rs16969968 associated_with European ancestry
Evidence from:
primary |
all sources
Evidence (7 sources)
Identification of CHRNA5 rare variants in African-American heavy smokers.
(2014)
PMID:24682045
cited
rs16969968:G>A has a low minor allele frequency (MAF) in populations other than those of European descent
confidence: 0.80
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
variation explained by the chromosome 15q25 SNPs rs16969968 ... is 1.9% in both EAs and AAs.
confidence: 0.90
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
In EAs, rs16969968 has the highest individual R2 of the SNPs considered (1.4%).
confidence: 0.95
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
at rs16969968 the ... EA odds ratios are not significantly different (heterogeneity p = 0.24)
confidence: 0.90
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
consistent direction of effect of the “A” risk allele in EAs
confidence: 0.92
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
rs16969968 is the most significant of the 76 SNPs in the EAs alone (p = 4.14×10−7, OR = 1.40...).
confidence: 0.96
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
among “CCs” at rs578776, rs16969968 has p = 0.0039, OR = 1.29 (1.09–1.54)
confidence: 0.95