CHRNA5 risk_factor_for lung cancer
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Evidence (8 sources)
CHRNA5 ... influence susceptibility of developing smoking-related health outcomes, including: CHRNA5 with lung cancer
confidence: 0.94
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
(2011)
PMID:21278726
cited
high incidence of lung cancer ... in individuals carrying CHRNA5 risk alleles
confidence: 0.95
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
the α5 nicotinic receptor subunit gene ... as the most likely gene altering the risk for ... lung cancer...
confidence: 0.90
CHRNA5/A3/B4 cluster as a susceptibility locus for ... lung cancer
confidence: 0.95
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
(2009)
PMID:19654303
cited
same alleles at this locus increased risk of lung cancer; CHRNA5 is one of the genes mapping to this region
confidence: 0.90
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
(2008)
PMID:18783506
cited
risk of ... lung cancer is associated with a group of genes ... coding for alpha-5 ... subunits
confidence: 0.95
One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility.
(2008)
PMID:18936755
cited
α3/α5/β4-linked variations could contribute to increased risk of ... lung cancer
confidence: 0.94
One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility.
(2008)
PMID:18936755
cited
same locus as a modulator of susceptibility for lung cancer
confidence: 0.90