Chrnb2 associated_with nicotine

Subject: Chrnb2
Relation: associated_with
Object: nicotine
p-value: —

Evidence from: primary | all sources

Evidence (5 sources)

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

implicating its role in mediating nicotine dependence

confidence: 0.96

New insights into the genetics of addiction. (2009) PMID:19238175 cited

epistatic analysis ... revealed that CHRNB2 has a significant effect on ND when analyzed with CHRNA4

confidence: 0.80

New insights into the genetics of addiction. (2009) PMID:19238175 cited

KO mice for nAChR subunits ... β2–β4 have shown that the deletion of these genes alters many effects of nicotine.

confidence: 0.90

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. (2008) PMID:18593715 cited

associations of SNPs in ... nAChR subunit genes with nicotine dependence

confidence: 0.80

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. (2008) PMID:18783506 cited

early smoking experiences may mediate nicotine dependence, involving ... beta-2 subunits ...

confidence: 0.85