SLC6A4 risk_factor_for major depressive disorder

Subject: SLC6A4
Relation: risk_factor_for
Object: major depressive disorder
p-value: —

Evidence from: primary | all sources

Evidence (1 sources)

The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. (2008) PMID:17987668 cited

Altered serotonergic neurotransmission is hypothesized to be central to the pathogenesis of ... major depression ... The serotonin transporter (5HTTor SLC6A4) is a key regulator of serotonergic neurotransmission.

confidence: 0.70