ROS regulates NLRP3

increased mitochondrial production of ROS stimulated NLRP3

ROS could directly oxidize thiol groups in the LRR domain of NLRP3 and ... activate the inflammasomal pathway.

The increased level of reactive oxygen species (ROS) induced by oxidative stress was one of the first stimuli which was demonstrated to trigger NLRP3 activation.

NLRP3 activation was ROS-dependent

ROS-dependent activation of NLRP3 inflammasomes