Methadone drug
Evidence from:
primary |
all sources
Related entities (22)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| Methadone | interacts_with | cAMP | — | 1 |
| Methadone | protective_against | cocaine | — | 1 |
| Methadone | protective_against | craving | — | 3 |
| Methadone | protective_against | drug dependence | — | 1 |
| Methadone | interacts_with | heavy drinking | — | 1 |
| Methadone | protective_against | heavy drinking | — | 1 |
| Methadone | associated_with | heavy drinking | — | 1 |
| Methadone | regulates | HPA axis | — | 1 |
| Methadone | associated_with | opioid dependence | — | 1 |
| Methadone | protective_against | opioid dependence | — | 1 |
| Methadone | targets | Opioid system | — | 1 |
| Methadone | protective_against | opioid withdrawal | — | 1 |
| Methadone | interacts_with | OPRM1 | — | 1 |
| Methadone | associated_with | OPRM1 | — | 1 |
| Methadone | targets | OPRM1 | — | 3 |
| Methadone | regulates | orbitofrontal cortex | — | 1 |
| Methadone | associated_with | osteoarthritis | — | 1 |
| Methadone | regulates | prefrontal cortex | — | 1 |
| Methadone | protective_against | withdrawal | — | 2 |
| OPRM1 | targets | Methadone | — | 1 |
| OPRM1 | associated_with | Methadone | — | 1 |
| rs73568641 | associated_with | Methadone | 2.8e-08 | 2 |
Mentioned in (31)
Papers in which this entity is mentioned.
- Punitive legal responses to prenatal drug use in the United States: A survey of state policies and systematic review of their public health impacts. (2024)
- Racial/Ethnic Disparity in Association Between Fetal Alcohol Syndrome and Alcohol Intake During Pregnancy: Multisite Retrospective Cohort Study. (2023)
- Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond. (2022)
- Association Between Benzodiazepine or Z-Drug Prescriptions and Drug-Related Poisonings Among Patients Receiving Buprenorphine Maintenance: A Case-Crossover Analysis. (2021)
- Genetics of substance use disorders in the era of big data. (2021)
- Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling. (2020)
- A randomized controlled trial of screening and brief interventions for substance misuse in reproductive health. (2018)
- Human Genetics of Addiction: New Insights and Future Directions. (2018)
- The gestational foundation of sex differences in development and vulnerability. (2017)
- Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis. (2016)
- Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum. (2016)
- Functional Connectivity Disruption in Neonates with Prenatal Marijuana Exposure. (2015)
- Prenatal drug exposure affects neonatal brain functional connectivity. (2015)
- Pharmacogenetics of OPRM1. (2014)
- Effects of prenatal alcohol exposure on testosterone and pubertal development. (2014)
- Gabapentin treatment for alcohol dependence: a randomized clinical trial. (2014)
- Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects. (2013)
- Fetal alcohol-related growth restriction from birth through young adulthood and moderating effects of maternal prepregnancy weight. (2013)
- The genetics of the opioid system and specific drug addictions. (2012)
- Sex differences amongst dependent heroin users: histories, clinical characteristics and predictors of other substance dependence. (2011)
- Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. (2011)
- Haplotype block structure of the genomic region of the mu opioid receptor gene. (2011)
- Pharmacological treatment of cannabis dependence. (2011)
- Adolescent initiation of licit and illicit substance use: Impact of intrauterine exposures and post-natal exposure to violence. (2011)
- Effect of motivational interviewing on reduction of alcohol use. (2010)
- Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (2010)
- Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals. (2009)
- From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. (2009)
- Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis. (2009)
- Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. (2009)
- EEG biofeedback as a treatment for substance use disorders: review, rating of efficacy, and recommendations for further research. (2008)
Merged raw entities (3)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| methadone | drug | 31 | 45 |
| methadone dose | phenotype | 3 | 3 |
| methadone dosing | drug | — | — |