shRNA drug

External links

DrugBank · PubChem

Related entities (2)

Mentioned in (40)

Papers in which this entity is mentioned.

• Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
• FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy. (2025)
• Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain. (2025)
• Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. (2025)
• Global impact of unproductive splicing on human gene expression. (2024)
• Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. (2023)
• FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. (2021)
• Macrophage Polarization States in the Tumor Microenvironment. (2021)
• Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. (2021)
• Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders. (2020)
• Sequence, Structure, and Context Preferences of Human RNA Binding Proteins. (2018)
• mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. (2018)
• Positively selected enhancer elements endow osteosarcoma cells with metastatic competence. (2018)
• EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018)
• Statistical algorithms improve accuracy of gene fusion detection. (2017)
• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
• Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. (2017)
• Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. (2017)
• PGBD5 promotes site-specific oncogenic mutations in human tumors. (2017)
• Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice. (2016)
• Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis. (2016)
• Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. (2015)
• Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. (2014)
• MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens. (2014)
• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. (2014)
• Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. (2014)
• EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. (2014)
• Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer. (2013)
• Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells. (2013)
• LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. (2013)
• Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol. (2012)
• Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. (2012)
• Novel mutations target distinct subgroups of medulloblastoma. (2012)
• Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. (2012)
• CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. (2011)
• Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
• Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation. (2010)
• Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (2010)
• Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. (2010)
• An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. (2009)

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