Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism.
paper
Cited
Public
Unavailable
- Authors
- Klyosov, A A; Rashkovetsky, L G; Tahir, M K; Keung, W M
- Year
- 1996
- Journal
- Biochemistry
- PMID
- 8605194
- DOI
- 10.1021/bi9521093
To provide a molecular basis for understanding the possible mechanism of action of antidipsotropic agents in laboratory animals, aldehyde dehydrogenase (ALDH) isozymes were purified and characterized from the livers of hamsters and rats and compared with those from humans. The mitochondrial ALDHs from these species exhibit virtually identical kinetic properties in the oxidation and hydrolysis reactions. However, the cytosolic ALDH of human origin differs significantly from those of the rodents. Thus, for human ALDH-1, the Km value for acetaldehyde is 180 +/- 10 micromolar, whereas those for hamster ALDH-1 and rat ALDH-1 are 12 +/- 3 and 15 +/- 3 micromolar, respectively. Km values determined at pH 9.5 are virtually identical to those measured at pH 7.5. In vitro human ALDH-1 is 10 times less sensitive to disulfiram inhibition than are the hamster and rat cytosolic ALDHs. Competition between acetaldehyde and aromatic aldehydes or naphthaldehydes for the binding and catalytic sites of ALDHs shows their topography to be complex with more than one binding site. This also follows from data on substrate inhibition and activation, effects of NAD+ on ALDH-catalyzed hydrolysis of p-nitrophenyl esters, substrate specificity toward aldehydes and p-nitrophenyl esters, and inhibition by disulfiram in relation to oxidation and hydrolysis catalyzed by the ALDHs. The data further suggest that acetaldehyde cannot be considered as a "standard" ALDH substrate for studies aimed at aromatic ALDH substrates, e.g. biogenic aldehydes. Apparently, in human liver, only mitochondrial ALDH oxidizes acetaldehyde at physiological concentrations, whereas in hamster or rat liver, both the mitochondrial and cytosolic isozymes will do so.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genes encoding enzymes involved in ethanol metabolism. | 2012 | 23134050 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Challenges, optimization, and delivery strategies in the heterologous expression of aldehyde dehydrogenase: therapeutic applications for acetaldehyde detoxification. | Qiao S et al. | β | 2026 | β |
| ALDH2 Deficiency and Alcohol Intake in the United States: Opportunity for Precision Cancer Prevention. | Forman D et al. | β | 2025 | β |
| ALDH2 plays a role in spermatogenesis and male fertility by regulating oxidative stress in mice. | Lv Y et al. | β | 2025 | β |
| cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression. | Wang Y et al. | β | 2025 | β |
| Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone. | Sato R et al. | β | 2025 | β |
| Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. | Stem AD et al. | β | 2025 | β |
| 4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal Cell Death for Lifestyle-Related Diseases. | Yamashima T | β | 2024 | β |
| Aldehyde Dehydrogenase 2 (ALDH2): A novel sorafenib target in hepatocellular carcinoma unraveled by the proteome-wide cellular thermal shift assay. | Ferreira IC et al. | β | 2024 | β |
| ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment. | Flashner S et al. | β | 2024 | β |
| ALDH2 polymorphism and myocardial infarction: From alcohol metabolism to redox regulation. | Lamb RJ et al. | β | 2024 | β |
| Endogenous ethanol production in health and disease. | Meijnikman AS et al. | β | 2024 | β |
| Enhancing Mycoprotein Yield: Metabolic Modulation of Chitin Synthase in <i>Fusarium venenatum</i>. | Hong R et al. | β | 2024 | β |
| Molecular targets of PXR-dependent ethanol-induced hepatotoxicity in female mice. | Choi S et al. | β | 2024 | β |
| Pharmacological activators of ALDH2: A new strategy for the treatment of alcohol use disorders. | Adasme-Reyes S et al. | β | 2024 | β |
| The biochemistry of the carcinogenic alcohol metabolite acetaldehyde. | Thomas LA et al. | β | 2024 | β |
| A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice. | Lee AS et al. | β | 2023 | β |
| A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators. | Chang YC et al. | β | 2023 | β |
| Alcohol and breast cancer. | Starek-Εwiechowicz B et al. | β | 2023 | β |
| Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia-Reperfusion Injury by Suppressing the I<i>ΞΊ</i>B<i>Ξ±</i>/NF-<i>ΞΊ</i>B/IL-17C Pathway. | Chen Y et al. | β | 2023 | β |
| Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy. | Karan BM et al. | β | 2023 | β |
| Gene Therapy to Treat Osteopenia Associated With Chronic Ethanol Consumption and Aldehyde Dehydrogenase 2 Deficiency. | Camilleri AE et al. | β | 2023 | β |
| Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer. | Xanthis V et al. | β | 2023 | β |
| Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease. | Seike T et al. | β | 2023 | β |
| Alcohol Consumption, <i>ALDH2</i> Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and Prognosis. | Chen CH et al. | β | 2022 | β |
| Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. | Montel RA et al. | β | 2022 | β |
| E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme. | Yu X et al. | β | 2022 | β |
| Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury. | Rungratanawanich W et al. | β | 2021 | β |
| Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice. | Yang SS et al. | β | 2021 | β |
| ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis. | Hu YF et al. | β | 2021 | β |
| A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. | Li J et al. | β | 2021 | β |
| E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme | Yu X et al. | β | 2021 | β |
| Evaluation of spice and herb as phyto-derived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method. | Bui TBC et al. | β | 2021 | β |
| <i>Primum Non Nocere:</i> Should Gene Therapy Be Used to Prevent Potentially Fatal Disease but Enable Potentially Destructive Behavior? | de Melo-Martin I et al. | β | 2021 | β |
| Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis. | Johnson CH et al. | β | 2021 | β |
| Pancreatic cancer: A review of epidemiology, trend, and risk factors. | Hu JX et al. | β | 2021 | β |
| Apoferritin as a Carrier of Cu(II) Diethyldithiocarbamate and Biomedical Application for Glutathione-Responsive Combination Chemotherapy. | Li X et al. | β | 2020 | β |
| Comprehensive analysis on phenotype and genetic basis of Chinese Fanconi anemia patients: dismal outcomes call for nationwide studies. | Nie D et al. | β | 2020 | β |
| Impact of alcohol drinking on cancer risk with consideration of flushing response: The Japan Public Health Center-based Prospective Study Cohort (JPHC study). | Ono A et al. | β | 2020 | β |
| Mitochondrially-targeted treatment strategies. | Bozi LHM et al. | β | 2020 | β |
| Risk Factors and Genetic Biomarkers of Multiple Primary Cancers in Esophageal Cancer Patients. | Yang PW et al. | β | 2020 | β |
| Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion. | Matsumura Y et al. | β | 2020 | β |
| Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism? | Rivera-Meza M et al. | β | 2019 | β |
| Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation. | Serio RN et al. | β | 2019 | β |
| Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency. | Matsumura Y et al. | β | 2019 | β |
| Impaired dopamine metabolism in Parkinson's disease pathogenesis. | Masato A et al. | β | 2019 | β |
| Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia. | Kinoshita K et al. | β | 2019 | β |
| Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. | Shabtai Y et al. | β | 2018 | β |
| Could ALDH2<sup>*</sup>2 be the reason for low incidence and mortality of ovarian cancer for East Asia women? | Yan S et al. | β | 2018 | β |
| Effects of ethanol on the anticancer function of doxorubicin in JJ012 cells. | Huang H et al. | β | 2018 | β |
| Fanconi anaemia and cancer: an intricate relationship. | Nalepa G et al. | β | 2018 | β |
| Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice. | Choi S et al. | β | 2018 | β |
| Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update. | Panisello-RosellΓ³ A et al. | β | 2018 | β |
| Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. | Lusk R et al. | β | 2018 | β |
| ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective. | Chang JS et al. | β | 2017 | β |
| A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture. | Takeshima K et al. | β | 2017 | β |
| Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives. | Buchman CD et al. | β | 2017 | β |
| Mitochondria and Angiogenesis. | Marcu R et al. | β | 2017 | β |
| Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances. | Abdelmegeed MA et al. | β | 2017 | β |
| Synergistic Interaction of Light Alcohol Administration in the Presence of Mild Iron Overload in a Mouse Model of Liver Injury: Involvement of Triosephosphate Isomerase Nitration and Inactivation. | Gao W et al. | β | 2017 | β |
| Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. | Chen Y et al. | β | 2016 | β |
| Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD<sup>+</sup> and retinoic acid. | Moretti A et al. | β | 2016 | β |
| De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility. | Kawai T et al. | β | 2016 | β |
| Estrogen receptor ERΞ± plays a major role in ethanol-evoked myocardial oxidative stress and dysfunction in conscious female rats. | Yao F et al. | β | 2016 | β |
