TP53 gene

Aliases

P53, TP53, Trp53, p53, p53 knockdown, p53KD, tumor protein p53

External links

NCBI Gene · Ensembl · GeneCards · UniProt

Related entities (4)

Mentioned in (192)

Papers in which this entity is mentioned.

• A guide to transcriptomic deconvolution in cancer. (2026)
• Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types. (2026)
• Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models. (2026)
• Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
• Whole-genome landscapes of 1,364 breast cancers. (2026)
• Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort. (2026)
• Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
• Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States. (2025)
• Extrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma. (2025)
• Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers. (2025)
• FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy. (2025)
• Multigenerational cell tracking of DNA replication and heritable DNA damage. (2025)
• Tumour-wide RNA splicing aberrations generate actionable public neoantigens. (2025)
• Functional analysis of cancer-associated germline risk variants. (2025)
• Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. (2025)
• MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. (2025)
• Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. (2024)
• CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. (2024)
• Sequence modeling and design from molecular to genome scale with Evo. (2024)
• Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning. (2024)
• Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)
• Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology. (2024)
• The Application of Long-Read Sequencing to Cancer. (2024)
• Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma. (2023)
• Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patients (2023)
• Heritable defects in telomere and mitotic function selectively predispose to sarcomas. (2023)
• Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors. (2023)
• Deterministic evolution and stringent selection during preneoplasia. (2023)
• Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects. (2023)
• Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers. (2023)
• Towards understandings of serine/arginine-rich splicing factors. (2023)
• RNA splicing dysregulation and the hallmarks of cancer. (2023)
• Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. (2022)
• Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer. (2022)
• Explainable multiview framework for dissecting spatial relationships from highly multiplexed data. (2022)
• Cell-free DNA technologies for the analysis of brain cancer. (2022)
• The pro-apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation-stage alcohol exposure. (2022)
• Single-cell genomic variation induced by mutational processes in cancer. (2022)
• Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers. (2022)
• Circulating Tumor DNA as a Biomarker in Patients With Stage III and IV Wilms Tumor: Analysis From a Children's Oncology Group Trial, AREN0533. (2022)
• Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma. (2022)
• Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology. (2021)
• Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors. (2021)
• Nanopore sequencing technology, bioinformatics and applications. (2021)
• Application of third-generation sequencing in cancer research. (2021)
• Evaluating the transcriptional fidelity of cancer models. (2021)
• Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. (2021)
• A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. (2021)
• Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish. (2021)
• kataegis: an R package for identification and visualization of the genomic localized hypermutation regions using high-throughput sequencing. (2021)
• Biologically informed deep neural network for prostate cancer discovery. (2021)
• Accurate detection of circulating tumor DNA using nanopore consensus sequencing. (2021)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
• Simultaneous single cell measurements of intranuclear proteins and gene expression (2021)
• Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. (2021)
• Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X. (2020)
• Immuno-genomic landscape of osteosarcoma. (2020)
• Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring. (2020)
• Pan-cancer analysis of whole genomes. (2020)
• Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. (2020)
• Inferring structural variant cancer cell fraction. (2020)
• Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma. (2020)
• Emerging Roles of SRSF3 as a Therapeutic Target for Cancer. (2020)
• Transcriptome-Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure. (2020)
• Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. (2020)
• Effects of chronic intermittent ethanol exposure and withdrawal on neuroblastoma cell transcriptome. (2020)
• Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. (2020)
• Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA. (2020)
• Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. (2019)
• Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. (2019)
• CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers. (2019)
• Super-enhancers: critical roles and therapeutic targets in hematologic malignancies. (2019)
• Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019)
• Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. (2019)
• The mutational constraint spectrum quantified from variation in 141,456 humans (2019)
• The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. (2019)
• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study. (2019)
• Designing combination therapies with modeling chaperoned machine learning. (2019)
• Ethanol activates immune response in lymphoblastoid cells. (2019)
• Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients. (2019)
• Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
• Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in -rearranged lung cancer. (2019)
• Assessment of tumor mutation burden calculation from gene panel sequencing data. (2019)
• The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. (2019)
• RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. (2019)
• Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. (2019)
• A Compendium of Mutational Signatures of Environmental Agents. (2019)
• Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
• The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer. (2018)
• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. (2018)
• Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. (2018)
• Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. (2018)
• Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors. (2018)
