PAU phenotype

Aliases: PAU PRS, PAU meta-analysis, Problematic Alcohol Use, alcohol use disorder, problematic alcohol use

Evidence from: primary | all sources

Related entities (117)

Subject	Relation	Object	p-value	Evidence
ADH1A	risk_factor_for	PAU	—	1
ADH1B	associated_with	PAU	—	1
ADH1B	risk_factor_for	PAU	—	2
ADH1B	biomarker_for	PAU	—	1
ADH1C	risk_factor_for	PAU	—	2
ADH1C	associated_with	PAU	—	1
ADH4	biomarker_for	PAU	—	1
ADH4	associated_with	PAU	2.64e-06	1
ADH4	risk_factor_for	PAU	—	1
ADH5	risk_factor_for	PAU	—	1
ADH5	biomarker_for	PAU	—	1
ADH5	associated_with	PAU	2.64e-06	2
ADH7	associated_with	PAU	2.64e-06	1
ADH gene cluster	associated_with	PAU	—	1
African American	associated_with	PAU	—	1
ARID4A	risk_factor_for	PAU	—	1
auditory	associated_with	PAU	—	1
Bdnf	associated_with	PAU	2.64e-06	1
brain	associated_with	PAU	—	2
Cadm2	risk_factor_for	PAU	—	2
central nervous system	associated_with	PAU	—	1
cortical neurons	associated_with	PAU	—	1
DGN	associated_with	PAU	—	1
Dopamine D2 receptor	associated_with	PAU	2.64e-06	2
Dopamine D2 receptor	biomarker_for	PAU	—	1
Dopamine D2 receptor	risk_factor_for	PAU	—	2
Dpp6	risk_factor_for	PAU	—	1
East Asian	associated_with	PAU	—	1
EUR	associated_with	PAU	—	1
European ancestry	associated_with	PAU	—	2
European population	associated_with	PAU	—	1
fetal brain	associated_with	PAU	—	1
FinnGen	associated_with	PAU	—	1
FTO	risk_factor_for	PAU	—	1
FUT2	risk_factor_for	PAU	—	1
GCKR	biomarker_for	PAU	—	1
GCKR	risk_factor_for	PAU	—	1
GTEx	associated_with	PAU	—	1
H3K27ac	associated_with	PAU	—	1
H3K4me1	associated_with	PAU	—	1
Hispanic	associated_with	PAU	—	1
iPSYCH	associated_with	PAU	—	1
Klb	risk_factor_for	PAU	—	1
Klb	associated_with	PAU	—	1
MVP	associated_with	PAU	—	1
novel variant	associated_with	PAU	—	1
OPRM1	associated_with	PAU	6.16e-09	1
OPRM1 A118G	risk_factor_for	PAU	—	1
OPRM1 A118G	associated_with	PAU	6.16e-09	1
PAU	associated_with	AFR	—	1
PAU	associated_with	age at smoking initiation	—	1
PAU	risk_factor_for	airflow obstruction	—	1
PAU	associated_with	alcohol	—	1
PAU	risk_factor_for	alcoholic liver disease	—	1
PAU	associated_with	alcohol-related problems	—	1
PAU	associated_with	Alcohol Use Disorder	—	1
PAU	associated_with	Alzheimer's disease	—	2
PAU	associated_with	attention deficit hyperactivity disorder	—	1
PAU	associated_with	auditory	—	2
PAU	associated_with	BioVU	—	1
PAU	associated_with	bipolar disorder	—	1
PAU	associated_with	brain	—	1
PAU	associated_with	brain tissue	—	1
PAU	risk_factor_for	bronchitis	—	1
PAU	associated_with	cognitive traits	—	1
PAU	associated_with	depressive symptoms	—	1
PAU	associated_with	drinks per week	0	1
PAU	associated_with	EA	7.57e-31	1
PAU	associated_with	EUR	—	1
PAU	associated_with	European ancestry	—	1
PAU	associated_with	GSCAN	—	1
PAU	associated_with	GTEx	—	1
PAU	associated_with	insomnia	—	2
PAU	associated_with	lateral amygdala	—	1
PAU	associated_with	LD Hub	—	1
PAU	associated_with	lifetime cannabis use	—	1
PAU	associated_with	major depressive disorder	1.43e-40	2
PAU	associated_with	Mass General Brigham Biobank	—	1
PAU	associated_with	Maximum Habitual Alcohol Intake	0	1
PAU	associated_with	mood disorders	—	1
PAU	associated_with	MVP	—	1
PAU	associated_with	OUD	0	1
PAU	associated_with	Penn Medicine Biobank	—	1
PAU	associated_with	PGC	—	1
PAU	associated_with	psychiatric traits	—	2
PAU	associated_with	risk-taking behavior	—	1
PAU	associated_with	schizophrenia	—	2
PAU	associated_with	smoking phenotypes	—	1
PAU	associated_with	subjective well-being	—	1
PAU	associated_with	substance use	—	2
PAU	associated_with	UKB	—	2
PAU	associated_with	UK Biobank	—	1
Pde4b	risk_factor_for	PAU	—	1
proxy SNPs	associated_with	PAU	5e-08	1
Psychiatric Genomics Consortium	associated_with	PAU	—	1
rare variant	risk_factor_for	PAU	—	1
risk allele	risk_factor_for	PAU	—	2
risk loci	risk_factor_for	PAU	—	1
Roadmap Epigenomics consortium	associated_with	PAU	—	1
rs1229984	risk_factor_for	PAU	—	1
rs1260326	risk_factor_for	PAU	—	1
rs13107325	risk_factor_for	PAU	—	1
rs2066702	risk_factor_for	PAU	—	2
rs3782886	risk_factor_for	PAU	—	1
rs6265	risk_factor_for	PAU	—	1
rs75967634	risk_factor_for	PAU	1.07e-09	2
SIX3	risk_factor_for	PAU	—	1
SLC39A13	risk_factor_for	PAU	—	1
SLC39A8	risk_factor_for	PAU	—	1
South Asian	associated_with	PAU	—	1
S-PrediXcan	associated_with	PAU	—	1
SYNGAP1	associated_with	PAU	2.64e-06	1
THSD7B	risk_factor_for	PAU	—	2
TMX2	risk_factor_for	PAU	—	1
UKB	associated_with	PAU	—	1
UK Biobank	associated_with	PAU	—	2
variant	associated_with	PAU	—	1

Mentioned in (7)

Papers in which this entity is mentioned.

Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. (2025)
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. (2025)
Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder. (2024)
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. (2023)
Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. (2022)
Genetics of substance use disorders in the era of big data. (2021)
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. (2020)

Merged raw entities (2)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
pau	phenotype	7	70
pau meta-analysis	phenotype	—	—