COMT Val158Met regulates dopamine

Subject: COMT Val158Met
Relation: regulates
Object: dopamine
p-value: —

Evidence from: primary | all sources

Evidence (1 sources)

COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. (2013) PMID:23459442 cited

high COMT enzyme activity associated with Val allele may reduce tonic DA and increase phasic DA release in subcortical areas.

confidence: 0.90