core in a rat model with morphine withdrawal. | Yuan WX et al. | β | 2013 | β |
| Increased ventral striatal CB1 receptor binding is related to negative symptoms in drug-free patients with schizophrenia. | Ceccarini J et al. | β | 2013 | β |
| In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse. | MΓ‘thΓ© D et al. | β | 2013 | β |
| Involvement of the CA1 GABAA receptors in ACPA-induced impairment of spatial and non-spatial novelty detection in mice. | Yousefi B et al. | β | 2013 | β |
| Involvement of the opioid and cannabinoid systems in pain control: new insights from knockout studies. | Nadal X et al. | β | 2013 | β |
| Lack of interaction of endocannabinoids and 5-HT(3) neurotransmission in associative fear circuits of the amygdala: evidence from electrophysiological and behavioural experiments. | HΓΆfelmann D et al. | β | 2013 | β |
| MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. | Onwuameze OE et al. | β | 2013 | β |
| Modulation of sweet responses of taste receptor cells. | Yoshida R et al. | β | 2013 | β |
| Novel song-stimulated dendritic spine formation and Arc/Arg3.1 expression in zebra finch auditory telencephalon are disrupted by cannabinoid agonism. | Gilbert MT et al. | β | 2013 | β |
| Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity. | Campolongo P et al. | β | 2013 | β |
| Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. | Cristino L et al. | β | 2013 | β |
| Orexin neurons use endocannabinoids to break obesity-induced inhibition. | AlpΓ‘r A et al. | β | 2013 | β |
| PUFA-derived endocannabinoids: an overview. | Cascio MG | β | 2013 | β |
| Recent molecular approaches to understanding astrocyte function in vivo. | Davila D et al. | β | 2013 | β |
| Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. | Hirvonen J et al. | β | 2013 | β |
| Sensory gating, cannabinoids and schizophrenia. | Dissanayake DW et al. | β | 2013 | β |
| The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care. | Bar-Sela G et al. | β | 2013 | β |
| The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects. | Zogopoulos P et al. | β | 2013 | β |
| The role of endocannabinoids in pain modulation. | Zogopoulos P et al. | β | 2013 | β |
| Transport of endocannabinoids across the plasma membrane and within the cell. | Fowler CJ | β | 2013 | β |
| Using dopamine research to generate rational cannabinoid drug policy. | Loewinger GC et al. | β | 2013 | β |
| Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury. | Lara-Celador I et al. | β | 2013 | β |
| Ξ³-Amino butyric acid and glutamate abnormalities in adolescent chronic marijuana smokers. | Prescot AP et al. | β | 2013 | β |
| A brain on cannabinoids: the role of dopamine release in reward seeking. | Oleson EB et al. | β | 2012 | β |
| Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices. | Zhang B et al. | β | 2012 | β |
| Adenosine A(2A)-cannabinoid CB(1) receptor interaction: an integrative mechanism in striatal glutamatergic neurotransmission. | Tebano MT et al. | β | 2012 | β |
| Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus. | Nicoll G et al. | β | 2012 | β |
| Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain. | Weston-Green K et al. | β | 2012 | β |
| An introduction to a symposium dedicated to the scientific achievements of Roger Nicoll. | Jahr C et al. | β | 2012 | β |
| A novel monoclonal antibody against cannabinoid receptor 1. | Kuang X et al. | β | 2012 | β |
| A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. | Edwards JG et al. | β | 2012 | β |
| Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells. | Xie C et al. | β | 2012 | β |
| A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion. | Sideris A et al. | β | 2012 | β |
| Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo. | Jacob W et al. | β | 2012 | β |
| Cannabinoid receptor activation disrupts the internal structure of hippocampal sharp wave-ripple complexes. | Sun Y et al. | β | 2012 | β |
| Cannabinoid receptor type 2 (CB2)-selective N-aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation. | RΓΌhl T et al. | β | 2012 | β |
| Cannabinoids and value-based decision making: implications for neurodegenerative disorders. | Lee AM et al. | β | 2012 | β |
| Cannabinoids disrupt hippocampal sharp wave-ripples via inhibition of glutamate release. | Maier N et al. | β | 2012 | β |
| CB1 receptor antagonism/inverse agonism increases motor system excitability in humans. | Oliviero A et al. | β | 2012 | β |
| CB1 receptor antagonists: new discoveries leading to new perspectives. | Kirilly E et al. | β | 2012 | β |
| CB1 receptor-deficient mice as a model for depression. | Valverde O et al. | β | 2012 | β |
| Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. | Puighermanal E et al. | β | 2012 | β |
| Cerebrospinal fluid biomarker candidates of schizophrenia: where do we stand? | Vasic N et al. | β | 2012 | β |
| Cortical basket cell dysfunction in schizophrenia. | Curley AA et al. | β | 2012 | β |
| Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats. | Hegyi Z et al. | β | 2012 | β |
| Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. | Lisboa SF et al. | β | 2012 | β |
| Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray. | Wilson-Poe AR et al. | β | 2012 | β |
| Effects of Ξ9-tetrahydrocannabinol administration on human encoding and recall memory function: a pharmacological FMRI study. | Bossong MG et al. | β | 2012 | β |
| Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. | Umathe SN et al. | β | 2012 | β |
| Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis. | Hill MN et al. | β | 2012 | β |
| Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. | Oleson EB et al. | β | 2012 | β |
