CYP2A6 regulates nicotine

Subject: CYP2A6
Relation: regulates
Object: nicotine
p-value: —

Evidence from: primary | all sources

Evidence (3 sources)

Identification of CHRNA5 rare variants in African-American heavy smokers. (2014) PMID:24682045 cited

may influence smoking status by affecting nicotine metabolism

confidence: 0.88

The co-occurring use and misuse of cannabis and tobacco: a review. (2012) PMID:22300456 cited

genetic variants in CYP2A6 ... involved in the oxidation of nicotine

confidence: 0.95

Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. (2011) PMID:21862624 cited

CYP2A6 - the major enzyme involved in the metabolism of nicotine.

confidence: 0.95