stressful life events risk_factor_for depression

to the depression-inducing effects of stressful life events

interaction ... predicting depression

stressful life events have a potent relationship with the risk of depression

The only significant finding across studies was the potent association of stressful life events with the risk of depression.

risk of depression increasing with the number of S alleles in the presence of stressful life events

meta-analysis ... reveals a direct association between the number of life events and depression (1 vs 0 stressful life event: OR 1.31; 2 vs 0: OR 1.95; ≥3 vs 0: OR 3.21)

more likely to experience depressive episodes, especially when they face stressful life events.

effect of the number of stressful life events ... on risk of depression

environmental risk factor (stressful life events) ... stratified by the number of stressful life events.

We had 80% power to reject the null hypothesis of no interaction between stressful life events and 5-HTTLPR genotype ...

The meta-analysis showed a significant association for all participants (OR, 1.41; 95% CI, 1.27-1.57)... P value of <.001.

the number of stressful life events was significantly associated with depression (OR, 1.40; 95% CI, 1.25-1.57)

We first examined the association between the number of stressful life events ... with depression as the response variable.