A HapMap harvest of insights into the genetics of common disease.
paper
Cited
Public
Unavailable
- Authors
- Manolio, Teri A; Brooks, Lisa D; Collins, Francis S
- Year
- 2008
- Journal
- The Journal of clinical investigation
- PMID
- 18451988
- DOI
- 10.1172/JCI34772
- PMCID
- PMC2336881
The International HapMap Project was designed to create a genome-wide database of patterns of human genetic variation, with the expectation that these patterns would be useful for genetic association studies of common diseases. This expectation has been amply fulfilled with just the initial output of genome-wide association studies, identifying nearly 100 loci for nearly 40 common diseases and traits. These associations provided new insights into pathophysiology, suggesting previously unsuspected etiologic pathways for common diseases that will be of use in identifying new therapeutic targets and developing targeted interventions based on genetically defined risk. In addition, HapMap-based discoveries have shed new light on the impact of evolutionary pressures on the human genome, suggesting multiple loci important for adapting to disease-causing pathogens and new environments. In this review we examine the origin, development, and current status of the HapMap; its prospects for continued evolution; and its current and potential future impact on biomedical science.
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| Inflammatory priming predisposes mice to age-related retinal degeneration. | Mustafi D et al. | โ | 2012 | โ |
| Insights into the genetic architecture of diabetic nephropathy. | Palmer ND et al. | โ | 2012 | โ |
| Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFฮฑ inhibitors in patients with rheumatoid arthritis. | Krintel SB et al. | โ | 2012 | โ |
| 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. | Fier H et al. | โ | 2012 | โ |
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| New genetic insights from autoimmune thyroid disease. | Davies TF et al. | โ | 2012 | โ |
| New routes for transgenesis of the mouse. | Belizรกrio JE et al. | โ | 2012 | โ |
| No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students. | Kou C et al. | โ | 2012 | โ |
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| Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10. | ลoniewska B et al. | โ | 2012 | โ |
| Rare and common variants: twenty arguments. | Gibson G | โ | 2012 | โ |
| Rare genetic variants and treatment response: sample size and analysis issues. | Witte JS | โ | 2012 | โ |
| Rare variants in complex traits: novel identification strategies and the role of de novo mutations. | Jouan L et al. | โ | 2012 | โ |
| Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations. | Holdt LM et al. | โ | 2012 | โ |
| Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. | Wang M et al. | โ | 2012 | โ |
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| Technical reproducibility of genotyping SNP arrays used in genome-wide association studies. | Hong H et al. | โ | 2012 | โ |
| The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies. | Grade M et al. | โ | 2012 | โ |
| The mystery of missing heritability: Genetic interactions create phantom heritability. | Zuk O et al. | โ | 2012 | โ |
| The role of large pedigrees in an era of high-throughput sequencing. | Wijsman EM | โ | 2012 | โ |
| Translational bioinformatics in psychoneuroimmunology: methods and applications. | Yan Q | โ | 2012 | โ |
| Using genome-wide association studies to identify genes important in serious adverse drug reactions. | Daly AK | โ | 2012 | โ |
| Utility-preserving transaction data anonymization with low information loss. | Loukides G et al. | โ | 2012 | โ |
| A comparison of association methods for cytotoxicity mapping in pharmacogenomics. | Brown C et al. | โ | 2011 | โ |
| A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers. | Kim DH et al. | โ | 2011 | โ |
| Alzheimer's disease genetics: current knowledge and future challenges. | Hollingworth P et al. | โ | 2011 | โ |
| An application and empirical comparison of statistical analysis methods for associating rare variants to a complex phenotype. | Bansal V et al. | โ | 2011 | โ |
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| An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. | Moskvina V et al. | โ | 2011 | โ |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | โ | 2011 | โ |
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| A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study. | Wang J et al. | โ | 2011 | โ |
| A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis. | Nakaoka H et al. | โ | 2011 | โ |
