GAD2 associated_with alcohol dependence
Evidence from:
primary |
all sources
Evidence (3 sources)
Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.
(2016)
PMID:26809998
cited
The functional promoter Gad2-243A>G variant was significantly associated with alcohol dependence in Russian but not European American males.
confidence: 0.85
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
Case-control association analyses for AD were conducted ... for GAD2 ... genes.
confidence: 0.95
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
Among females, several SNPs in GAD2 showed modest association (P = 0.04) with AD
confidence: 0.90