ALDH2 protective_against alcoholism

Subject: ALDH2
Relation: protective_against
Object: alcoholism
p-value: —

Evidence from: primary | all sources

Evidence (3 sources)

The genetic basis of addictive disorders. (2012) PMID:22640768 cited

variants ... are protective against alcoholism

confidence: 0.93

Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007) PMID:17718398 cited

ALDH2*2 ... protects people from developing alcoholism

confidence: 0.94

The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (2007) PMID:17718394 cited

Coding variants in both of these genes are strongly protective.

confidence: 0.94