GRM8 risk_factor_for alcohol dependence
Evidence from:
primary |
all sources
Evidence (3 sources)
Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.
(2009)
PMID:18618593
primary
disturbance ... mediated by mGluR8 may be involved in the pathophysiology of alcohol dependence
confidence: 0.90
Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.
(2009)
PMID:18618593
primary
It is also the first report identifying a positive association between the GRM8 and alcohol dependence.
confidence: 0.94
Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.
(2016)
PMID:26809998
cited
multiple polymorphisms of the mGlu8 gene are significantly associated with ... a genetic risk to develop alcoholism
confidence: 0.90