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| CDH13 is associated with working memory performance in attention deficit/hyperactivity disorder. | Arias-Vรกsquez A et al. | โ | 2011 | โ |
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| Construction of Japanese BAC library Yamato-2 (JY2): a set of 330K clone resources of damage-minimized DNA taken from a genetically established Japanese individual. | Terabayashi Y et al. | โ | 2011 | โ |
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| Contributions of dopamine-related genes and environmental factors to highly sensitive personality: a multi-step neuronal system-level approach. | Chen C et al. | โ | 2011 | โ |
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| Copy number variants on the X chromosome in women with primary ovarian insufficiency. | Knauff EA et al. | โ | 2011 | โ |
| Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. | Hoffmann TJ et al. | โ | 2011 | โ |
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| Endothelial nitric oxide synthase (eNOS) variants in cardiovascular disease: pharmacogenomic implications. | Bhanoori M | โ | 2011 | โ |
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| Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. | So HC et al. | โ | 2011 | โ |
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| Gene-environment interaction in psychological traits and disorders. | Dick DM | โ | 2011 | โ |
| Gene- or region-based association study via kernel principal component analysis. | Gao Q et al. | โ | 2011 | โ |
| Genetic analysis in cardiovascular disease: a clinical perspective. | Ho E et al. | โ | 2011 | โ |
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| Genetic association and gene-environment interaction: a new method for overcoming the lack of exposure information in controls. | Kazma R et al. | โ | 2011 | โ |
| Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease. | Daly AK et al. | โ | 2011 | โ |
| Genetic factors in contact allergy--review and future goals. | Schnuch A et al. | โ | 2011 | โ |
| Genetic modifiers of non-alcoholic fatty liver disease progression. | Anstee QM et al. | โ | 2011 | โ |
| Genetic polymorphisms of glutathione S-transferase P1 and bladder cancer susceptibility in a Chinese population. | Zhang R et al. | โ | 2011 | โ |
| Genetic polymorphisms of p53 codon 72 and bladder cancer susceptibility: a hospital-based case-control study. | Zhang R et al. | โ | 2011 | โ |
| Genetics of common forms of heart failure. | Dorn GW | โ | 2011 | โ |
| Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes. | Hakonarson H et al. | โ | 2011 | โ |
| Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. | Fornage M et al. | โ | 2011 | โ |
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| HNF1B polymorphism associated with development of prostate cancer in Korean patients. | Kim HJ et al. | โ | 2011 | โ |
| Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. | Mohammed JP et al. | โ | 2011 | โ |
| Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. | Ferreira MA et al. | โ | 2011 | โ |
| Impact of phenotype definition on genome-wide association signals: empirical evaluation in human immunodeficiency virus type 1 infection. | Evangelou E et al. | โ | 2011 | โ |
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| Inference of relationships in population data using identity-by-descent and identity-by-state. | Stevens EL et al. | โ | 2011 | โ |
| Knowledge gaining by human genetic studies on tuberculosis susceptibility. | Qu HQ et al. | โ | 2011 | โ |
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| Long intergenic noncoding RNAs: new links in cancer progression. | Tsai MC et al. | โ | 2011 | โ |
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| Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms. | Pham MH et al. | โ | 2011 | โ |
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| Overview of the development of personalized genomic medicine and surgery. | Brunicardi FC et al. | โ | 2011 | โ |
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| Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. | So HC et al. | โ | 2011 | โ |
| Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci. | Meschia JF et al. | โ | 2011 | โ |
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| The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. | McCarty CA et al. | โ | 2011 | โ |
| The emerging role for rat models in gene discovery. | Dwinell MR et al. | โ | 2011 | โ |
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| Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery. | Emiroglu O et al. | โ | 2011 | โ |
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| Understanding the contribution of synonymous mutations to human disease. | Sauna ZE et al. | โ | 2011 | โ |