| Enhancement of the behavioral effects of endogenous and exogenous cannabinoid agonists by phenylmethyl sulfonyl fluoride. | Vann RE et al. | β | 2012 | β |
| Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. | Song J et al. | β | 2012 | β |
| Interactions between the cannabinoid and dopaminergic systems: evidence from animal studies. | El Khoury MA et al. | β | 2012 | β |
| Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats. | Varga B et al. | β | 2012 | β |
| Introduction to the special issue on stress, emotional behavior, and the endocannabinoid system: a decade of research. | Hill MN | β | 2012 | β |
| Latest advances in novel cannabinoid CB(2) ligands for drug abuse and their therapeutic potential. | Yang P et al. | β | 2012 | β |
| Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors. | Ferreira-Junior NC et al. | β | 2012 | β |
| Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence. | Passie T et al. | β | 2012 | β |
| Modulating the modulators: interaction of brain norepinephrine and cannabinoids in stress. | Morilak DA | β | 2012 | β |
| Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus. | Ievglevskyi O et al. | β | 2012 | β |
| Neuroimaging evidence for cannabinoid modulation of cognition and affect in man. | Bhattacharyya S et al. | β | 2012 | β |
| Pathological plasticity in fragile X syndrome. | Martin BS et al. | β | 2012 | β |
| Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo. | Van Laere K et al. | β | 2012 | β |
| Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. | Gyombolai P et al. | β | 2012 | β |
| Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. | Hirvonen J et al. | β | 2012 | β |
| Role of TRPV1 in consolidation of fear memories depends on the averseness of the conditioning procedure. | Genro BP et al. | β | 2012 | β |
| Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor. | Pendri A et al. | β | 2012 | β |
| Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells. | Keimpema E et al. | β | 2012 | β |
| The decrease of dopamine Dβ/Dβ receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CBβ cannabinoid receptors in Parkinson's disease: a preliminary autoradiographic study with the selective dopamine Dβ/Dβ antagonist [Β³H]raclopride and the novel CBβ inverse agonist [ΒΉΒ²β΅I]SD7015. | Farkas S et al. | β | 2012 | β |
| The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat. | Assareh N et al. | β | 2012 | β |
| The endocannabinoid system in anxiety, fear memory and habituation. | Ruehle S et al. | β | 2012 | β |
| The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness. | Campolongo P et al. | β | 2012 | β |
| Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks. | Gonzalez-Islas C et al. | β | 2012 | β |
| Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference. | Daza-Losada M et al. | β | 2011 | β |
| Alkamides activate jasmonic acid biosynthesis and signaling pathways and confer resistance to Botrytis cinerea in Arabidopsis thaliana. | MΓ©ndez-Bravo A et al. | β | 2011 | β |
| AM251, cannabinoids receptors ligand, improves recognition memory in rats. | Bialuk I et al. | β | 2011 | β |
| Assortment of GABAergic plasticity in the cortical interneuron melting pot. | MΓ©ndez P et al. | β | 2011 | β |
| Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism. | Oh KJ et al. | β | 2011 | β |
| Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa. | GΓ©rard N et al. | β | 2011 | β |
| Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury. | Alonso-Alconada D et al. | β | 2011 | β |
| Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice. | Wiskerke J et al. | β | 2011 | β |
| Cannabinoid CB1 receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats. | Fang Q et al. | β | 2011 | β |
| Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. | Di Marzo V et al. | β | 2011 | β |
| Cannabinoid system and cyclooxygenases inhibitors. | PΔunescu H et al. | β | 2011 | β |
| Comparison of Cannabinoid CB(1) Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [F]MK-9470. | Verdurand M et al. | β | 2011 | β |
| Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal. | Ripley TL et al. | β | 2011 | β |
| Distribution of CB2 cannabinoid receptor in adult rat retina. | LΓ³pez EM et al. | β | 2011 | β |
| Effects of cannabinoid CBβ receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice. | Yu LL et al. | β | 2011 | β |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | β | 2011 | β |
| Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. | Sidhpura N et al. | β | 2011 | β |
| Endocannabinoid modulation of sympathetic and cardiovascular responses to acute stress in the periaqueductal gray of the rat. | Dean C | β | 2011 | β |
| Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. | Crosby KM et al. | β | 2011 | β |
| Fragile X syndrome: the GABAergic system and circuit dysfunction. | Paluszkiewicz SM et al. | β | 2011 | β |
| Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. | Lin QS et al. | β | 2011 | β |
| Immediate effect on pain thresholds using active release technique on adductor strains: Pilot study. | Robb A et al. | β | 2011 | β |
| In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis. | Goffin K et al. | β | 2011 | β |
| Involvement of dorsal hippocampal Ξ±1-adrenergic receptors in the effect of WIN55,212-2 on memory retrieval in inhibitory avoidance task. | Moshfegh A et al. | β | 2011 | β |
| Involvement of the endocannabinoid system in alcohol dependence: the biochemical, behavioral and genetic evidence. | Erdozain AM et al. | β | 2011 | β |
| Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis. | Tasker JG et al. | β | 2011 | β |
| Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation. | Iravani MM et al. | β | 2011 | β |
| Methods of the pharmacological imaging of the cannabinoid system (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition. | van Hell HH et al. | β | 2011 | β |
