PTEN gene

Aliases

phosphatase and tensin homolog

External links

NCBI Gene · Ensembl · GeneCards · UniProt

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Mentioned in (76)

Papers in which this entity is mentioned.

• Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
• Whole-genome landscapes of 1,364 breast cancers. (2026)
• Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
• Chromosomal instability as a driver of cancer progression. (2025)
• CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. (2024)
• Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)
• Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology. (2024)
• Heritable defects in telomere and mitotic function selectively predispose to sarcomas. (2023)
• Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects. (2023)
• Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma. (2022)
• Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology. (2021)
• Most non-canonical proteins uniquely populate the proteome or immunopeptidome. (2021)
• Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors. (2021)
• Evaluating the transcriptional fidelity of cancer models. (2021)
• Biologically informed deep neural network for prostate cancer discovery. (2021)
• Macrophage Polarization States in the Tumor Microenvironment. (2021)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
• Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. (2021)
• Immuno-genomic landscape of osteosarcoma. (2020)
• Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. (2020)
• Emerging Roles of SRSF3 as a Therapeutic Target for Cancer. (2020)
• Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. (2020)
• Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. (2019)
• CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers. (2019)
• Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions. (2019)
• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study. (2019)
• Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients. (2019)
• Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer. (2019)
• Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
• Assessment of tumor mutation burden calculation from gene panel sequencing data. (2019)
• Comprehensive analysis of structural variants in breast cancer genomes using single molecule sequencing (2019)
• Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
• Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. (2018)
• Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. (2018)
• Comprehensive Characterization of Cancer Driver Genes and Mutations. (2018)
• The Immune Landscape of Cancer. (2018)
• Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. (2018)
• Tumor fraction in cell-free DNA as a biomarker in prostate cancer. (2018)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2018)
• Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. (2018)
• Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. (2018)
• Patterns and mechanisms of structural variations in human cancer. (2018)
• Copy number signatures and mutational processes in ovarian carcinoma. (2018)
• OncoKB: A Precision Oncology Knowledge Base. (2017)
• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. (2017)
• Universal Patterns of Selection in Cancer and Somatic Tissues. (2017)
• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (2017)
• Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. (2017)
• Copy-number signatures and mutational processes in ovarian carcinoma (2017)
• Fragment Length of Circulating Tumor DNA. (2016)
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (2016)
• Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
• Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. (2015)
• Recurrent somatic mutations in regulatory regions of human cancer genomes. (2015)
• Integrative clinical genomics of advanced prostate cancer. (2015)
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
• Germline Mutations in Predisposition Genes in Pediatric Cancer. (2015)
• Dissecting FASD through the global transcriptome. (2015)
• Comprehensive genomic profiles of small cell lung cancer. (2015)
• Unraveling the clonal hierarchy of somatic genomic aberrations. (2014)
• Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. (2014)
• Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (2014)
• Cancer genome landscapes. (2013)
• Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. (2013)
• Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. (2013)
• Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. (2013)
• Mutational heterogeneity in cancer and the search for new cancer-associated genes. (2013)
• Commonality in Down and fetal alcohol syndromes. (2013)
• Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. (2013)
• Computational approaches to identify functional genetic variants in cancer genomes. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• Pan-cancer patterns of somatic copy number alteration. (2013)
• High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. (2012)
• Novel mutations target distinct subgroups of medulloblastoma. (2012)
• VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. (2012)
• Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. (2009)

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