common variants risk_factor_for alcohol dependence
Evidence from:
primary |
all sources
Evidence (5 sources)
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
(2013)
PMID:23607416
primary
significant proportion of variance in AD risk can be explained by common SNPs of small effect
confidence: 0.96
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
(2013)
PMID:23607416
primary
a skew in the R2 distribution towards more common markers... suggesting an important role for highly common variants in the liability of AD (P = 0.0047 for EA; P = 0.00013 for AA)
confidence: 0.94
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
(2013)
PMID:23607416
primary
we aggregated genotypic data ... to test their association to AD, estimating the variance in AD liability accounted by common SNPs
confidence: 0.95
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
(2015)
PMID:26110981
cited
estimates of the variance in AD risk attributable to common variants have been as high as 23%
confidence: 0.90
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
(2015)
PMID:26110981
cited
A related analysis ... (Do et al. 2012), yielded a very similar estimate (i.e., 23.9%).
confidence: 0.95