GAPDH gene

Aliases

glyceraldehyde-3-phosphate dehydrogenase, glyceraldehydes-3-phosphate dehydrogenase

External links

NCBI Gene · Ensembl · GeneCards · UniProt

Related entities (3)

Mentioned in (132)

Papers in which this entity is mentioned.

• Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics. (2026)
• Functional analysis of cancer-associated germline risk variants. (2025)
• MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. (2025)
• Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. (2024)
• Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. (2024)
• Alcohol blunts pregnancy-mediated insulin resistance and reduces fetal brain glucose despite elevated fetal gluconeogenesis, and these changes associate with fetal weight outcomes. (2023)
• Single-cell genomic variation induced by mutational processes in cancer. (2022)
• Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. (2022)
• FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. (2021)
• Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription. (2021)
• Early-life nicotine or cotinine exposure produces long-lasting sleep alterations and downregulation of hippocampal corticosteroid receptors in adult mice. (2021)
• Neurotoxic reactive astrocytes induce cell death via saturated lipids. (2021)
• Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube. (2021)
• Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription. (2020)
• Tead transcription factors differentially regulate cortical development. (2020)
• Satb2 is required for the regionalization of retrosplenial cortex. (2020)
• Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations. (2020)
• Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans. (2019)
• Genetic compensation triggered by mutant mRNA degradation. (2019)
• Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus. (2019)
• RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types. (2019)
• The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. (2019)
• Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. (2019)
• A Compendium of Mutational Signatures of Environmental Agents. (2019)
• mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. (2018)
• Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. (2018)
• Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission. (2018)
• Lower mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus. (2018)
• Positively selected enhancer elements endow osteosarcoma cells with metastatic competence. (2018)
• Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. (2018)
• EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018)
• Statistical algorithms improve accuracy of gene fusion detection. (2017)
• The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies. (2017)
• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
• Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. (2017)
• Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. (2017)
• Sexual Dimorphism of miRNAs Secreted by Bovine -produced Embryos. (2017)
• Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. (2017)
• Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure. (2017)
• Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. (2017)
• Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain. (2017)
• Efficient derivation of microglia-like cells from human pluripotent stem cells. (2016)
• Inhibition of Mammary Cancer Progression in Fetal Alcohol Exposed Rats by β-Endorphin Neurons. (2016)
• CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. (2016)
• A role for human homologous recombination factors in suppressing microhomology-mediated end joining. (2016)
• Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors. (2016)
• Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. (2016)
• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. (2016)
• Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice. (2016)
• Oxidative stress signaling to chromatin in health and disease. (2016)
• Direct Transcriptional Effects of Apolipoprotein E. (2016)
• Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. (2016)
• Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. (2015)
• CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation. (2015)
• EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. (2015)
• Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. (2015)
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
• Position-specific binding of FUS to nascent RNA regulates mRNA length. (2015)
• Prenatal ethanol exposure alters adult hippocampal VGLUT2 expression with concomitant changes in promoter DNA methylation, H3K4 trimethylation and miR-467b-5p levels. (2015)
• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. (2014)
• Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells. (2014)
• Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. (2014)
• PVT1 dependence in cancer with MYC copy-number increase. (2014)
• EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. (2014)
• Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. (2014)
• The role of NADPH oxidase in a mouse model of fetal alcohol syndrome. (2014)
• Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing POMC neurons of the hypothalamus. (2013)
• RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts. (2013)
• Identification of cell-specific patterns of reference gene stability in quantitative reverse-transcriptase polymerase chain reaction studies of embryonic, placental and neural stem models of prenatal ethanol exposure. (2013)
• Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. (2013)
• G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. (2013)
• ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
• Interleukin-6 (IL-6) receptor/IL-6 fusion protein (Hyper IL-6) effects on the neonatal mouse brain: possible role for IL-6 trans-signaling in brain development and functional neurobehavioral outcomes. (2013)
• Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. (2013)
• Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation. (2013)
• LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. (2013)
• Nitric oxide rescues thalidomide mediated teratogenicity. (2012)
• Cannabinoid receptor 1 signaling in embryo neurodevelopment. (2012)
• Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets. (2012)
• Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. (2012)
• Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. (2012)
• HDAC1 regulates fear extinction in mice. (2012)
• Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. (2012)
• Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. (2012)
• Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats. (2012)
• Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. (2012)
• Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. (2012)
• Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. (2012)
• Chronic intermittent ethanol exposure and its removal induce a different miRNA expression pattern in primary cortical neuronal cultures. (2012)
• Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure. (2012)
• Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. (2012)
• Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. (2011)
• Regulation of ethanol-sensitive EAAT2 expression through adenosine A1 receptor in astrocytes. (2011)
• Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. (2011)
• Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet. (2011)
• Candidate placental biomarkers for intrauterine alcohol exposure. (2011)
• Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. (2011)
• Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1. (2011)
• MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. (2011)
• CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. (2011)
• MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. (2011)
• AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. (2011)
• Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. (2011)
• Calcium-mediated repression of β-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome. (2011)
• Alteration of gene expression by alcohol exposure at early neurulation. (2011)
• Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. (2010)
• Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes. (2010)
• Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (2010)
• Long noncoding RNAs with enhancer-like function in human cells. (2010)
• The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. (2010)
• Conserved role of intragenic DNA methylation in regulating alternative promoters. (2010)
• The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
• The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
• The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. (2009)
• Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders. (2009)
• Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. (2009)
• Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors. (2009)
• Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. (2009)
• Computation for ChIP-seq and RNA-seq studies. (2009)
• The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. (2008)
• Mechanism of alcohol-induced oxidative stress and neuronal injury. (2008)
• Defining diversity, specialization, and gene specificity in transcriptomes through information theory. (2008)
• A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. (2008)
• Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. (2008)
• Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model. (2008)
• Maternal immune activation alters fetal brain development through interleukin-6. (2007)
• PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. (2007)
• Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. (2006)
• Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (2005)
• Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. (2003)
• Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. (2002)
• Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. (1995)

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