| Ethanol-metabolizing activities and isozyme protein contents of alcohol and aldehyde dehydrogenases in human liver: phenotypic traits of the ADH1B*2 and ALDH2*2 variant gene alleles. | Chiang CP et al. | β | 2016 | β |
| Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. | Sapag A et al. | β | 2016 | β |
| (13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo. | Dzien P et al. | β | 2015 | β |
| Acute and chronic ethanol exposure differentially alters alcohol dehydrogenase and aldehyde dehydrogenase activity in the zebrafish liver. | Tran S et al. | β | 2015 | β |
| Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. | Morgan CA et al. | β | 2015 | β |
| Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. | Buchman CD et al. | β | 2015 | β |
| Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases. | Zhao Y et al. | β | 2015 | β |
| Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease? - A mechanistic hypothesis. | de Medeiros IC et al. | β | 2015 | β |
| Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium. | Amanuma Y et al. | β | 2015 | β |
| Steady-state metabolism of ethanol in perfused rat livers treated with cyanamide: quantitative analysis of acetaldehyde effects on the metabolic flux rates. | Yao CT et al. | β | 2015 | β |
| Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease. | Song BJ et al. | β | 2015 | β |
| Maternal aldehyde elimination during pregnancy preserves the fetal genome. | Oberbeck N et al. | β | 2014 | β |
| Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. | Chen CH et al. | β | 2014 | β |
| Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. | Singh S et al. | β | 2013 | β |
| Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2. | Jackson BC et al. | β | 2013 | β |
| Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice. | Tsuchiya T et al. | β | 2013 | β |
| Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. | Shalbueva N et al. | β | 2013 | β |
| Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease. | Song BJ et al. | β | 2013 | β |
| Ocular aldehyde dehydrogenases: protection against ultraviolet damage and maintenance of transparency for vision. | Chen Y et al. | β | 2013 | β |
| Potent inhibition of aldehyde dehydrogenase-2 by diphenyleneiodonium: focus on nitroglycerin bioactivation. | Neubauer R et al. | β | 2013 | β |
| Protective effect of Aplysin on hepatic injury in ethanol-treated rats. | Ge N et al. | β | 2013 | β |
| A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in rat. | Kiwamoto R et al. | β | 2012 | β |
| Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary. | Kawai T et al. | β | 2012 | β |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | β | 2012 | β |
| Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. | Hvenegaard MG et al. | β | 2012 | β |
| Nitroglycerin use in myocardial infarction patients. | Ferreira JC et al. | β | 2012 | β |
| Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. | Lang BS et al. | β | 2012 | β |
| Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with H-NMR based metabolic profiling. | Kim SH et al. | β | 2011 | β |
| Comparative study of the hepatoprotective efficacy of Artemisia iwayomogiβand Artemisia capillaris on ethanol-administered mice. | Lee HI et al. | β | 2011 | β |
| Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications. | Song BJ et al. | β | 2011 | β |
| Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. | Sobreira TJ et al. | β | 2011 | β |
| Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. | Stagos D et al. | β | 2010 | β |
| Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1. | Beretta M et al. | β | 2010 | β |
| Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. | Mittal P et al. | β | 2010 | β |
| Effects of chitooligosaccharide lactate salt on activity of acetaldehyde dehydrogenase. | Cho SY et al. | β | 2010 | β |
| Mitochondrial aldehyde dehydrogenase and cardiac diseases. | Chen CH et al. | β | 2010 | β |
| Pathogenesis of alcoholic liver disease: the role of nuclear receptors. | Gyamfi MA et al. | β | 2010 | β |
| Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. | Ren J et al. | β | 2009 | β |
| Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy"). | Upreti VV et al. | β | 2009 | β |
| Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. | Nagayoshi H et al. | β | 2009 | β |
| Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. | Sapag A et al. | β | 2009 | β |
| Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2. | Wenzl MV et al. | β | 2009 | β |
| The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. | Ginsberg G et al. | β | 2009 | β |
| Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases. | Beretta M et al. | β | 2008 | β |
| Fasciola gigantica: enzymes of the ornithine-proline-glutamate pathway--characterization of delta1-pyrroline-5-carboxylate dehydrogenase. | Mohamed SA et al. | β | 2008 | β |
| Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. | Marchitti SA et al. | β | 2008 | β |
| Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin. | Beretta M et al. | β | 2008 | β |
| Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues. | Kundu TK et al. | β | 2007 | β |
| Ethyl tertiary-butyl ether: a toxicological review. | McGregor D | β | 2007 | β |
| Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver. | Moon KH et al. | β | 2007 | β |
| Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk. | McGregor NR | β | 2007 | β |
| The biochemistry of drug metabolism--an introduction: Part 2. Redox reactions and their enzymes. | Testa B et al. | β | 2007 | β |
| Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. | Yoon M et al. | β | 2006 | β |
| Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. | Li Y et al. | β | 2006 | β |
| The role of retinoid X receptor alpha in regulating alcohol metabolism. | Gyamfi MA et al. | β | 2006 | β |
| Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations. | Rahman FB et al. | β | 2006 | β |
| Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. | Lassen N et al. | β | 2005 | β |
| Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence. | Keung WM | β | 2003 | β |
| Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. | Spence JP et al. | β | 2003 | β |
| Herbal remedies for alcoholism: promises and possible pitfalls. | Overstreet DH et al. | β | 2003 | β |
| Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact. | SlΓ‘dek NE | β | 2003 | β |
| Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats. | Sapag A et al. | β | 2003 | β |
| Plant derivatives in the treatment of alcohol dependency. | Rezvani AH et al. | β | 2003 | β |
| Purification and characterization of two distinct aldehyde-oxidizing enzymes from the liver of black seabream. | Fong WP et al. | β | 2003 | β |
| Use of an "acetaldehyde clamp" in the determination of low-KM aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells. | Moncada C et al. | β | 2003 | β |
| Characterization of the amino acids involved in substrate specificity of nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans. | Marchal S et al. | β | 2002 | β |
| First purification of the antiquitin protein and demonstration of its enzymatic activity. | Tang WK et al. | β | 2002 | β |
| Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: implications for risk assessment. | Ginsberg G et al. | β | 2002 | β |
| Biogenic aldehyde(s) derived from the action of monoamine oxidase may mediate the antidipsotropic effect of daidzin. | Keung WM | β | 2001 | β |
| Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol. | Garver E et al. | β | 2001 | β |
| Profiling the specific reactivity of the proteome with non-directed activity-based probes. | Adam GC et al. | β | 2001 | β |
| Purification and characterization of grass carp mitochondrial aldehyde dehydrogenase. | Fong W et al. | β | 2001 | β |
| Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. | Kitagawa K et al. | β | 2000 | β |
| De novo sequencing of proteolytic peptides by a combination of C-terminal derivatization and nano-electrospray/collision-induced dissociation mass spectrometry. | Lindh I et al. | β | 2000 | β |
| Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes. | Kathmann EC et al. | β | 2000 | β |
| Volitional ethanol consumption affects overall serotonin metabolism in Syrian golden hamsters (Mesocricetus auratus). | Keung WM et al. | β | 2000 | β |
| A structural explanation for the retinal specificity of class 1 ALDH enzymes. | Moore SA et al. | β | 1999 | β |
| Intralobular distribution of class I alcohol dehydrogenase and aldehyde dehydrogenase 2 activities in the hamster liver. | Watabiki T et al. | β | 1999 | β |
| Aldehyde dehydrogenase (CoA-acetylating) and the mechanism of ethanol formation in the amitochondriate protist, Giardia lamblia. | SΓ‘nchez LB | β | 1998 | β |
| Glyoxylate synthesis, and its modulation and influence on oxalate synthesis. | Holmes RP et al. | β | 1998 | β |
| Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram. | Mays DC et al. | β | 1998 | β |
| Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases. | Moore SA et al. | β | 1998 | β |
| The effect of ethanol and its metabolites upon methionine synthase activity in vitro. | Kenyon SH et al. | β | 1998 | β |
| Class 2 aldehyde dehydrogenase. Characterization of the hamster enzyme, sensitive to daidzin and conserved within the family of multiple forms. | Hjelmqvist L et al. | β | 1997 | β |
| Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. | Keung WM et al. | β | 1997 | β |
| Studies of the esterase activity of cytosolic aldehyde dehydrogenase with resorufin acetate as substrate. | Kitson TM et al. | β | 1997 | β |