SLC6A4 risk_factor_for autism
Evidence from:
primary |
all sources
Evidence (2 sources)
The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies.
(2008)
PMID:17987668
cited
Altered serotonergic neurotransmission is hypothesized to be central to the pathogenesis of ... autism ... The serotonin transporter (5HTTor SLC6A4) is a key regulator of serotonergic neurotransmission.
confidence: 0.70
Genetic and environmental factors in complex neurodevelopmental disorders.
(2007)
PMID:19412416
cited
the serotonin transporter gene (SLC6A4) on chromosome 17q11.1-q12 has been studied via the candidate-gene approach, but no gene has been found to clearly contribute to autism susceptibility
confidence: 0.60