common variants risk_factor_for psychiatric disorders
Evidence from:
primary |
all sources
Evidence (7 sources)
What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.
(2018)
PMID:30549495
cited
Common gene variants ... play a large role in psychiatric disorders. ... relative risk of ~1.1, or an increase in risk of 10% for carriers
confidence: 0.96
psychiatric disorders are caused by ... common genetic variants each of small effect
confidence: 0.95
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
subsequent GWAS indicated ... detect the small effects of risk loci for the majority of complex traits and disease, especially for psychiatric disorders.
confidence: 0.90
Translating genome-wide association findings into new therapeutics for psychiatry.
(2016)
PMID:27786187
cited
risk is mediated by the cumulative effect of large numbers of common genetic variant ... for most individuals with serious psychiatric disorders
confidence: 0.96
a large proportion of the genetic contribution to psychiatric disease is found to consist of common variants ... each variant has only a small effect on disease risk
confidence: 0.94
Genomewide association studies: history, rationale, and prospects for psychiatric disorders.
(2009)
PMID:19339359
cited
common SNP associations have been discovered for many common disorders... many common SNPs, each with small effects, contributing collectively to a major portion of genetic risk
confidence: 0.93
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
(2009)
PMID:19065143
cited
this is particularly true for psychiatric disorders where sample collection is particularly challenging
confidence: 0.75