nicotine interacts_with Chrnb2

Subject: nicotine
Relation: interacts_with
Object: Chrnb2
p-value: —

Evidence from: primary | all sources

Evidence (6 sources)

Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. (2021) PMID:32333417 cited

nicotine binds and activates ... β2-nicotinic acetylcholine receptors (nAChR)

confidence: 0.96

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

nicotine‑stimulated dopamine release ... implicating its role ... β2 subunit

confidence: 0.90

Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. (2011) PMID:21079997 cited

biologically active receptors that bind nicotine

confidence: 0.90

New insights into the genetics of addiction. (2009) PMID:19238175 cited

nicotine exerts its biological function by binding to nAChRs, which are composed of five subunits

confidence: 0.70

Protein kinases and addiction. (2008) PMID:18991950 cited

Acute nicotine treatment desensitizes α4β2 nACh receptors

confidence: 0.85

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. (2008) PMID:18593715 cited

nicotine from a single cigarette nearly completely saturates α4β2 nAChRs

confidence: 0.95