| Vaccinomics: current findings, challenges and novel approaches for vaccine development. | Ovsyannikova IG et al. | โ | 2011 | โ |
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| What did we learn from the genome-wide association study for tuberculosis susceptibility? | Qu HQ et al. | โ | 2011 | โ |
| World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: part 2. | Bloomgarden ZT | โ | 2011 | โ |
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| A genome-wide association study of amygdala activation in youths with and without bipolar disorder. | Liu X et al. | โ | 2010 | โ |
| A knowledge-based weighting framework to boost the power of genome-wide association studies. | Li MX et al. | โ | 2010 | โ |
| Analysing biological pathways in genome-wide association studies. | Wang K et al. | โ | 2010 | โ |
| Analyze multivariate phenotypes in genetic association studies by combining univariate association tests. | Yang Q et al. | โ | 2010 | โ |
| Analyzing complex traits with congenic strains. | Shao H et al. | โ | 2010 | โ |
| An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. | Patel CJ et al. | โ | 2010 | โ |
| Anonymization of electronic medical records for validating genome-wide association studies. | Loukides G et al. | โ | 2010 | โ |
| Assessment of improved prediction beyond traditional risk factors: when does a difference make a difference? | Janssens AC et al. | โ | 2010 | โ |
| A statistical method for scanning the genome for regions with rare disease alleles. | Garner C | โ | 2010 | โ |
| Asthma-susceptibility variants identified using probands in case-control and family-based analyses. | Himes BE et al. | โ | 2010 | โ |
| Being more realistic about the public health impact of genomic medicine. | Hall WD et al. | โ | 2010 | โ |
| Bioinformatics challenges for genome-wide association studies. | Moore JH et al. | โ | 2010 | โ |
| Breast cancer in the personal genomics era. | Ellsworth RE et al. | โ | 2010 | โ |
| Child and adolescent psychiatric genetics. | Hebebrand J et al. | โ | 2010 | โ |
| Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. | Cunnington MS et al. | โ | 2010 | โ |
| CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies. | Johnson AD et al. | โ | 2010 | โ |
| Common predisposition alleles for moderately common cancers: bladder cancer. | Kiltie AE | โ | 2010 | โ |
| Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth. | Liu G et al. | โ | 2010 | โ |
| Conference Scene: The great debate: genome-wide association studies in pharmacogenetics research, good or bad? | Bailey KR et al. | โ | 2010 | โ |
| Consumers' views of direct-to-consumer genetic information. | McBride CM et al. | โ | 2010 | โ |
| Copy number variation in Tourette syndrome: another case of neurodevelopmental generalist genes? | Scharf JM et al. | โ | 2010 | โ |
| Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures. | Salem RM et al. | โ | 2010 | โ |
| DataSHIELD: resolving a conflict in contemporary bioscience--performing a pooled analysis of individual-level data without sharing the data. | Wolfson M et al. | โ | 2010 | โ |
| Deciphering the molecular basis of venous thromboembolism: where are we and where should we go? | Morange PE et al. | โ | 2010 | โ |
| Direct-to-Consumer Genetic and Genomic Testing: Preparing Nurse Practitioners for Genomic Healthcare. | Loud JT | โ | 2010 | โ |
| Direct-to-consumer marketing of genetic and genomic tests. | Oncology Nursing Society | โ | 2010 | โ |
| Do alterations in mitochondrial DNA play a role in breast carcinogenesis? | Rohan TE et al. | โ | 2010 | โ |
| Efficient evaluation of ranking procedures when the number of units is large, with application to SNP identification. | Louis TA et al. | โ | 2010 | โ |
| Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies. | So HC et al. | โ | 2010 | โ |
| Evaluating the transferability of Hapmap SNPs to a Singapore Chinese population. | Andiappan AK et al. | โ | 2010 | โ |
| Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. | Elliott KS et al. | โ | 2010 | โ |
| Evaluation of genetic tests for susceptibility to common complex diseases: why, when and how? | Wright CF et al. | โ | 2010 | โ |
| Explaining inter-individual variability in phenotype: is epigenetics up to the challenge? | Turan N et al. | โ | 2010 | โ |
| Exploring genetic susceptibility to cancer in diverse populations. | Haiman CA et al. | โ | 2010 | โ |
| Family-based genetic risk prediction of multifactorial disease. | Ruderfer DM et al. | โ | 2010 | โ |
| FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. | Cattaert T et al. | โ | 2010 | โ |
| From GWAS to the clinic: risk factors for intracranial aneurysms. | Ruigrok YM et al. | โ | 2010 | โ |
