TNF-α drug
Evidence from:
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Related entities (31)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| ABO | associated_with | TNF-α | — | 1 |
| acetaldehyde | regulates | TNF-α | — | 1 |
| acetaldehyde | risk_factor_for | TNF-α | — | 1 |
| acute withdrawal | regulates | TNF-α | — | 1 |
| chronic alcoholism | regulates | TNF-α | — | 1 |
| CYP2E1 | regulates | TNF-α | — | 1 |
| ERK1/2 | regulates | TNF-α | — | 1 |
| ethanol group | associated_with | TNF-α | — | 1 |
| ethanol group | regulates | TNF-α | — | 1 |
| hepatic steatosis | associated_with | TNF-α | — | 1 |
| LPS | risk_factor_for | TNF-α | — | 1 |
| LPS | regulates | TNF-α | — | 2 |
| NF-κB | regulates | TNF-α | — | 1 |
| NFκB | regulates | TNF-α | — | 1 |
| PD98059 | regulates | TNF-α | — | 1 |
| PPARG | regulates | TNF-α | — | 1 |
| PPARγ | regulates | TNF-α | — | 1 |
| RXR | regulates | TNF-α | — | 1 |
| SYP | regulates | TNF-α | — | 1 |
| TGF-β | regulates | TNF-α | — | 1 |
| TNF-α | risk_factor_for | alcoholic liver disease | — | 1 |
| TNF-α | regulates | Autophagy | — | 1 |
| TNF-α | regulates | GABAA receptor | — | 1 |
| TNF-α | regulates | Gabra1 | — | 1 |
| TNF-α | regulates | IRF1 | — | 1 |
| TNF-α | regulates | mTOR | — | 1 |
| TNF-α | risk_factor_for | multiple sclerosis | — | 1 |
| TNF-α | risk_factor_for | oligodendrocytes | — | 1 |
| TNF-α | regulates | PPARγ | — | 1 |
| TNF-α | regulates | ROS | — | 1 |
| TNF-α | regulates | RXR | — | 1 |
Mentioned in (85)
Papers in which this entity is mentioned.
- Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort. (2025)
- Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort. (2025)
- Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. (2024)
- Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD). (2024)
- Pathogenesis of Alcoholic Fatty Liver a Narrative Review. (2023)
- Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
- Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects. (2023)
- H-MRS neurometabolite profiles and motor development in school-aged children who are HIV-exposed uninfected: a birth cohort study. (2023)
- Alternative splicing events as peripheral biomarkers for motor learning deficit caused by adverse prenatal environments. (2023)
- Chronic oligodendrocyte injury in central nervous system pathologies. (2022)
- Beneficial Effects of Betaine: A Comprehensive Review. (2021)
- Inflammatory modulation of the associations between prenatal maternal depression and neonatal brain. (2021)
- Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders. (2021)
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders. (2021)
- Macrophage Polarization States in the Tumor Microenvironment. (2021)
- Simultaneous single cell measurements of intranuclear proteins and gene expression (2021)
- Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure. (2020)
- Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders. (2020)
- Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
- Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. (2020)
- Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review. (2020)
- Peripheral Biomarkers for First-Episode Psychosis-Opportunities from the Neuroinflammatory Hypothesis of Schizophrenia. (2019)
- Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. (2019)
- Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. (2018)
- Sex Differences in Early Postnatal Microglial Colonization of the Developing Rat Hippocampus Following a Single-Day Alcohol Exposure. (2018)
- Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy. (2018)
- PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. (2018)
- Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders. (2018)
- Effects of early-life adversity on immune function are mediated by prenatal environment: Role of prenatal alcohol exposure. (2017)
- Demystifying the cytokine network: Mathematical models point the way. (2017)
- Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder. (2017)
- Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. (2017)
- The effect of alcohol on the differential expression of cluster of differentiation 14 gene, associated pathways, and genetic network. (2017)
- Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders. (2017)
- Fetal sex is associated with maternal stimulated cytokine production, but not serum cytokine levels, in human pregnancy. (2017)
- Evidence for an immune signature of prenatal alcohol exposure in female rats. (2016)
- Inhibition of Mammary Cancer Progression in Fetal Alcohol Exposed Rats by β-Endorphin Neurons. (2016)
- The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming. (2016)
- Pioglitazone blocks ethanol induction of microglial activation and immune responses in the hippocampus, cerebellum, and cerebral cortex in a mouse model of fetal alcohol spectrum disorders. (2015)
- Regulation of calcitriol biosynthesis and activity: focus on gestational vitamin D deficiency and adverse pregnancy outcomes. (2015)
- The association of cord serum cytokines with neurodevelopmental outcomes. (2015)
- The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. (2014)
- Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study. (2014)
- The role of NADPH oxidase in a mouse model of fetal alcohol syndrome. (2014)
- Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. (2013)
- Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. (2013)
- Interleukin-6 (IL-6) receptor/IL-6 fusion protein (Hyper IL-6) effects on the neonatal mouse brain: possible role for IL-6 trans-signaling in brain development and functional neurobehavioral outcomes. (2013)
- Effects of alcohol on the endocrine system. (2013)
- Thalidomide-a notorious sedative to a wonder anticancer drug. (2013)
- VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair. (2013)
- In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
- Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. (2012)
- Inflammaging: disturbed interplay between autophagy and inflammasomes. (2012)
- Myeloid cells in tumor inflammation. (2012)
- Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. (2012)
- Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (2012)
- Plasma cytokine levels in children with autistic disorder and unrelated siblings. (2012)
- Prenatal alcohol exposure alters the course and severity of adjuvant-induced arthritis in female rats. (2012)
- Regulation of cancer progression by β-endorphin neuron. (2012)
- Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response. (2012)
- Teratogenic effects of thalidomide: molecular mechanisms. (2011)
- Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. (2011)
- AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. (2011)
- Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study. (2011)
- Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
- MicroRNAs: master regulators of ethanol abuse and toxicity? (2010)
- i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. (2010)
- COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. (2010)
- Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. (2010)
- Role of microglia in ethanol's apoptotic action on hypothalamic neuronal cells in primary cultures. (2010)
- The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example. (2010)
- The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
- The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
- Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. (2009)
- Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease. (2009)
- The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. (2009)
- Adrenomedullin signaling is necessary for murine lymphatic vascular development. (2008)
- Maternal immune activation alters fetal brain development through interleukin-6. (2007)
- Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. (2005)
- Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death. (2004)
- Myelination is altered in insulin-like growth factor-I null mutant mice. (2002)
- Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. (2001)
- Eotaxin and the attraction of eosinophils to the asthmatic lung. (2001)
- Modeling alcohol's effects on organs in animal models. (2000)
- Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. (1998)
Merged raw entities (8)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| tnf-α | drug | 69 | 207 |
| tumor necrosis factor alpha | drug | 11 | 13 |
| tnf-α | gene | 9 | 16 |
| tnf-alpha | drug | 8 | 12 |
| tnfa | drug | 5 | 6 |
| tumor necrosis factor α | drug | 4 | 5 |
| tnf alpha | drug | 1 | 1 |
| tumor necrosis factor-α | drug | 1 | 1 |