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ALDH2 targets acetaldehyde

Subject
ALDH2
Relation
targets
Object
acetaldehyde
p-value
Evidence from: primary | all sources

Evidence (5 sources)

Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review. (2018) PMID:30167705 cited
aldehyde dehydrogenase, which metabolizes acetaldehyde
confidence: 0.94
Human Genetics of Addiction: New Insights and Future Directions. (2018) PMID:29504045 cited
then to acetate via ALDH enzymes; ALDH2 activity converts acetaldehyde to acetate
confidence: 0.95
Alcohol metabolism and epigenetics changes. (2013) PMID:24313160 cited
metabolized further. This is done mainly by mitochondrial aldehyde dehydrogenase (ALDH2) to form acetate and NADH.
confidence: 0.94
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. (2012) PMID:22348705 cited
Acetaldehyde is oxidized to acetate by aldehyde dehydrogenase (ALDH)
confidence: 0.95
Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007) PMID:17718398 cited
The acetaldehyde produced ... is, in turn, metabolized to acetate in a reaction catalyzed by the aldehyde dehydrogenase (ALDH) enzymes.
confidence: 0.96