glutamate risk_factor_for excitotoxicity

Subject: glutamate
Relation: risk_factor_for
Object: excitotoxicity
p-value: —

Evidence from: primary | all sources

Evidence (3 sources)

Efficient derivation of microglia-like cells from human pluripotent stem cells. (2016) PMID:27668937 cited

Glutamate was omitted to avoid the excitotoxicity of this amino‑acid in dissociated cultures.

confidence: 0.95

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. (2016) PMID:26809998 cited

excessive glutamate in the synapse ... can lead to excitotoxicity

confidence: 0.96

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. (2016) PMID:26809998 cited

excessive extracellular glutamate ... neuronal damage induced by excitotoxicity

confidence: 0.90