2-AG drug

Aliases: 2-Arachidonoylglycerol, 2-arachidonoylglycerol, 2-arachidonylglycerol, 2‑AG, 2‑arachidonoylglycerol, endogenous 2-AG
External links: DrugBank · PubChem

Evidence from: primary | all sources

Related entities (32)

Subject	Relation	Object	p-value	Evidence
2-AG	associated_with	AA	—	1
2-AG	expressed_in	amygdala	—	1
2-AG	expressed_in	basolateral amygdala	—	2
2-AG	expressed_in	BLA	—	1
2-AG	expressed_in	brain	—	1
2-AG	protective_against	cannabis dependence	—	1
2-AG	protective_against	cannabis withdrawal	—	1
2-AG	interacts_with	CB1 receptor	—	1
2-AG	regulates	CB1 receptor	—	1
2-AG	targets	CB1 receptor	—	1
2-AG	interacts_with	CB2	—	1
2-AG	associated_with	depolarization-induced suppression of inhibition	—	1
2-AG	regulates	depolarization-induced suppression of inhibition	—	1
2-AG	expressed_in	dorsal striatum	—	1
2-AG	expressed_in	dorsolateral prefrontal cortex	—	1
2-AG	regulates	GABA	—	2
2-AG	interacts_with	GABA	—	1
2-AG	regulates	glutamate	—	1
2-AG	interacts_with	oleic acid	—	1
2-AG	expressed_in	ventromedial prefrontal cortex	—	1
acute stress	regulates	2-AG	—	1
acute stress	associated_with	2-AG	0.01	1
BLA	regulates	2-AG	—	1
DAGL	regulates	2-AG	—	2
DAGLA	regulates	2-AG	—	2
FAAH	regulates	2-AG	—	1
GAD1	regulates	2-AG	—	1
glucocorticoid	regulates	2-AG	—	1
MAGL	regulates	2-AG	—	1
MGLL	regulates	2-AG	—	1
SAG	regulates	2-AG	—	1
stress	regulates	2-AG	—	1

Mentioned in (20)

Papers in which this entity is mentioned.

Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling. (2020)
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. (2018)
CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. (2016)
Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice. (2016)
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. (2015)
Endocannabinoids are conserved inhibitors of the Hedgehog pathway. (2015)
Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. (2014)
Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies. (2014)
Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice. (2014)
Neuronal substrates and functional consequences of prenatal cannabis exposure. (2014)
Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity. (2013)
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. (2013)
Cannabinoid receptor 1 signaling in embryo neurodevelopment. (2012)
Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia. (2012)
Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. (2011)
AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. (2011)
Pharmacological treatment of cannabis dependence. (2011)
Cannabis and psychosis/schizophrenia: human studies. (2009)
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. (2009)
Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. (2008)

Merged raw entities (5)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
2-ag	drug	18	105
2-arachidonylglycerol	drug	3	4
2‑arachidonoylglycerol	drug	1	1
2‑ag	drug	—	—
endogenous 2-ag	drug	—	—