cannabis use risk_factor_for psychosis

predictive effect of the interaction between cannabis use and COMT genotype on psychosis

cannabis use at age 14 was associated with psychotic symptoms at age 16 in the Avon Longitudinal Study of Parents and Children

longitudinal studies showing a persisting association between cannabis use and psychosis even after accounting for confounders

cannabis use may cause psychosis via enduring alterations in brain regions

cannabis use precipitates psychosis in individuals with pre-existing vulnerabilities

cannabis exposure activates diathesis to psychosis

cannabis might be viewed as an environmental trigger of genetic vulnerability to an outcome, say psychotic illness

cannabis use can be implicated in the (co)-occurrence of major psychiatric disorders (e.g. ... psychosis)

Cannabis use ... increased risk of ... psychotic ... disorders

cannabis triggering psychosis in vulnerable individuals

Genetic factors moderate the effect of cannabis exposure on the risk for psychosis.

early and heavy cannabis exposure may increase the risk of developing a psychotic disorder

dose-dependent increased risk of psychosis in subjects exposed to cannabis

Attributable risk of cannabis to psychosis was estimated at 50% for cases with psychotic disorders that required psychiatric treatment.

Even fewer develop a psychotic disorder, and other factors must interact with cannabis exposure to increase likelihood.

Whether exposure to cannabis can “cause” a persistent psychotic disorder is less clear.