ADH1C associated_with alcohol dependence
Evidence from:
primary |
all sources
Evidence (4 sources)
Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.
(2024)
PMID:38405959
primary
identified three loci previously associated with alcohol dependence —ADH1B, ADH1C, and ADH4
confidence: 0.96
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
(2019)
PMID:31090166
primary
variants within the alcohol metabolizing genes, notably ADH1B, and to a lesser degree, ADH1C, are associated with AD
confidence: 0.85
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
(2016)
PMID:25865819
primary
several known alcohol metabolism genes are located on chromosome 4q23 (ADH4, ADH5, ADH6, ADH1A, ADH1B, ADH1C)... to provide an estimate of polygenic risk for alcohol dependence
confidence: 0.80
Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
(2011)
PMID:21818250
primary
in alcohol dependent to population control samples... identified nine genes. Products of two of these genes, ADH1C and PECR,
confidence: 0.90