CYP2E1 gene

Aliases: CYP2E1, Cytochrome P450 2E1, MEOS, cytochrome P450 2E1, microsomal cytochrome P4502E1
External links: NCBI Gene · Ensembl · GeneCards · UniProt

Evidence from: primary | all sources

Related entities (41)

Subject	Relation	Object	p-value	Evidence
alcohol	regulates	CYP2E1	—	2
alcohol	interacts_with	CYP2E1	—	1
CYP2E1	regulates	4-hydroxynonenal	—	1
CYP2E1	interacts_with	acetaldehyde	—	2
CYP2E1	interacts_with	acetaminophen	—	1
CYP2E1	targets	alcohol	—	1
CYP2E1	risk_factor_for	alcoholic liver disease	—	1
CYP2E1	biomarker_for	alcoholism	—	1
CYP2E1	associated_with	alcohol sensitivity	—	1
CYP2E1	associated_with	alcohol use disorders	—	1
CYP2E1	risk_factor_for	cancer	—	1
CYP2E1	interacts_with	Catalase	—	1
CYP2E1	regulates	Cd14	—	1
CYP2E1	expressed_in	endoplasmic reticulum	—	1
CYP2E1	interacts_with	ethanol group	—	3
CYP2E1	targets	ethanol group	—	2
CYP2E1	risk_factor_for	fetal alcohol syndrome	—	1
CYP2E1	associated_with	hepatocellular carcinoma	—	1
CYP2E1	regulates	hydrogen peroxide	—	1
CYP2E1	risk_factor_for	liver injury	—	1
CYP2E1	expressed_in	mutant mice	—	1
CYP2E1	interacts_with	NADPH	—	1
CYP2E1	regulates	NADPH oxidase	—	1
CYP2E1	associated_with	oxidative stress	—	1
CYP2E1	risk_factor_for	oxidative stress	—	1
CYP2E1	interacts_with	posterior region	—	1
CYP2E1	regulates	reactive oxygen species	—	1
CYP2E1	interacts_with	ROS	—	1
CYP2E1	associated_with	ROS	—	2
CYP2E1	regulates	Tlr4	—	1
CYP2E1	regulates	TNF-α	—	1
ethanol group	interacts_with	CYP2E1	—	1
ethanol group	regulates	CYP2E1	—	3
ethanol group	associated_with	CYP2E1	—	1
high-fat diet	regulates	CYP2E1	—	1
NADPH	associated_with	CYP2E1	—	1
nicotine	regulates	CYP2E1	—	1
nicotine	interacts_with	CYP2E1	—	1
ROS	associated_with	CYP2E1	—	1
RXR	regulates	CYP2E1	—	1
tobacco use	interacts_with	CYP2E1	—	1

Mentioned in (37)

Papers in which this entity is mentioned.

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
Pathogenesis of Alcoholic Fatty Liver a Narrative Review. (2023)
Pathogenesis of Alcohol-Associated Fatty Liver: Lessons From Transgenic Mice. (2022)
Beneficial Effects of Betaine: A Comprehensive Review. (2021)
Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
Modification of stem cell states by alcohol and acetaldehyde. (2020)
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. (2019)
Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE. (2018)
Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity. (2017)
Ethanol itself is a holoprosencephaly-inducing teratogen. (2017)
Lipids and Oxidative Stress Associated with Ethanol-Induced Neurological Damage. (2016)
Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. (2016)
The Genetics of Fetal Alcohol Spectrum Disorders. (2016)
Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. (2015)
An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. (2014)
Gene-ethanol interactions underlying fetal alcohol spectrum disorders. (2014)
Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder. (2014)
Developmental age strengthens barriers to ethanol accumulation in zebrafish. (2014)
Alcohol metabolism and epigenetics changes. (2013)
In utero alcohol exposure, epigenetic changes, and their consequences. (2013)
Perinatal exposure to alcohol: implications for lung development and disease. (2013)
The genetics of alcohol dependence: advancing towards systems-based approaches. (2012)
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. (2012)
Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure. (2012)
The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. (2011)
Effects of ethanol on physiological retinoic acid levels. (2011)
Genetic and epigenetic insights into fetal alcohol spectrum disorders. (2010)
The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. (2010)
The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. (2009)
Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease. (2009)
Mechanism of alcohol-induced oxidative stress and neuronal injury. (2008)
Chronic ethanol consumption leads to disruption of vitamin D3 homeostasis associated with induction of renal 1,25 dihydroxyvitamin D3-24-hydroxylase (CYP24A1). (2008)
Genetic and environmental factors in complex neurodevelopmental disorders. (2007)
Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007)
Modeling alcohol's effects on organs in animal models. (2000)

Merged raw entities (4)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
cyp2e1	gene	37	114
cytochrome p450 2e1	gene	2	2
meos	gene	—	—
microsomal cytochrome p4502e1	gene	—	—