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SLC6A4 risk_factor_for depression

Subject
SLC6A4
Relation
risk_factor_for
Object
depression
p-value
—
Evidence from: primary | all sources

Evidence (9 sources)

Candidate gene-environment interaction research: reflections and recommendations. (2015) PMID:25620996 primary
attributing part of the genetic sensitivity to the depressogenic effects ... to variations in ... 5-HTTLPR
confidence: 0.95
Gene-environment interaction in psychological traits and disorders. (2011) PMID:21219196 primary
interactions between the 5-HTT gene, life events, and depression ... occurred at the extreme low ends of the environmental measures
confidence: 0.92
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015) PMID:26250693 cited
developmental effect of SLC6A4 genotype on susceptibility to anxiety, depression, and regional brain connectivity in adulthood.
confidence: 0.88
Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression. (2014) PMID:24939753 cited
individuals with an at-risk serotonin transporter genotype are likely to develop depression after life stress
confidence: 0.90
The serotonin transporter gene and startle response during nicotine deprivation. (2011) PMID:20888887 cited
robust relationships between the 5-HTTLPR gene and depression have been reported only in the presence of high levels of environmental stress
confidence: 0.90
The serotonin transporter gene and startle response during nicotine deprivation. (2011) PMID:20888887 cited
The 5-HTTLPR has been linked to ... depression ...
confidence: 0.80
An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. (2011) PMID:34385894 cited
interaction between a polymorphism in the serotonin transporter gene and stressful life events in the development of depression
confidence: 0.95
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. (2009) PMID:19531786 cited
association between the (1) 5-HTTLPR genotype ... and ... categorical measure of depression defined by DSM-IV or ICD-10
confidence: 0.95
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. (2009) PMID:19531786 cited
effect of 5-HTTLPR genotype ... on risk of depression
confidence: 0.95