| Molecular model of cannabis sensitivity in developing neuronal circuits. | Keimpema E et al. | β | 2011 | β |
| N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. | Donohue SR et al. | β | 2011 | β |
| Neurochemical basis of cannabis addiction. | Maldonado R et al. | β | 2011 | β |
| Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity. | Blaazer AR et al. | β | 2011 | β |
| Pharmacogenetics of new analgesics. | LΓΆtsch J et al. | β | 2011 | β |
| Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy. | KarlΓ³cai MR et al. | β | 2011 | β |
| Review: The neuropathology of drug abuse. | BΓΌttner A | β | 2011 | β |
| Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies. | Ward SJ et al. | β | 2011 | β |
| Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. | Chen M et al. | β | 2011 | β |
| Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala. | Kamprath K et al. | β | 2011 | β |
| Spinal cord injuries induce changes in CB1 cannabinoid receptor and C-C chemokine expression in brain areas underlying circuitry of chronic pain conditions. | Knerlich-Lukoschus F et al. | β | 2011 | β |
| Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses. | Sedlacek M et al. | β | 2011 | β |
| The distinct role of medium spiny neurons and cholinergic interneurons in the Dβ/AβA receptor interaction in the striatum: implications for Parkinson's disease. | Tozzi A et al. | β | 2011 | β |
| Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia. | Bossong MG et al. | β | 2010 | β |
| Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. | Greco R et al. | β | 2010 | β |
| Anxiety-like behavior induced by histaminergic agents can be prevented by cannabinoidergic WIN55,212-2 injected into the dorsal hippocampus in mice. | Zarrindast MR et al. | β | 2010 | β |
| Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats. | Zavitsanou K et al. | β | 2010 | β |
| Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization. | Zhang G et al. | β | 2010 | β |
| Cannabinoid effects on CB1 receptor density in the adolescent brain: an autoradiographic study using the synthetic cannabinoid HU210. | Dalton VS et al. | β | 2010 | β |
| Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. | Bhaskaran MD et al. | β | 2010 | β |
| Cannabinoids and Dementia: A Review of Clinical and Preclinical Data. | Walther S et al. | β | 2010 | β |
| Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. | Schlosburg JE et al. | β | 2010 | β |
| Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor. | Crombag HS et al. | β | 2010 | β |
| Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. | Laaris N et al. | β | 2010 | β |
| Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks. | Hlinka J et al. | β | 2010 | β |
| Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex. | Eggan SM et al. | β | 2010 | β |
| Differential sensitivity of A2A and especially D2 receptor trafficking to cocaine compared with lipid rafts in cotransfected CHO cell lines. Novel actions of cocaine independent of the DA transporter. | Genedani S et al. | β | 2010 | β |
| Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. | Dalton VS et al. | β | 2010 | β |
| Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist. | Hung MS et al. | β | 2010 | β |
| Effects of abnormal cannabidiol on oxytocin-induced myometrial contractility. | Houlihan DD et al. | β | 2010 | β |
| Endocannabinoid (EC) receptor, CB1, and EC enzymes' expression in primary adipocyte cultures of lean and obese pre-pubertal children in relation to adiponectin and insulin. | Karvela A et al. | β | 2010 | β |
| Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance. | Finn DP | β | 2010 | β |
| Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes. | Navarrete M et al. | β | 2010 | β |
| Endocannabinoids selectively enhance sweet taste. | Yoshida R et al. | β | 2010 | β |
| Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output. | Hill MN et al. | β | 2010 | β |
| Interactions between specific parameters of cannabis use and verbal memory. | Wagner D et al. | β | 2010 | β |
| Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats. | Lemos JI et al. | β | 2010 | β |
| Lipid profiling reveals tissue-specific differences for ethanolamide lipids in mice lacking fatty acid amide hydrolase. | Kilaru A et al. | β | 2010 | β |
| Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells. | Li Q et al. | β | 2010 | β |
| Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment. | Vizi ES et al. | β | 2010 | β |
| Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia. | Son TG et al. | β | 2010 | β |
| Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls. | Buczynski MW et al. | β | 2010 | β |
| Reciprocal modulation of sweet taste by leptin and endocannabinoids. | Niki M et al. | β | 2010 | β |
| Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Delta9-THC exposure-impaired hippocampal synaptic plasticity. | Fan N et al. | β | 2010 | β |
| Regulation of subthalamic neuron activity by endocannabinoids. | Morera-Herreras T et al. | β | 2010 | β |
| Second-order schedules of nicotine reinforcement in rats: effect of AM251. | Wing VC et al. | β | 2010 | β |
| Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge. | Stokes PR et al. | β | 2010 | β |
| Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory. | de Oliveira Alvares L et al. | β | 2010 | β |
| The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain. | Casteels C et al. | β | 2010 | β |
| The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats. | Walsh S et al. | β | 2010 | β |
| Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. | Tebano MT et al. | β | 2009 | β |
| Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. | Dowie MJ et al. | β | 2009 | β |
| Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. | Fernandez-Solari J et al. | β | 2009 | β |
| Anandamide receptor signal transduction. | Goodfellow CE et al. | β | 2009 | β |
| Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions. | Fong TM et al. | β | 2009 | β |
| Cannabinoid receptor CB1 antagonists state of the art and challenges. | Bifulco M et al. | β | 2009 | β |
| Cannabinoids in the treatment of cancer. | Alexander A et al. | β | 2009 | β |
| Cannabis and psychosis/schizophrenia: human studies. | D'Souza DC et al. | β | 2009 | β |
| Cannabis-based treatment induces polarity-reversing plasticity assessed by theta burst stimulation in humans. | Koch G et al. | β | 2009 | β |
| Can recreational doses of THC produce significant dopamine release in the human striatum? | Stokes PR et al. | β | 2009 | β |
| Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat. | Dodd GT et al. | β | 2009 | β |
| Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. | Russell DW et al. | β | 2009 | β |
| Discovery and functional evaluation of diverse novel human CB(1) receptor ligands. | Foloppe N et al. | β | 2009 | β |
| Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT. | Bhatti AS et al. | β | 2009 | β |
| Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice. | Yu LL et al. | β | 2009 | β |
| Effects of cannabinoids infused into the dorsal hippocampus upon memory formation in 3-days apomorphine-treated rats. | Nasehi M et al. | β | 2009 | β |
| Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. | Penzo MA et al. | β | 2009 | β |
| Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex. | Li L et al. | β | 2009 | β |
| Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. | Koppel J et al. | β | 2009 | β |
| Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. | Kamprath K et al. | β | 2009 | β |
| Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors. | Umathe SN et al. | β | 2009 | β |
| Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. | Basavarajappa BS et al. | β | 2009 | β |
| Endogenous ethanolamide analysis in human plasma using HPLC tandem MS with electrospray ionization. | Palandra J et al. | β | 2009 | β |
| Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways. | Di S et al. | β | 2009 | β |
| Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic-pituitary-adrenal axis. | Gorzalka BB et al. | β | 2009 | β |
| Involvement of hypothalamic peptides in the anorectic action of the CB receptor antagonist rimonabant (SR 141716). | Verty AN et al. | β | 2009 | β |
| Latest advances in cannabinoid receptor agonists. | Thakur GA et al. | β | 2009 | β |
| Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. | Gkini E et al. | β | 2009 | β |
| Neuronal and glial localization of the cannabinoid-1 receptor in the superficial spinal dorsal horn of the rodent spinal cord. | Hegyi Z et al. | β | 2009 | β |
| Origin, early commitment, migratory routes, and destination of cannabinoid type 1 receptor-containing interneurons. | Morozov YM et al. | β | 2009 | β |
| Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat. | Timofeeva E et al. | β | 2009 | β |
| Presynaptic cell dependent modulation of inhibition in cortical regions. | Ali AB | β | 2009 | β |
| Role of cannabis and endocannabinoids in the genesis of schizophrenia. | Fernandez-Espejo E et al. | β | 2009 | β |
| Role of endocannabinoids and endovanilloids in Ca2+ signalling. | De Petrocellis L et al. | β | 2009 | β |
| Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations. | Edwards CR et al. | β | 2009 | β |
| Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory. | Di Filippo M et al. | β | 2009 | β |
| Synaptic plasticity in the basal ganglia. | Wickens JR | β | 2009 | β |
| The endocannabinoid system and pain. | Guindon J et al. | β | 2009 | β |
| The endocannabinoid system as a target for modelling psychosis. | Koethe D et al. | β | 2009 | β |
| The genetics of episodic memory. | Koppel J et al. | β | 2009 | β |
| Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. | Lisboa SF et al. | β | 2008 | β |
| Additive interaction of the cannabinoid receptor I agonist arachidonyl-2-chloroethylamide with etomidate in a sedation model in mice. | Meybohm P et al. | β | 2008 | β |
| A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. | Goncalves MB et al. | β | 2008 | β |
| Advances in the field of cannabinoid--opioid cross-talk. | Robledo P et al. | β | 2008 | β |
| A neuropeptide-centric view of psychostimulant addiction. | Boutrel B | β | 2008 | β |
| An in vivo [18F]MK-9470 microPET study of type 1 cannabinoid receptor binding in Wistar rats after chronic administration of valproate and levetiracetam. | Goffin K et al. | β | 2008 | β |
| Auditory gating in rat hippocampus and medial prefrontal cortex: effect of the cannabinoid agonist WIN55,212-2. | Dissanayake DW et al. | β | 2008 | β |
| Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. | Kotti T et al. | β | 2008 | β |
| Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies. | Le Foll B et al. | β | 2008 | β |
| Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats. | Biala G et al. | β | 2008 | β |
| Cannabinoid sensitivity and synaptic properties of 2 GABAergic networks in the neocortex. | Galarreta M et al. | β | 2008 | β |
| Cannabis and psychiatric disorders: it is not only addiction. | Leweke FM et al. | β | 2008 | β |
| Cannabis, cannabinoids and schizophrenia: integration of the evidence. | Cohen M et al. | β | 2008 | β |
| CB(1) cannabinoid receptor activation dose dependently modulates neuronal activity within caudal but not rostral song control regions of adult zebra finch telencephalon. | Soderstrom K et al. | β | 2008 | β |
