Chrna4 risk_factor_for nicotine

Subject: Chrna4
Relation: risk_factor_for
Object: nicotine
p-value: —

Evidence from: primary | all sources

Evidence (7 sources)

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

SNPs or haplotypes of the CHRNA4 gene have been associated with nicotine dependence in family-based analyses ... and in a study evaluating unrelated European Americans and African-Americans.

confidence: 0.90

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

α4 subunit ... essential to the development of the nicotine dependence phenotype

confidence: 0.93

Association of CHRNA4 polymorphisms with smoking behavior in two populations. (2011) PMID:21445957 cited

The gene CHRNA4 ... is a candidate gene for ND risk.

confidence: 0.95

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited

our interpretation ... that these regions are likely to be involved in genetic risk contributing to nicotine dependence

confidence: 0.90

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited

SNPs in or near CHRNA4 ... affect the risk of developing nicotine dependence

confidence: 0.94

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited

"these regions are likely to be involved in genetic risk contributing to nicotine dependence"

confidence: 0.90

New insights into the genetics of addiction. (2009) PMID:19238175 cited

involvement of a few nAChR subunit genes specifically in ND

confidence: 0.80