• Quantification of subclonal selection in cancer from bulk sequencing data. (2018)
• Mutational processes shape the landscape of TP53 mutations in human cancer. (2018)
• Comprehensive Characterization of Cancer Driver Genes and Mutations. (2018)
• Enhanced detection of circulating tumor DNA by fragment size analysis. (2018)
• Genome doubling shapes the evolution and prognosis of advanced cancers. (2018)
• The Human Transcription Factors. (2018)
• Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line. (2018)
• The Immune Landscape of Cancer. (2018)
• Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. (2018)
• Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. (2018)
• Tumor fraction in cell-free DNA as a biomarker in prostate cancer. (2018)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2018)
• Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. (2018)
• Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. (2018)
• SvABA: genome-wide detection of structural variants and indels by local assembly. (2018)
• Patterns and mechanisms of structural variations in human cancer. (2018)
• Copy number signatures and mutational processes in ovarian carcinoma. (2018)
• Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. (2017)
• OncoKB: A Precision Oncology Knowledge Base. (2017)
• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. (2017)
• Universal Patterns of Selection in Cancer and Somatic Tissues. (2017)
• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. (2017)
• Integrative clustering of multi-level 'omic data based on non-negative matrix factorization algorithm. (2017)
• Patient-derived xenografts undergo mouse-specific tumor evolution. (2017)
• Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. (2017)
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. (2017)
• CScape: a tool for predicting oncogenic single-point mutations in the cancer genome. (2017)
• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (2017)
• Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. (2017)
• PGBD5 promotes site-specific oncogenic mutations in human tumors. (2017)
• Copy-number signatures and mutational processes in ovarian carcinoma (2017)
• Clinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience. (2017)
• B lymphocytes and cancer: a love-hate relationship. (2016)
• Exploring genomic alteration in pediatric cancer using ProteinPaint. (2016)
• New insights into the generation and role of de novo mutations in health and disease. (2016)
• Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors. (2016)
• Fragment Length of Circulating Tumor DNA. (2016)
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (2016)
• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. (2016)
• Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
• Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice. (2016)
• GenVisR: Genomic Visualizations in R. (2016)
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. (2015)
• The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS. (2015)
• Recurrent somatic mutations in regulatory regions of human cancer genomes. (2015)
• Integrative clinical genomics of advanced prostate cancer. (2015)
• Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia. (2015)
• ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients. (2015)
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
• Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth. (2015)
• Germline Mutations in Predisposition Genes in Pediatric Cancer. (2015)
• Comprehensive genomic profiles of small cell lung cancer. (2015)
• Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. (2015)
• MBASED: allele-specific expression detection in cancer tissues and cell lines. (2014)
• Unraveling the clonal hierarchy of somatic genomic aberrations. (2014)
• RADIA: RNA and DNA integrated analysis for somatic mutation detection. (2014)
• MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens. (2014)
• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. (2014)
• PVT1 dependence in cancer with MYC copy-number increase. (2014)
• Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. (2014)
• Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (2014)
• An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. (2014)
• Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. (2014)
• Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). (2014)
• Clonal evolution in hematological malignancies and therapeutic implications. (2014)
• TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data. (2014)
• EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. (2014)
• The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. (2014)
• Cancer genome landscapes. (2013)
• Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. (2013)
• Signatures of mutational processes in human cancer. (2013)
• A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. (2013)
• Mutational heterogeneity in cancer and the search for new cancer-associated genes. (2013)
• Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. (2013)
• Emerging landscape of oncogenic signatures across human cancers. (2013)
• Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. (2013)
• RNA splicing: a new player in the DNA damage response. (2013)
• Computational approaches to identify functional genetic variants in cancer genomes. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• The genomic landscape of hypodiploid acute lymphoblastic leukemia. (2013)
• Pan-cancer patterns of somatic copy number alteration. (2013)
• Absolute quantification of somatic DNA alterations in human cancer. (2012)
• High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. (2012)
• Molecular genetics of B-precursor acute lymphoblastic leukemia. (2012)
• Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. (2012)
• Mutational processes molding the genomes of 21 breast cancers. (2012)
• Novel mutations target distinct subgroups of medulloblastoma. (2012)
• Patient-derived tumour xenografts as models for oncology drug development. (2012)
• Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. (2012)
• BRCA1 and BRCA2: different roles in a common pathway of genome protection. (2011)
• Functional consequences of developmentally regulated alternative splicing. (2011)
• Mechanisms and consequences of alternative polyadenylation. (2011)
• Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. (2011)
• Allele-specific copy number analysis of tumors. (2010)
• Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. (2009)
• Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results. (2008)
• MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. (2008)
• MDM2 and MDM4: p53 regulators as targets in anticancer therapy. (2007)
• Accurate and reliable high-throughput detection of copy number variation in the human genome. (2006)

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