CHRNA5 associated_with lung cancer

Subject: CHRNA5
Relation: associated_with
Object: lung cancer
p-value: —

Evidence from: primary | all sources

Evidence (7 sources)

Genetics of substance use disorders in the era of big data. (2021) PMID:34211176 cited

CHRNA5–CHRNA3–CHRNB4 variants showed associations with ... lung cancer

confidence: 0.93

Human Genetics of Addiction: New Insights and Future Directions. (2018) PMID:29504045 cited

CHRNA5 with lung cancer (most recently [34]), lung function [35], airflow obstruction [36], COPD (most recently [37]), and peripheral arterial disease [9]

confidence: 0.95

G = E: What GWAS Can Tell Us about the Environment. (2016) PMID:26866486 cited

the same region was shown to be associated with lung cancer risk

confidence: 0.88

Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009) PMID:19247474 cited

region ... spanning ... CHRNA5 ... identified in genome-wide association scans of lung cancer

confidence: 0.93

New insights into the genetics of addiction. (2009) PMID:19238175 cited

strong association between variants of CHRNA5/A3/B4 ... and lung cancer

confidence: 0.95

Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. (2009) PMID:19132693 cited

CHRNA5 ... associations of these genes with ... lung cancer ...

confidence: 0.90

New insights into the genetics of addiction. (2009) PMID:19238175 cited

Variants of the CHRNA5/A3/B4 cluster ... were found ... to be associated ... with lung cancer as well.

confidence: 0.96