| Future health applications of genomics: priorities for communication, behavioral, and social sciences research. | McBride CM et al. | โ | 2010 | โ |
| Gene copy number variation and common human disease. | Fanciulli M et al. | โ | 2010 | โ |
| "Genes to society"--the logic and process of the new curriculum for the Johns Hopkins University School of Medicine. | Wiener CM et al. | โ | 2010 | โ |
| Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. | Yang Z et al. | โ | 2010 | โ |
| Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q. | Fenstad MH et al. | โ | 2010 | โ |
| Genetic mapping and positional cloning. | Aitman TJ et al. | โ | 2010 | โ |
| Genetics for the practicing dermatologist. | Feramisco JD et al. | โ | 2010 | โ |
| Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation. | Winkler CA et al. | โ | 2010 | โ |
| Genetics of psychiatric disorders methods: molecular approaches. | Avramopoulos D | โ | 2010 | โ |
| Genetic variation of DKK3 may modify renal disease severity in ADPKD. | Liu M et al. | โ | 2010 | โ |
| Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. | Athanasiu L et al. | โ | 2010 | โ |
| Genome-scale approaches to the epigenetics of common human disease. | Feinberg AP | โ | 2010 | โ |
| Genomewide association studies and assessment of the risk of disease. | Manolio TA | โ | 2010 | โ |
| Genome-wide association studies and genetic risk assessment of liver diseases. | Krawczyk M et al. | โ | 2010 | โ |
| Genome-wide association studies in cancer--current and future directions. | Chung CC et al. | โ | 2010 | โ |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | โ | 2010 | โ |
| Genome-wide association studies in nephrology research. | Kรถttgen A | โ | 2010 | โ |
| Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses. | Orr N et al. | โ | 2010 | โ |
| Genomic medicine--an updated primer. | Feero WG et al. | โ | 2010 | โ |
| Genomics of long-range regulatory elements. | Noonan JP et al. | โ | 2010 | โ |
| Genotype-based risk and pharmacogenetic sampling in clinical trials. | Schork NJ et al. | โ | 2010 | โ |
| Human behavioral informatics in genetic studies of neuropsychiatric disease: multivariate profile-based analysis. | Bloss CS et al. | โ | 2010 | โ |
| Human genetics of diabetic retinopathy: current perspectives. | Ng DP | โ | 2010 | โ |
| Human genome diversity: frequently asked questions. | Barbujani G et al. | โ | 2010 | โ |
| Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. | Drmanac R et al. | โ | 2010 | โ |
| Human population genetic diversity as a function of SNP type from HapMap data. | Garte S | โ | 2010 | โ |
| Individualized medicine 2010. | Blum HE | โ | 2010 | โ |
| Influence of microbial environment on autoimmunity. | Chervonsky AV | โ | 2010 | โ |
| Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data. | Chen LS et al. | โ | 2010 | โ |
| Interpretation of association signals and identification of causal variants from genome-wide association studies. | Wang K et al. | โ | 2010 | โ |
| Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. | Weissglas-Volkov D et al. | โ | 2010 | โ |
| Laboratory mouse models for the human genome-wide associations. | Kitsios GD et al. | โ | 2010 | โ |
| Leveraging informatics for genetic studies: use of the electronic medical record to enable a genome-wide association study of peripheral arterial disease. | Kullo IJ et al. | โ | 2010 | โ |
| Lost in the space of bioinformatic tools: a constantly updated survival guide for genetic epidemiology. The GenEpi Toolbox. | Coassin S et al. | โ | 2010 | โ |
| Macrophages, inflammation, and insulin resistance. | Olefsky JM et al. | โ | 2010 | โ |
| Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. | McMahon FJ et al. | โ | 2010 | โ |
| Methodological challenges of genome-wide association analysis in Africa. | Teo YY et al. | โ | 2010 | โ |
| MicroRNAs: Potential biomarkers in cancer. | George GP et al. | โ | 2010 | โ |
| Molecular diagnostics in transplantation. | Naesens M et al. | โ | 2010 | โ |
| Multi-marker tagging single nucleotide polymorphism selection using estimation of distribution algorithms. | Santana R et al. | โ | 2010 | โ |
| Neural markers of genetic vulnerability to drug addiction. | Mรผller DJ et al. | โ | 2010 | โ |
| Novel therapies in childhood heart failure: today and tomorrow. | Penny DJ et al. | โ | 2010 | โ |
| Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions. | Eastwood PR et al. | โ | 2010 | โ |
| Overview of personalized medicine in the disease genomic era. | Hong KW et al. | โ | 2010 | โ |
| Patterns of linkage disequilibrium in different populations: implications and opportunities for lipid-associated loci identified from genome-wide association studies. | Teo YY et al. | โ | 2010 | โ |
