GAD1 regulates GABA
Evidence from:
primary |
all sources
Evidence (6 sources)
Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.
(2016)
PMID:26809998
cited
shunted into GABA synthesis via glutamate decarboxylase (GAD).
confidence: 0.95
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
(2012)
PMID:22253714
cited
These genes encode enzymes that synthesize GABA from glutamate.
confidence: 0.92
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
are responsible for catalyzing glutamate to produce GABA in the brain
confidence: 0.96
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
GAD is the rate-limiting enzyme for synthesis of GABA in the brain
confidence: 0.96
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
Acute response to ethanol ... requires more GAD to transfer glutamic acid to produce GABA.
confidence: 0.85
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
GAD1 is important in maintaining GABA levels in the brain
confidence: 0.95