CHRNA5 risk_factor_for heavy smoking

Subject: CHRNA5
Relation: risk_factor_for
Object: heavy smoking
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Identification of CHRNA5 rare variants in African-American heavy smokers. (2014) PMID:24682045 cited

a hypo-functional α5 allele ... might be contributing to heavy smoking in a subset of our re-sequenced African-American population

confidence: 0.85

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. (2010) PMID:19896728 cited

genetic studies implicate variants in the chromosome 15q24-25 region ... includes the α5-α3-β4 nicotinic receptor gene cluster ... in the development of heavy smoking.

confidence: 0.95