| Performance of common genetic variants in breast-cancer risk models. | Wacholder S et al. | โ | 2010 | โ |
| Pioneering first steps and cautious conclusions. | McMahon FJ | โ | 2010 | โ |
| Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya. | Zhang L et al. | โ | 2010 | โ |
| Power analysis for case-control association studies of samples with known family histories. | Peng B et al. | โ | 2010 | โ |
| Quality control and quality assurance in genotypic data for genome-wide association studies. | Laurie CC et al. | โ | 2010 | โ |
| Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. | Fortier I et al. | โ | 2010 | โ |
| Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape. | Young NM et al. | โ | 2010 | โ |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | โ | 2010 | โ |
| Screening of Kozak-motif-located SNPs and analysis of their association with human diseases. | Xu H et al. | โ | 2010 | โ |
| SNPTransformer: a lightweight toolkit for genome-wide association studies. | Dong C | โ | 2010 | โ |
| Statistical analysis strategies for association studies involving rare variants. | Bansal V et al. | โ | 2010 | โ |
| Statistical methods for pathway analysis of genome-wide data for association with complex genetic traits. | Holmans P | โ | 2010 | โ |
| Statistical significance in genetic association studies. | Qu HQ et al. | โ | 2010 | โ |
| The behavioral response to personalized genetic information: will genetic risk profiles motivate individuals and families to choose more healthful behaviors? | McBride CM et al. | โ | 2010 | โ |
| The DARC side of GWAS. | Chanock SJ | โ | 2010 | โ |
| The genetic basis of spondyloarthritis: SPARTAN/IGAS 2009. | Evans DM et al. | โ | 2010 | โ |
| The genetics of ischaemic stroke. | Matarin M et al. | โ | 2010 | โ |
| The molecular pathology of cancer. | Harris TJ et al. | โ | 2010 | โ |
| Two-stage case-control designs for rare genetic variants. | Schaid DJ et al. | โ | 2010 | โ |
| Uncovering the roles of rare variants in common disease through whole-genome sequencing. | Cirulli ET et al. | โ | 2010 | โ |
| Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies. | Crossett A et al. | โ | 2010 | โ |
| Using genetics to predict the natural history of asthma? | Holloway JW et al. | โ | 2010 | โ |
| Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population. | Nanfang L et al. | โ | 2010 | โ |
| Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies. | Yoo YJ et al. | โ | 2010 | โ |
| What role for genetics in the prediction of multiple sclerosis? | Sawcer S et al. | โ | 2010 | โ |
| Advanced gastric cancer: is laparoscopic gastrectomy safe? | Liakakos T et al. | โ | 2009 | โ |
| A framework for interpreting genome-wide association studies of psychiatric disorders. | Psychiatric GWAS Consortium Steering Committee | โ | 2009 | โ |
| A genome wide survey of SNP variation reveals the genetic structure of sheep breeds. | Kijas JW et al. | โ | 2009 | โ |
| A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies. | Jacobs KB et al. | โ | 2009 | โ |
| An open access database of genome-wide association results. | Johnson AD et al. | โ | 2009 | โ |
| Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? | Cook SA et al. | โ | 2009 | โ |
| Assessing both genetic variation (SNPs/CNVs) and gene-environment interactions may lead to personalized gastric cancer prevention. | Roukos DH | โ | 2009 | โ |
| Beyond odds ratios--communicating disease risk based on genetic profiles. | Kraft P et al. | โ | 2009 | โ |
| Beyond proof of principle: new genes for Alzheimer's disease through collaboration. | Pericak-Vance MA et al. | โ | 2009 | โ |
| Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection. | Barker PE et al. | โ | 2009 | โ |
| Building a knowledge base on genetic variation and cancer risk through field synopses. | Yesupriya A et al. | โ | 2009 | โ |
| Challenges in developing robust genetic markers and targets to predict and prevent distant and peritoneal recurrence in gastric cancer. | Ziogas D et al. | โ | 2009 | โ |
| Circulating cancer cells: could they be used in the clinic as recurrence markers for gastric and colorectal cancer? | Hanisch E et al. | โ | 2009 | โ |
| Cis-regulatory mutations in human disease. | Epstein DJ | โ | 2009 | โ |
| Cohort studies and the genetics of complex disease. | Manolio TA | โ | 2009 | โ |
| Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics. | Manolio TA | โ | 2009 | โ |
| Common genetic variants in sudden cardiac death. | George AL | โ | 2009 | โ |
| Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population. | Wang M et al. | โ | 2009 | โ |
| Common genetic variation and human traits. | Goldstein DB | โ | 2009 | โ |
| Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. | International Schizophrenia Consortium et al. | โ | 2009 | โ |
| Common variants at 30 loci contribute to polygenic dyslipidemia. | Kathiresan S et al. | โ | 2009 | โ |
| Common variants at ten loci modulate the QT interval duration in the QTSCD Study. | Pfeufer A et al. | โ | 2009 | โ |
| Common variants on chromosome 6p22.1 are associated with schizophrenia. | Shi J et al. | โ | 2009 | โ |
| Common vs. rare allele hypotheses for complex diseases. | Schork NJ et al. | โ | 2009 | โ |
| Complex diseases, complex genes: keeping pathways on the right track. | Kraft P et al. | โ | 2009 | โ |
| Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer. | Yeager M et al. | โ | 2009 | โ |
| Control of fetal hemoglobin: new insights emerging from genomics and clinical implications. | Thein SL et al. | โ | 2009 | โ |
| Control selection options for genome-wide association studies in cohorts. | Wacholder S et al. | โ | 2009 | โ |
| Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. | Spencer CC et al. | โ | 2009 | โ |
| Detecting shared pathogenesis from the shared genetics of immune-related diseases. | Zhernakova A et al. | โ | 2009 | โ |
| Discovering novel risk factors for venous thrombosis: a candidate-gene approach. | Smith NL et al. | โ | 2009 | โ |
| Discovery of rare variants via sequencing: implications for the design of complex trait association studies. | Li B et al. | โ | 2009 | โ |
| Dissecting the phenotype in genome-wide association studies of psychiatric illness. | Cross-Disorder Phenotype Group of the Psychiatric GWAS Consortium et al. | โ | 2009 | โ |
| Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies. | Bacolod MD et al. | โ | 2009 | โ |
| Epigenetics in gastric cancer: challenges for clinical implications. | Ziogas D et al. | โ | 2009 | โ |
| Ethical data release in genome-wide association studies in developing countries. | Parker M et al. | โ | 2009 | โ |
| Evaluation of risk prediction updates from commercial genome-wide scans. | Mihaescu R et al. | โ | 2009 | โ |
| Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. | Lou H et al. | โ | 2009 | โ |
| Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. | Holmans P et al. | โ | 2009 | โ |
| Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment. | Li Q et al. | โ | 2009 | โ |
| Genetic risk prediction--are we there yet? | Kraft P et al. | โ | 2009 | โ |
| Genetics and genomics of chronic obstructive pulmonary disease. | Silverman EK et al. | โ | 2009 | โ |
| Genetics and personal genomics for personalized breast cancer surgery: progress and challenges in research and clinical practice. | Ziogas D et al. | โ | 2009 | โ |
| Genetics and the general physician: insights, applications and future challenges. | Knight JC | โ | 2009 | โ |
| Genetic scoring analysis: a way forward in genome wide association studies? | Amin N et al. | โ | 2009 | โ |
| Genetics of bipolar disorder: successful start to a long journey. | Craddock N et al. | โ | 2009 | โ |
| Genetic susceptibility in Parkinson's disease. | Bras JM et al. | โ | 2009 | โ |
| Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. | Vasan RS et al. | โ | 2009 | โ |
| Genetic variation in the hypothalamic pathways and its role on obesity. | van Vliet-Ostaptchouk JV et al. | โ | 2009 | โ |
| Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. | Moskvina V et al. | โ | 2009 | โ |
| Genome-based prediction of common diseases: methodological considerations for future research. | Janssens AC et al. | โ | 2009 | โ |
| Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. | Himes BE et al. | โ | 2009 | โ |
| Genome-wide association database developed in the Japanese Integrated Database Project. | Koike A et al. | โ | 2009 | โ |
| Genome-wide association studies and aggressive surgery toward individualized prevention, and improved local control and overall survival for gastric cancer. | Roukos DH | โ | 2009 | โ |
| Genomewide association studies and human disease. | Hardy J et al. | โ | 2009 | โ |
| Genome-wide association studies--a summary for the clinical gastroenterologist. | Melum E et al. | โ | 2009 | โ |
| Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. | Khoury MJ et al. | โ | 2009 | โ |
| Genome-wide association studies for atherosclerotic vascular disease and its risk factors. | Ding K et al. | โ | 2009 | โ |
| Genomewide association studies: history, rationale, and prospects for psychiatric disorders. | Psychiatric GWAS Consortium Coordinating Committee et al. | โ | 2009 | โ |
| Genome-wide association studies: hypothesis-"free" or "engaged"? | Kitsios GD et al. | โ | 2009 | โ |
| Genome-wide association studies in ADHD. | Franke B et al. | โ | 2009 | โ |
