ADH1C associated_with alcohol dependence
Evidence from:
primary |
all sources
Evidence (7 sources)
Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.
(2024)
PMID:38405959
primary
identified three loci previously associated with alcohol dependence —ADH1B, ADH1C, and ADH4
confidence: 0.96
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
(2019)
PMID:31090166
primary
variants within the alcohol metabolizing genes, notably ADH1B, and to a lesser degree, ADH1C, are associated with AD
confidence: 0.85
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
(2016)
PMID:25865819
primary
several known alcohol metabolism genes are located on chromosome 4q23 (ADH4, ADH5, ADH6, ADH1A, ADH1B, ADH1C)... to provide an estimate of polygenic risk for alcohol dependence
confidence: 0.80
Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
(2011)
PMID:21818250
primary
in alcohol dependent to population control samples... identified nine genes. Products of two of these genes, ADH1C and PECR,
confidence: 0.90
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
Genome-wide significant (p < 10–8) and replicable SNPs were located in the following genes ... ADH1C ...
confidence: 0.96
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
(2015)
PMID:26110981
cited
significant associations in alcohol metabolizing enzyme genes
confidence: 0.85
The genetics of alcohol dependence: advancing towards systems-based approaches.
(2012)
PMID:22854292
cited
ADH1C gene ... has over 50 publications linking it to alcohol use/alcoholism/AD
confidence: 0.90