Myc gene

Aliases

CMYC, MYC, c-MYC, c-Myc, c-myc, cMYC, cMyc

External links

NCBI Gene · Ensembl · GeneCards · UniProt

Related entities (5)

Mentioned in (129)

Papers in which this entity is mentioned.

• Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models. (2026)
• Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
• Whole-genome landscapes of 1,364 breast cancers. (2026)
• Enhancer activation from transposable elements in extrachromosomal DNA. (2025)
• Extrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma. (2025)
• Chromosomal instability as a driver of cancer progression. (2025)
• Functional analysis of cancer-associated germline risk variants. (2025)
• Three-dimensional genome landscape of primary human cancers. (2025)
• Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. (2025)
• MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. (2025)
• Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. (2024)
• Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. (2024)
• Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)
• MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library. (2024)
• Deterministic evolution and stringent selection during preneoplasia. (2023)
• Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing. (2023)
• Towards understandings of serine/arginine-rich splicing factors. (2023)
• RNA splicing dysregulation and the hallmarks of cancer. (2023)
• Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. (2022)
• Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. (2022)
• Single-cell genomic variation induced by mutational processes in cancer. (2022)
• Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma. (2022)
• Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers. (2022)
• Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma. (2022)
• Enhanced detection of minimal residual disease by targeted sequencing of phased variants in circulating tumor DNA. (2021)
• Application of third-generation sequencing in cancer research. (2021)
• Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. (2021)
• A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. (2021)
• Integrative reconstruction of cancer genome karyotypes using InfoGenomeR. (2021)
• Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases. (2021)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
• Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. (2021)
• Pan-cancer analysis of whole genomes. (2020)
• Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. (2020)
• Transcriptome-Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure. (2020)
• Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
• Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. (2020)
• Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. (2020)
• Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers. (2020)
• AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications. (2020)
• Modification of stem cell states by alcohol and acetaldehyde. (2020)
• Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. (2019)
• Super-enhancers: critical roles and therapeutic targets in hematologic malignancies. (2019)
• Exploring the landscape of focal amplifications in cancer using AmpliconArchitect. (2019)
• Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. (2019)
• The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. (2019)
• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study. (2019)
• CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. (2019)
• Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
• Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
• Circular DNA elements of chromosomal origin are common in healthy human somatic tissue. (2018)
• Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors. (2018)
• Enhanced detection of circulating tumor DNA by fragment size analysis. (2018)
• The Human Transcription Factors. (2018)
• Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line. (2018)
• Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. (2018)
• Patterns and mechanisms of structural variations in human cancer. (2018)
• Copy number signatures and mutational processes in ovarian carcinoma. (2018)
• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. (2017)
• One-Carbon Metabolism in Health and Disease. (2017)
• Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. (2017)
• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
• Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. (2017)
• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (2017)
• Copy-number signatures and mutational processes in ovarian carcinoma (2017)
• Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. (2017)
• Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin. (2016)
• Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. (2016)
• Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers. (2016)
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (2016)
• Oxidative stress signaling to chromatin in health and disease. (2016)
• Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. (2016)
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. (2015)
• Integrative clinical genomics of advanced prostate cancer. (2015)
• Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. (2015)
• CTCF as a multifunctional protein in genome regulation and gene expression. (2015)
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
• GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015)
• BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. (2015)
• Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. (2015)
• The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing. (2015)
• Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. (2015)
• Comprehensive genomic profiles of small cell lung cancer. (2015)
• Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. (2015)
• Unraveling the clonal hierarchy of somatic genomic aberrations. (2014)
• Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. (2014)
• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. (2014)
• Induced neuronal reprogramming. (2014)
• PVT1 dependence in cancer with MYC copy-number increase. (2014)
• Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood. (2014)
• Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. (2014)
• Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (2014)
• Clonal evolution in hematological malignancies and therapeutic implications. (2014)
• RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts. (2013)
• Cancer genome landscapes. (2013)
• The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. (2013)
• Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. (2013)
• Fusion genes and their discovery using high throughput sequencing. (2013)
• Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (2013)
• Emerging landscape of oncogenic signatures across human cancers. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• The genomic landscape of hypodiploid acute lymphoblastic leukemia. (2013)
• Pan-cancer patterns of somatic copy number alteration. (2013)
• LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. (2013)
• Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. (2012)
• High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. (2012)
• Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. (2012)
• Molecular genetics of B-precursor acute lymphoblastic leukemia. (2012)
• Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. (2012)
• Mutational processes molding the genomes of 21 breast cancers. (2012)
• Novel mutations target distinct subgroups of medulloblastoma. (2012)
• Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. (2012)
• An integrated encyclopedia of DNA elements in the human genome. (2012)
• Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. (2012)
• VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. (2012)
• Massive genomic rearrangement acquired in a single catastrophic event during cancer development. (2011)
• Mechanisms and consequences of alternative polyadenylation. (2011)
• The role of zinc in the modulation of neuronal proliferation and apoptosis. (2010)
• Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. (2010)
• Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure. (2010)
• Cellular metabolic stress: considering how cells respond to nutrient excess. (2010)
• A novel and universal method for microRNA RT-qPCR data normalization. (2009)
• Expansion of the human mu-opioid receptor gene architecture: novel functional variants. (2009)
• Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy. (2009)
• 3' end mRNA processing: molecular mechanisms and implications for health and disease. (2008)
• A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. (2008)
• Choline: critical role during fetal development and dietary requirements in adults. (2006)
• Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. (2005)
• Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (2005)

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