PTEN gene
Evidence from:
primary |
all sources
Related entities (11)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| Ctbp2 | regulates | PTEN | — | 1 |
| PTEN | expressed_in | Arabidopsis thaliana | — | 1 |
| PTEN | associated_with | cancer | — | 1 |
| PTEN | expressed_in | CeA | — | 1 |
| PTEN | expressed_in | Danio rerio | — | 1 |
| PTEN | associated_with | intellectual disability | — | 1 |
| PTEN | expressed_in | nucleus accumbens shell | — | 1 |
| PTEN | interacts_with | TP53 | — | 1 |
| PTEN | associated_with | tuberous sclerosis | — | 1 |
| PTENP1 | associated_with | PTEN | — | 1 |
| STK11 | regulates | PTEN | — | 1 |
Mentioned in (100)
Papers in which this entity is mentioned.
- Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships. (2026)
- Whole-genome landscapes of 1,364 breast cancers. (2026)
- Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
- Chromosomal instability as a driver of cancer progression. (2025)
- CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. (2024)
- Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)
- Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology. (2024)
- Heritable defects in telomere and mitotic function selectively predispose to sarcomas. (2023)
- Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects. (2023)
- Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma. (2022)
- Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology. (2021)
- Most non-canonical proteins uniquely populate the proteome or immunopeptidome. (2021)
- Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors. (2021)
- Evaluating the transcriptional fidelity of cancer models. (2021)
- Biologically informed deep neural network for prostate cancer discovery. (2021)
- Macrophage Polarization States in the Tumor Microenvironment. (2021)
- Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
- Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. (2021)
- Immuno-genomic landscape of osteosarcoma. (2020)
- Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. (2020)
- Emerging Roles of SRSF3 as a Therapeutic Target for Cancer. (2020)
- Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. (2020)
- Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. (2019)
- CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers. (2019)
- The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens. (2019)
- Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions. (2019)
- Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study. (2019)
- Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients. (2019)
- Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer. (2019)
- Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
- Assessment of tumor mutation burden calculation from gene panel sequencing data. (2019)
- Comprehensive analysis of structural variants in breast cancer genomes using single molecule sequencing (2019)
- Hippocampal deficits in neurodevelopmental disorders. (2019)
- Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
- Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. (2018)
- Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. (2018)
- Comprehensive Characterization of Cancer Driver Genes and Mutations. (2018)
- The Immune Landscape of Cancer. (2018)
- Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. (2018)
- Tumor fraction in cell-free DNA as a biomarker in prostate cancer. (2018)
- Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2018)
- PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. (2018)
- Regional Differences and Similarities in the Brain Transcriptome for Mice Selected for Ethanol Preference From HS-CC Founders. (2018)
- Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. (2018)
- Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. (2018)
- Patterns and mechanisms of structural variations in human cancer. (2018)
- Copy number signatures and mutational processes in ovarian carcinoma. (2018)
- OncoKB: A Precision Oncology Knowledge Base. (2017)
- HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. (2017)
- Universal Patterns of Selection in Cancer and Somatic Tissues. (2017)
- A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
- Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. (2017)
- Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (2017)
- Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. (2017)
- Copy-number signatures and mutational processes in ovarian carcinoma (2017)
- Fragment Length of Circulating Tumor DNA. (2016)
- Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (2016)
- Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum. (2016)
- Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
- Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. (2015)
- Recurrent somatic mutations in regulatory regions of human cancer genomes. (2015)
- Integrative clinical genomics of advanced prostate cancer. (2015)
- A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
- CtBP2 is an independent prognostic marker that promotes GLI1 induced epithelial-mesenchymal transition in hepatocellular carcinoma. (2015)
- Regulation of mTORC1 by PI3K signaling. (2015)
- Germline Mutations in Predisposition Genes in Pediatric Cancer. (2015)
- Dissecting FASD through the global transcriptome. (2015)
- Comprehensive genomic profiles of small cell lung cancer. (2015)
- Unraveling the clonal hierarchy of somatic genomic aberrations. (2014)
- Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. (2014)
- Effects of Acute Prenatal Exposure to Ethanol on microRNA Expression are Ameliorated by Social Enrichment. (2014)
- Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (2014)
- Gene-ethanol interactions underlying fetal alcohol spectrum disorders. (2014)
- Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders. (2014)
- Cancer genome landscapes. (2013)
- Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. (2013)
- In utero alcohol exposure, epigenetic changes, and their consequences. (2013)
- Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. (2013)
- Alcohol exposure in utero increases susceptibility to prostate tumorigenesis in rat offspring. (2013)
- Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. (2013)
- Distribution of disease-associated copy number variants across distinct disorders of cognitive development. (2013)
- Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. (2013)
- Mutational heterogeneity in cancer and the search for new cancer-associated genes. (2013)
- Commonality in Down and fetal alcohol syndromes. (2013)
- Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. (2013)
- Computational approaches to identify functional genetic variants in cancer genomes. (2013)
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
- Pan-cancer patterns of somatic copy number alteration. (2013)
- High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. (2012)
- Novel mutations target distinct subgroups of medulloblastoma. (2012)
- Regulation of cancer progression by β-endorphin neuron. (2012)
- VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. (2012)
- Teratogenic effects of thalidomide: molecular mechanisms. (2011)
- Molecular mechanisms of long noncoding RNAs. (2011)
- Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. (2011)
- Linking functional decline of telomeres, mitochondria and stem cells during ageing. (2010)
- Histone methylation regulates memory formation. (2010)
- Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes. (2010)
- Cellular metabolic stress: considering how cells respond to nutrient excess. (2010)
- Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. (2009)
Merged raw entities (2)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| pten | gene | 100 | 265 |
| phosphatase and tensin homolog | gene | — | — |