NEGR1 expressed_in hypothalamus

Subject: NEGR1
Relation: expressed_in
Object: hypothalamus
p-value: 3.19e-25

Evidence from: primary | all sources

Evidence (4 sources)

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. (2021) PMID:34045744 cited

Top genes for each tissue tested were: hypothalamus (NEGR1, p=3.19×10−25)

confidence: 0.97

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. (2021) PMID:34045744 cited

S-MultiXcan analysis prioritized hypothalamus as related to NEGR1.

confidence: 0.85

Implication of European-derived adiposity loci in African Americans. (2012) PMID:21750520 cited

These loci are all highly expressed in the brain (and several especially in the hypothalamus).

confidence: 0.98

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (2009) PMID:19079261 cited

NEGR1 ... are expressed at high levels in hypothalamus

confidence: 0.95