CDKN2A gene

Aliases

Arf, CDKN2A, CDNK2A, Ink4a, Ink4a/Arf, Ink4a/Arf locus, cdkn2a, p16

External links

NCBI Gene · Ensembl · GeneCards · UniProt

Related entities (2)

Mentioned in (87)

Papers in which this entity is mentioned.

• Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models. (2026)
• Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States. (2025)
• Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers. (2025)
• Chromosomal instability as a driver of cancer progression. (2025)
• Functional analysis of cancer-associated germline risk variants. (2025)
• MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. (2025)
• Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. (2024)
• CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. (2024)
• Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning. (2024)
• Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)
• The Application of Long-Read Sequencing to Cancer. (2024)
• Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma. (2023)
• Heritable defects in telomere and mitotic function selectively predispose to sarcomas. (2023)
• Deterministic evolution and stringent selection during preneoplasia. (2023)
• At the dawn: cell-free DNA fragmentomics and gene regulation. (2022)
• Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. (2022)
• Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma. (2022)
• Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology. (2021)
• Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors. (2021)
• Application of third-generation sequencing in cancer research. (2021)
• Therapeutic Implications of Germline Testing in Patients With Advanced Cancers. (2021)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
• Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X. (2020)
• Pan-cancer analysis of whole genomes. (2020)
• Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. (2020)
• Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma. (2020)
• Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature. (2020)
• Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. (2019)
• The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. (2019)
• VCF2CNA: A tool for efficiently detecting copy-number alterations in VCF genotype data and tumor purity. (2019)
• Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
• Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. (2018)
• Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. (2018)
• Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. (2018)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2018)
• Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. (2018)
• The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions. (2018)
• Patterns and mechanisms of structural variations in human cancer. (2018)
• Universal Patterns of Selection in Cancer and Somatic Tissues. (2017)
• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. (2017)
• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (2017)
• A method to reduce ancestry related germline false positives in tumor only somatic variant calling. (2017)
• Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors. (2016)
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (2016)
• FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing. (2016)
• Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
• Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia. (2016)
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. (2015)
• Recurrent somatic mutations in regulatory regions of human cancer genomes. (2015)
• Integrative clinical genomics of advanced prostate cancer. (2015)
• Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia. (2015)
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
• Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth. (2015)
• Comprehensive genomic profiles of small cell lung cancer. (2015)
• Hidden Markov Model-Based CNV Detection Algorithms for Illumina Genotyping Microarrays. (2014)
• RADIA: RNA and DNA integrated analysis for somatic mutation detection. (2014)
• The role of BAF (mSWI/SNF) complexes in mammalian neural development. (2014)
• Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. (2014)
• Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). (2014)
• The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. (2014)
• Cancer genome landscapes. (2013)
• Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. (2013)
• Mutational heterogeneity in cancer and the search for new cancer-associated genes. (2013)
• Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. (2013)
• Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. (2013)
• Emerging landscape of oncogenic signatures across human cancers. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• The genomic landscape of hypodiploid acute lymphoblastic leukemia. (2013)
• Pan-cancer patterns of somatic copy number alteration. (2013)
• LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. (2013)
• Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. (2012)
• Molecular genetics of B-precursor acute lymphoblastic leukemia. (2012)
• Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. (2012)
• VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. (2012)
• Massive genomic rearrangement acquired in a single catastrophic event during cancer development. (2011)
• Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. (2011)
• Molecular mechanisms of long noncoding RNAs. (2011)
• Integrative analysis of the melanoma transcriptome. (2010)
• DNA copy number, including telomeres and mitochondria, assayed using next-generation sequencing. (2010)
• Linking functional decline of telomeres, mitochondria and stem cells during ageing. (2010)
• rSW-seq: algorithm for detection of copy number alterations in deep sequencing data. (2010)
• Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. (2010)
• Down syndrome--recent progress and future prospects. (2009)
• Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results. (2008)
• Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. (2007)
• Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (2005)

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