APOE ε4 gene
Evidence from:
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all sources
Related entities (6)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| APOE ε4 | associated_with | alpha power | — | 1 |
| APOE ε4 | risk_factor_for | Alzheimer's disease | — | 1 |
| APOE ε4 | risk_factor_for | Alzheimer’s disease | — | 1 |
| APOE ε4 | risk_factor_for | Aβ production | — | 1 |
| APOE ε4 | risk_factor_for | late-onset Alzheimer’s disease | — | 1 |
| APOE ε4 | risk_factor_for | tau phosphorylation | — | 1 |
Mentioned in (27)
Papers in which this entity is mentioned.
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders. (2023)
- Epigenetics in Alzheimer's Disease. (2022)
- A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. (2021)
- Polygenic risk scores: from research tools to clinical instruments. (2020)
- Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele. (2020)
- A review on neuroimaging studies of genetic and environmental influences on early brain development. (2019)
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
- Imaging structural and functional brain development in early childhood. (2018)
- ApoE Regulates the Development of Adult Newborn Hippocampal Neurons. (2018)
- Gene-environment interactions in development and disease. (2017)
- Gray matter maturation and cognition in children with different APOE ε genotypes. (2016)
- Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. (2016)
- Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. (2016)
- Direct Transcriptional Effects of Apolipoprotein E. (2016)
- Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. (2014)
- Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. (2014)
- New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. (2014)
- ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
- In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
- Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. (2012)
- Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. (2012)
- Apolipoprotein E: from lipid transport to neurobiology. (2011)
- Transgenic mouse models of Alzheimer's disease. (2010)
- Structural MRI of pediatric brain development: what have we learned and where are we going? (2010)
- A general factor of brain white matter integrity predicts information processing speed in healthy older people. (2010)
- The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA. (2009)
- Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. (2001)
Merged raw entities (6)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| apoe ε4 | variant | 27 | 118 |
| allele 4 | gene | — | — |
| apoe ε4 | gene | — | — |
| apoe ε4 risk allele | gene | — | — |
| ε4 | gene | — | — |
| ε4 allele | gene | — | — |