| Genome-wide association studies in bladder cancer: first results and potential relevance. | Kiemeney LA et al. | โ | 2009 | โ |
| Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. | Knauff EA et al. | โ | 2009 | โ |
| Genome-wide association study of bipolar disorder in European American and African American individuals. | Smith EN et al. | โ | 2009 | โ |
| Genome-wide association study of blood pressure and hypertension. | Levy D et al. | โ | 2009 | โ |
| Genome-wide association study of smoking initiation and current smoking. | Vink JM et al. | โ | 2009 | โ |
| Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. | Holmans PA et al. | โ | 2009 | โ |
| Genomic analysis of left ventricular remodeling. | Sarwar R et al. | โ | 2009 | โ |
| Genomic and personalized medicine: foundations and applications. | Ginsburg GS et al. | โ | 2009 | โ |
| High marks for GWAS. | Chanock S | โ | 2009 | โ |
| Hypothesis-driven candidate gene association studies: practical design and analytical considerations. | Jorgensen TJ et al. | โ | 2009 | โ |
| Identifying susceptibility genes of IgA nephropathy: research in progress. | Barua M et al. | โ | 2009 | โ |
| Imaging phenotypes of major depressive disorder: genetic correlates. | Savitz JB et al. | โ | 2009 | โ |
| Information management to enable personalized medicine: stakeholder roles in building clinical decision support. | Downing GJ et al. | โ | 2009 | โ |
| Integrating genomics across drug discovery and development. | Debouck C | โ | 2009 | โ |
| Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. | Khoury MJ et al. | โ | 2009 | โ |
| Invited commentary: maternal effects in preterm birth--effects of maternal genotype, mitochondrial DNA, imprinting, or environment? | Little J | โ | 2009 | โ |
| Is there still a need for candidate gene approaches in the era of genome-wide association studies? | Wilkening S et al. | โ | 2009 | โ |
| Laparoscopic colectomy survival benefit for colon cancer: is evidence from a randomized trial true? | Ziogas D et al. | โ | 2009 | โ |
| Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. | Evangelou E et al. | โ | 2009 | โ |
| LD-spline: mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium. | Bush WS et al. | โ | 2009 | โ |
| MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. | Xiong L et al. | โ | 2009 | โ |
| Meta-analysis in genome-wide association studies. | Zeggini E et al. | โ | 2009 | โ |
| Meta-analysis of 32 genome-wide linkage studies of schizophrenia. | Ng MY et al. | โ | 2009 | โ |
| Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. | Nakaoka H et al. | โ | 2009 | โ |
| MicroRNA polymorphisms: a giant leap towards personalized medicine. | Mishra PJ | โ | 2009 | โ |
| MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine. | Mishra PJ et al. | โ | 2009 | โ |
| Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans. | Silverman GA et al. | โ | 2009 | โ |
| Neoadjuvant chemotherapy for breast cancer: does pretreatment axillary nodal staging improve decision making? | Batsis C et al. | โ | 2009 | โ |
| New findings from genetic association studies of schizophrenia. | Williams HJ et al. | โ | 2009 | โ |
| Novel mutations of ABCC6 gene in Japanese patients with Angioid streaks. | Sato N et al. | โ | 2009 | โ |
| Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. | Eleftherohorinou H et al. | โ | 2009 | โ |
| Personal genomics and genome-wide association studies: novel discoveries but limitations for practical personalized medicine. | Roukos DH | โ | 2009 | โ |
| Personalized genetic prediction: too limited, too expensive, or too soon? | Ioannidis JP | โ | 2009 | โ |
| Personalized medicine: a transformative approach is needed. | Hudson TJ | โ | 2009 | โ |
| Platelet genomics beats the catch-22. | Bray PF | โ | 2009 | โ |
| Policy perspectives on the emerging pathways of personalized medicine. | Downing GJ | โ | 2009 | โ |
| Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. | Hindorff LA et al. | โ | 2009 | โ |
| Predicting response to short-acting bronchodilator medication using Bayesian networks. | Himes BE et al. | โ | 2009 | โ |
| Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers. | Ioannidis JP | โ | 2009 | โ |
| Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses. | Craddock N et al. | โ | 2009 | โ |
| Recent advances in genetic predisposition to clinical acute lung injury. | Gao L et al. | โ | 2009 | โ |
| Repertoires of the nucleosome-positioning dinucleotides. | Bettecken T et al. | โ | 2009 | โ |
| Replication in genome-wide association studies. | Kraft P et al. | โ | 2009 | โ |
| Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification. | Ioannidis JP et al. | โ | 2009 | โ |
| Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. | Dick DM et al. | โ | 2009 | โ |
