Collaborative Study on the Genetics of Alcoholism (COGA) associated_with auditory

COGA is a high-risk sample, with most participants from extended families enriched for AUD.

families densely affected with AUD

datasets enriched for specific clinical outcomes, such as the COGA data enriched for AUD

COGA's ability to chart the etiology and course of ... AUD across the lifecourse.

COGA data have contributed towards advancing our understanding of the etiology, course and consequences of AUD

we approach our contributions to the study of AUD ...

COGA ... contributed to some of the first GWAS of AUD.

COGA has collected multimodal data, primarily from families that are densely affected with AUD

The design of COGA ... was enriched for AUD liability ...

genetic differences in COGA participants are now being translated ... potentially leading to novel therapeutic strategies for treating AUD

COGA ... focused on longitudinal data collection of those ... alcohol use, AUD and remission

how does AUD emerge and manifest in families... our multi‑modal data framework... risk and resilience to AUD over the lifespan increases

studying the lifecourse of AUD in families ... integrated data collection and analyses of COGA

A notable contribution of COGA's family design has been to disentangle antecedents of, and predisposition to AUD from its sequelae.

development of comorbid disorders in the relatives of COGA probands, including AUD ... has been established

signal for rs1229984 was also noted in our COGA GWAS.