| CB(1) receptor antagonism: biological basis for metabolic effects. | Di Marzo V | β | 2008 | β |
| COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity. | Yang H et al. | β | 2008 | β |
| Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol. | Deutsch SI et al. | β | 2008 | β |
| Cyclooxygenase-2 in synaptic signaling. | Yang H et al. | β | 2008 | β |
| Degradation of endocannabinoids in chronic migraine and medication overuse headache. | Cupini LM et al. | β | 2008 | β |
| Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons. | Sano K et al. | β | 2008 | β |
| Dendritic excitability and synaptic plasticity. | SjΓΆstrΓΆm PJ et al. | β | 2008 | β |
| Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms. | De Oliveira Alvares L et al. | β | 2008 | β |
| Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. | Kurjak M et al. | β | 2008 | β |
| Does cannabis use lead to depression and suicidal behaviours? A population-based longitudinal study. | Pedersen W | β | 2008 | β |
| Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. | LudΓ‘nyi A et al. | β | 2008 | β |
| Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | Ellgren M et al. | β | 2008 | β |
| Endocannabinoid signaling in the spinal locomotor circuitry. | El Manira A et al. | β | 2008 | β |
| Endocannabinoids mediate neuron-astrocyte communication. | Navarrete M et al. | β | 2008 | β |
| Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals. | Nyilas R et al. | β | 2008 | β |
| Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats. | Malinen H et al. | β | 2008 | β |
| Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice. | Naderi N et al. | β | 2008 | β |
| Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. | Van Laere K et al. | β | 2008 | β |
| Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation. | Camilleri M et al. | β | 2008 | β |
| Glutamatergic transmission and plasticity between olfactory bulb mitral cells. | Pimentel DO et al. | β | 2008 | β |
| High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. | Widmer M et al. | β | 2008 | β |
| Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats. | Robinson L et al. | β | 2008 | β |
| Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. | SuΓ‘rez J et al. | β | 2008 | β |
| Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment. | Zarate J et al. | β | 2008 | β |
| Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. | Cippitelli A et al. | β | 2008 | β |
| Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. | Duan Y et al. | β | 2008 | β |
| Long lasting consequences of cannabis exposure in adolescence. | Rubino T et al. | β | 2008 | β |
| Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: plasticity-induced changes that could underlie tinnitus. | Tzounopoulos T | β | 2008 | β |
| Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus. | Edwards DA et al. | β | 2008 | β |
| Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. | Morgan NH et al. | β | 2008 | β |
| Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. | Haller VL et al. | β | 2008 | β |
| Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders. | Di Filippo M et al. | β | 2008 | β |
| Neuronuclear assessment of patients with epilepsy. | Goffin K et al. | β | 2008 | β |
| Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction. | de Oliveira Alvares L et al. | β | 2008 | β |
| Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. | Nallapaneni A et al. | β | 2008 | β |
| Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. | Woolmore J et al. | β | 2008 | β |
| Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders. | Gorzalka BB et al. | β | 2008 | β |
| Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus. | Yasuda H et al. | β | 2008 | β |
| Role of cannabinoid receptors in the control of gastrointestinal motility and perception. | Fioramonti J et al. | β | 2008 | β |
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| Strength through diversity. | Nelson SB et al. | β | 2008 | β |
| Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. | Yang Z et al. | β | 2008 | β |
| Synaptic plasticity: multiple forms, functions, and mechanisms. | Citri A et al. | β | 2008 | β |
| Targeting the endocannabinoid system in Alzheimer's disease. | Koppel J et al. | β | 2008 | β |
| Temporal and site-specific brain alterations in CB1 receptor binding in high fat diet-induced obesity in C57Bl/6 mice. | South T et al. | β | 2008 | β |
| The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets. | Bambico FR et al. | β | 2008 | β |
| The cannabinoid CB1 receptor antagonist rimonabant dose-dependently inhibits memory recall in the passive avoidance task in domestic chicks (Gallus domesticus). | AdΓ‘m AS et al. | β | 2008 | β |
| The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons. | Lau T et al. | β | 2008 | β |
| The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [(3)H]batrachotoxinin A 20 alpha-benzoate binding to sodium channels and inhibit sodium channel function. | Duan Y et al. | β | 2008 | β |
| The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation. | Watson S et al. | β | 2008 | β |
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| Transsynaptic modulation of the synaptic vesicle cycle by cell-adhesion molecules. | Gottmann K | β | 2008 | β |
| Understanding synapses: past, present, and future. | SΓΌdhof TC et al. | β | 2008 | β |
| Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects. | Van Laere K et al. | β | 2008 | β |
| An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives. | Fattore L et al. | β | 2007 | β |
| Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents. | Fong TM et al. | β | 2007 | β |
| Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. | Moreira FA et al. | β | 2007 | β |
