Chrna3 risk_factor_for nicotine
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Evidence (11 sources)
360 SNPs in the CHRNA5-CHRNA3-CHRNB4 locus were significantly associated ... nicotine dependence
confidence: 0.96
implicating ... CHRNA3 ... which have since been firmly established ... in studies of nicotine dependence
confidence: 0.90
Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use.
(2015)
PMID:25690561
cited
Variants of these genes have been associated with risk for nicotine dependence
confidence: 0.90
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
genetic studies implicate variants in the chromosome 15q24-25 region ... includes the α5-α3-β4 nicotinic receptor gene cluster ... in the development of ... nicotine dependence.
confidence: 0.95
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
The most plausible genes that may influence smoking behavior in this region are the family of nicotinic receptor genes.
confidence: 0.92
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
multiple cholinergic nicotinic receptor genes ... CHRNA5-CHRNA3-CHRNB4 ... are involved in nicotine dependence risk
confidence: 0.93
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
variants in several nicotinic receptor subunit genes ... affect the risk of developing nicotine dependence
confidence: 0.96
involvement of a few nAChR subunit genes specifically in ND
confidence: 0.80
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
The CHRNA5-CHRNA3-CHRNB4 region clearly plays a role in nicotine dependence risk
confidence: 0.96
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.
(2009)
PMID:19132693
cited
the α5 and α3 genes are established as one of the best replicated genes imposing risks to ... nicotine dependence
confidence: 0.95
One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility.
(2008)
PMID:18936755
cited
α3/α5/β4-linked variations could contribute to increased risk of nicotine dependence
confidence: 0.95