| Schizophrenia genetics: advancing on two fronts. | Owen MJ et al. | โ | 2009 | โ |
| Schizophrenia genetics: new insights from new approaches. | Williams HJ et al. | โ | 2009 | โ |
| Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 2: Personalised nutrition. Genetic variation and disease risk: new advances. | Scott J | โ | 2009 | โ |
| Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae. | Kenny EE et al. | โ | 2009 | โ |
| Systems-based candidate genes for human response to influenza infection. | Zhang L et al. | โ | 2009 | โ |
| Systems pharmacology and genome medicine: a future perspective. | Wist AD et al. | โ | 2009 | โ |
| The A's, G's, C's, and T's of health disparities. | Ramos E et al. | โ | 2009 | โ |
| The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. | Biesecker LG et al. | โ | 2009 | โ |
| The genetic signatures of noncoding RNAs. | Mattick JS | โ | 2009 | โ |
| The genetics of reading disability. | Petryshen TL et al. | โ | 2009 | โ |
| The genetics of Tourette syndrome: a review. | O'Rourke JA et al. | โ | 2009 | โ |
| The genomic applications in practice and prevention network. | Khoury MJ et al. | โ | 2009 | โ |
| The HapMap and genome-wide association studies in diagnosis and therapy. | Manolio TA et al. | โ | 2009 | โ |
| The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. | Khoury MJ et al. | โ | 2009 | โ |
| The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects. | Molloy AM et al. | โ | 2009 | โ |
| The year in atherothrombosis. | Sanz J et al. | โ | 2009 | โ |
| Transgenerational genetic effects on phenotypic variation and disease risk. | Nadeau JH | โ | 2009 | โ |
| Underlying genetic models of inheritance in established type 2 diabetes associations. | Salanti G et al. | โ | 2009 | โ |
| Validating, augmenting and refining genome-wide association signals. | Ioannidis JP et al. | โ | 2009 | โ |
| Visualization of shared genomic regions and meiotic recombination in high-density SNP data. | Roberson ED et al. | โ | 2009 | โ |
| Why is epidemiology necessary to policy-making? | Vineis P et al. | โ | 2009 | โ |
| Cardiovascular genomics, personalized medicine, and the National Heart, Lung, and Blood Institute: part I: the beginning of an era. | O'Donnell CJ et al. | โ | 2008 | โ |
| Common genetic variation and human disease. | Orr N et al. | โ | 2008 | โ |
| Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers. | Yeager M et al. | โ | 2008 | โ |
| Curses--winner's and otherwise--in genetic epidemiology. | Kraft P | โ | 2008 | โ |
| Developmental biology. From genetic association to genetic switch. | Michelson AM | โ | 2008 | โ |
| From Darwin's finches to canaries in the coal mine--mining the genome for new biology. | Hunter DJ et al. | โ | 2008 | โ |
| Gene-gene interactions in the NOD mouse model of type 1 diabetes. | Ridgway WM et al. | โ | 2008 | โ |
| Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases. | Yu W et al. | โ | 2008 | โ |
| Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. | Shao H et al. | โ | 2008 | โ |
| Genome-based prediction of common diseases: advances and prospects. | Janssens AC et al. | โ | 2008 | โ |
| Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. | Sankaran VG et al. | โ | 2008 | โ |
| Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer. | Wacholder S et al. | โ | 2008 | โ |
| Is the time right for translation research in genomics? | Janssens AC | โ | 2008 | โ |
| Management of High-Throughput DNA Sequencing Projects: Alpheus. | Miller NA et al. | โ | 2008 | โ |
| MicroRNA target site polymorphisms and human disease. | Sethupathy P et al. | โ | 2008 | โ |
| Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases. | Steinlein OK et al. | โ | 2008 | โ |
| Obesity genes: so close and yet so far... | Pomp D et al. | โ | 2008 | โ |
| Potential of nutrigenetics in the treatment of metabolic disorders. | Wood PA | โ | 2008 | โ |
| Progress and challenges in genome-wide association studies in humans. | Donnelly P | โ | 2008 | โ |
| Promoting regulatory gene variation in sodium reabsorption. | Doris PA | โ | 2008 | โ |
| Public health genomics approach to type 2 diabetes. | Khoury MJ et al. | โ | 2008 | โ |
| Quantitative genetics of renal function: tackling complexities of the eGFR phenotype in gene mapping studies. | Kiryluk K | โ | 2008 | โ |
| Role of MicroRNA in pancreatic beta-cells: where more is less. | Walker MD | โ | 2008 | โ |
| Shedding light on skin cancer. | Pharoah PD | โ | 2008 | โ |
| Statistical issues in the analysis of DNA Copy Number Variations. | Wineinger NE et al. | โ | 2008 | โ |
| Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. | Weiss KM | โ | 2008 | โ |
| Update in endocrine autoimmunity. | Anderson MS | โ | 2008 | โ |