| BfCBR: a cannabinoid receptor ortholog in the cephalochordate Branchiostoma floridae (Amphioxus). | Elphick MR | β | 2007 | β |
| Cannabinoid control of neuroinflammation related to multiple sclerosis. | Baker D et al. | β | 2007 | β |
| Cannabinoid-mediated disinhibition and working memory: dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex. | Carter E et al. | β | 2007 | β |
| Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal. | Huang H et al. | β | 2007 | β |
| Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia? | Solowij N et al. | β | 2007 | β |
| CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors. | Mato S et al. | β | 2007 | β |
| CB1 receptors diminish both Ca(2+) influx and glutamate release through two different mechanisms active in distinct populations of cerebrocortical nerve terminals. | Godino Mdel C et al. | β | 2007 | β |
| Coactivation of pre- and postsynaptic signaling mechanisms determines cell-specific spike-timing-dependent plasticity. | Tzounopoulos T et al. | β | 2007 | β |
| Conformationally constrained analogues of 2-arachidonoylglycerol. | Vadivel SK et al. | β | 2007 | β |
| Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. | Pryce G et al. | β | 2007 | β |
| Cytokinin receptors are involved in alkamide regulation of root and shoot development in Arabidopsis. | LΓ³pez-Bucio J et al. | β | 2007 | β |
| Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. | Oka S et al. | β | 2007 | β |
| Endocannabinoid liberation from neurons in transsynaptic signaling. | Lovinger DM | β | 2007 | β |
| Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. | Chevaleyre V et al. | β | 2007 | β |
| Endocannabinoids and the control of energy balance. | Matias I et al. | β | 2007 | β |
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| Endocannabinoids in basal ganglia circuits: implications for Parkinson disease. | Benarroch E | β | 2007 | β |
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| Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. | Newman Z et al. | β | 2007 | β |
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| Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression. | Koethe D et al. | β | 2007 | β |
| Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. | Jacobsen LK et al. | β | 2007 | β |
| Functional dissection of circuitry in a neural integrator. | Aksay E et al. | β | 2007 | β |
| Homosynaptic and heterosynaptic modes of endocannabinoid action at hippocampal CCK+ basket cell synapses. | Lawrence JJ | β | 2007 | β |
| Inhibitors of monoacylglycerol lipase as novel analgesics. | Hohmann AG | β | 2007 | β |
| Integrated physiology and pathophysiology of CB1-mediated effects of the endocannabinoid system. | Piazza PV et al. | β | 2007 | β |
| In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans. | Van Laere K | β | 2007 | β |
| Localization of CiCBR in the invertebrate chordate Ciona intestinalis: evidence of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling. | EgertovΓ‘ M et al. | β | 2007 | β |
| Long-term plasticity of the spinal locomotor circuitry mediated by endocannabinoid and nitric oxide signaling. | Kyriakatos A et al. | β | 2007 | β |
| Message in a bottle: long-range retrograde signaling in the nervous system. | IbÑñez CF | β | 2007 | β |
| Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence. | Tanda G | β | 2007 | β |
| neuroConstruct: a tool for modeling networks of neurons in 3D space. | Gleeson P et al. | β | 2007 | β |
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| Neuroprotective and intraocular pressure-lowering effects of (-)Delta9-tetrahydrocannabinol in a rat model of glaucoma. | Crandall J et al. | β | 2007 | β |
| Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation. | Hoffman AF et al. | β | 2007 | β |
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| Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. | Deshmukh S et al. | β | 2007 | β |
| Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. | Marsch R et al. | β | 2007 | β |
| Rimonabant: a novel approach for the treatment of obesity and cardiometabolic risk by blockade of the endocannabinoid system. | Colleran K et al. | β | 2007 | β |
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| Role of cortical cannabinoid CB1 receptor in conditioned taste aversion memory. | Kobilo T et al. | β | 2007 | β |
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| The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use. | Xie S et al. | β | 2007 | β |
| The N-acylethanolamine-mediated regulatory pathway in plants. | Kilaru A et al. | β | 2007 | β |
| The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats. | Robinson L et al. | β | 2007 | β |
| A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. | D'Antona AM et al. | β | 2006 | β |
| AM251, a selective antagonist of the CB1 receptor, inhibits the induction of long-term potentiation and induces retrograde amnesia in rats. | de Oliveira Alvares L et al. | β | 2006 | β |
| AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. | Costa B et al. | β | 2006 | β |
| Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice. | Freiman I et al. | β | 2006 | β |
| Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. | Cupini LM et al. | β | 2006 | β |
| Blockade of cannabinoid CB1 receptors alters contextual learning and memory. | Arenos JD et al. | β | 2006 | β |
| Cannabinoid-1 receptor: a novel target for the treatment of neuropsychiatric disorders. | Vinod KY et al. | β | 2006 | β |
| Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes. | Kamprath K et al. | β | 2006 | β |
| Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats. | Cheer JF et al. | β | 2006 | β |
| Cannabinoids in cancer pain management. | Huskey A | β | 2006 | β |
| Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. | Fisyunov A et al. | β | 2006 | β |
| [Delta(9)-tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain]. | Seeling W et al. | β | 2006 | β |
| Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia. | Walther S et al. | β | 2006 | β |
| Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. | Szabo B et al. | β | 2006 | β |
| Effects of exogenous and endogenous cannabinoids on GABAergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse. | Engler B et al. | β | 2006 | β |
| Endocannabinoid mechanisms of pain modulation. | Hohmann AG et al. | β | 2006 | β |
| Endocannabinoid-mediated synaptic plasticity in the CNS. | Chevaleyre V et al. | β | 2006 | β |
| Endocannabinoids: a critical regulator of activity in the developing brain. | Coulter DA | β | 2006 | β |
| Endocannabinoid system and its role in energy regulation. | Matias I et al. | β | 2006 | β |
| Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning. | Kishimoto Y et al. | β | 2006 | β |
| Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. | Matias I et al. | β | 2006 | β |
| Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. | Wettschureck N et al. | β | 2006 | β |
| Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. | Cristino L et al. | β | 2006 | β |
| Interneurons targeting similar layers receive synaptic inputs with similar kinetics. | Cossart R et al. | β | 2006 | β |
| Involvement of the endocannabinoid system in drug addiction. | Maldonado R et al. | β | 2006 | β |
| Jekyll and hyde: two faces of cannabinoid signaling in male and female fertility. | Wang H et al. | β | 2006 | β |
| Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. | Yoshida T et al. | β | 2006 | β |
| Miniature synaptic events elicited by presynaptic Ca2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. | Yamasaki M et al. | β | 2006 | β |
| Molecular composition of the endocannabinoid system at glutamatergic synapses. | Katona I et al. | β | 2006 | β |
| Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization. | D'Antona AM et al. | β | 2006 | β |
| New bicyclic cannabinoid receptor-1 (CB1-R) antagonists. | Carpino PA et al. | β | 2006 | β |
| Nitric oxide and synaptic dynamics in the adult brain: physiopathological aspects. | Moreno-LΓ³pez B et al. | β | 2006 | β |
| PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. | Sang N et al. | β | 2006 | β |
| Plant, synthetic, and endogenous cannabinoids in medicine. | Di Marzo V et al. | β | 2006 | β |
| Presence of depolarization-induced suppression of inhibition in a fraction of GABAergic synaptic connections in rat neocortical cultures. | Storozhuk MV et al. | β | 2006 | β |
| Presynaptic actions of endocannabinoids mediate alpha-MSH-induced inhibition of oxytocin cells. | Sabatier N et al. | β | 2006 | β |
| Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2. | Yoshikawa K et al. | β | 2006 | β |
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| Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors. | Gelfand EV et al. | β | 2006 | β |
| Role of the endocannabinoid system in depression and suicide. | Vinod KY et al. | β | 2006 | β |
| Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia. | MΓ‘tyΓ‘s F et al. | β | 2006 | β |
| The acute effects of cannabinoids on memory in humans: a review. | Ranganathan M et al. | β | 2006 | β |
| The diverse roles of vesicular glutamate transporter 3. | Seal RP et al. | β | 2006 | β |
| The emerging role of the endocannabinoid system in endocrine regulation and energy balance. | Pagotto U et al. | β | 2006 | β |
| The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. | Eljaschewitsch E et al. | β | 2006 | β |
| The endocannabinoid system as an emerging target of pharmacotherapy. | Pacher P et al. | β | 2006 | β |
| Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. | Bender VA et al. | β | 2006 | β |
| AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation. | Rodella LF et al. | β | 2005 | β |
| Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice. | Valverde O et al. | β | 2005 | β |
| A role for cannabinoid CB1 receptors in mood and anxiety disorders. | Witkin JM et al. | β | 2005 | β |
| A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. | Solbrig MV et al. | β | 2005 | β |
| Associative short-term synaptic plasticity mediated by endocannabinoids. | Brenowitz SD et al. | β | 2005 | β |
| A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders. | Witkin JM et al. | β | 2005 | β |
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| Cannabinoid receptors and their relationships with neuropsychiatric disorders. | Gambi F et al. | β | 2005 | β |
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| CB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors. | Houchi H et al. | β | 2005 | β |
| Central and peripheral interactions between endocannabinoids and steroids, and implications for drug dependence. | Maccarrone M | β | 2005 | β |
| Central and peripheral signaling mechanisms involved in endocannabinoid regulation of feeding: a perspective on the munchies. | Sharkey KA et al. | β | 2005 | β |
| Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. | D'Souza DC et al. | β | 2005 | β |
| Differential effects of two phospholipase D inhibitors, 1-butanol and N-acylethanolamine, on in vivo cytoskeletal organization and Arabidopsis seedling growth. | Motes CM et al. | β | 2005 | β |
| Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum. | Kreitzer AC et al. | β | 2005 | β |
| Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones. | Mukhtarov M et al. | β | 2005 | β |
| Effects of cannabinoids on neurotransmission. | Szabo B et al. | β | 2005 | β |
| Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents. | Griebel G et al. | β | 2005 | β |
| Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims. | Vinod KY et al. | β | 2005 | β |
| Emerging properties of cannabinoid medicines in management of multiple sclerosis. | Pryce G et al. | β | 2005 | β |
| Endocannabinoid lipids and mediated system: implications for alcoholism and neuropsychiatric disorders. | Vinod KY et al. | β | 2005 | β |
| Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction. | Lupica CR et al. | β | 2005 | β |
| Endocannabinoid signaling depends on the spatial pattern of synapse activation. | Marcaggi P et al. | β | 2005 | β |
| Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types. | Bodor AL et al. | β | 2005 | β |
| Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. | Glaser ST et al. | β | 2005 | β |
| Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. | Berghuis P et al. | β | 2005 | β |
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| Ephaptic feedback in identified synapses in mollusk neurons. | Bravarenko NI et al. | β | 2005 | β |
| Gene expression profiling in the hippocampus of learned helpless and nonhelpless rats. | Kohen R et al. | β | 2005 | β |
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| Identification of a high-affinity binding site involved in the transport of endocannabinoids. | Moore SA et al. | β | 2005 | β |
| Inhibition of N- and P/Q-type Ca2+ channels by cannabinoid receptors in single cerebrocortical nerve terminals. | Godino MC et al. | β | 2005 | β |
| Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. | Jo YH et al. | β | 2005 | β |
| Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists. | Lange JH et al. | β | 2005 | β |
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| Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal. | Hashimotodani Y et al. | β | 2005 | β |
| Redistribution of CB1 cannabinoid receptors during evolution of cholinergic basal forebrain territories and their cortical projection areas: a comparison between the gray mouse lemur (Microcebus murinus, primates) and rat. | Harkany T et al. | β | 2005 | β |
| Rimonabant: the first therapeutically relevant cannabinoid antagonist. | Carai MA et al. | β | 2005 | β |
| Role of lipids and lipid signaling in the development of cannabinoid tolerance. | Martin BR | β | 2005 | β |
| Search for an endogenous cannabinoid-mediated effect in the sympathetic nervous system. | Pfitzer T et al. | β | 2005 | β |
| Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A. | De Vries TJ et al. | β | 2005 | β |
| Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. | Maejima T et al. | β | 2005 | β |
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| The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze. | Takahashi RN et al. | β | 2005 | β |
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| The recent impact of solid-phase synthesis on medicinally relevant benzoannelated oxygen heterocycles. | Ziegert RE et al. | β | 2005 | β |
| Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide. | Murineddu G et al. | β | 2005 | β |
| Tuning the network: modulation of neuronal microcircuits in the spinal cord and hippocampus. | LeBeau FE et al. | β | 2005 | β |
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| 3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release. | Huang CC et al. | β | 2004 | β |
| Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons. | Pistis M et al. | β | 2004 | β |
| Analysis of the effects of cannabinoids on synaptic transmission between basket and Purkinje cells in the cerebellar cortex of the rat. | Szabo B et al. | β | 2004 | β |
| A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro. | Whalley BJ et al. | β | 2004 | β |
| Are oral cannabinoids safe and effective in refractory neuropathic pain? | Attal N et al. | β | 2004 | β |
| Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. | Covault J et al. | β | 2004 | β |
| ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. | Walter L et al. | β | 2004 | β |
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| Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. | Cheer JF et al. | β | 2004 | β |
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| Cannabinoids in multiple sclerosis: do they have a therapeutic role? | Killestein J et al. | β | 2004 | β |
| Cannabis-associated psychosis: current status of research. | Leweke FM et al. | β | 2004 | β |
| Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. | Ruiz-Llorente L et al. | β | 2004 | β |
| Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. | Azad SC et al. | β | 2004 | β |
| Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice. | Naassila M et al. | β | 2004 | β |
| Differential effects of endogenous and synthetic cannabinoids on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes. | Oz M et al. | β | 2004 | β |
| Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors. | Galarreta M et al. | β | 2004 | β |
| Endocannabinoid-mediated metaplasticity in the hippocampus. | Chevaleyre V et al. | β | 2004 | β |
| Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice. | Witting A et al. | β | 2004 | β |
| Endocannabinoids and food consumption: comparisons with benzodiazepine and opioid palatability-dependent appetite. | Cooper SJ | β | 2004 | β |
| Endocannabinoids and their implications for epilepsy. | Alger BE | β | 2004 | β |
| Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels. | Brown SP et al. | β | 2004 | β |
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| Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat. | EgertovΓ‘ M et al. | β | 2004 | β |
| Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus. | D'Amico M et al. | β | 2004 | β |
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