Chrnb4 risk_factor_for nicotine

Subject: Chrnb4
Relation: risk_factor_for
Object: nicotine
p-value: —

Evidence from: primary | all sources

Evidence (10 sources)

Human Genetics of Addiction: New Insights and Future Directions. (2018) PMID:29504045 cited

360 SNPs in the CHRNA5-CHRNA3-CHRNB4 locus were significantly associated ... nicotine dependence

confidence: 0.96

Human Genetics of Addiction: New Insights and Future Directions. (2018) PMID:29504045 cited

implicating ... CHRNB4 ... which have since been firmly established ... in studies of nicotine dependence

confidence: 0.90

Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use. (2015) PMID:25690561 cited

Variants of these genes have been associated with risk for nicotine dependence

confidence: 0.90

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited

variants in several nicotinic receptor subunit genes ... affect the risk of developing nicotine dependence

confidence: 0.96

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. (2010) PMID:19896728 cited

The most plausible genes that may influence smoking behavior in this region are the family of nicotinic receptor genes.

confidence: 0.92

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. (2010) PMID:19896728 cited

genetic studies implicate variants in the chromosome 15q24-25 region ... includes the α5-α3-β4 nicotinic receptor gene cluster ... in the development of ... nicotine dependence.

confidence: 0.95

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited

multiple cholinergic nicotinic receptor genes ... CHRNA5-CHRNA3-CHRNB4 ... are involved in nicotine dependence risk

confidence: 0.93

New insights into the genetics of addiction. (2009) PMID:19238175 cited

involvement of a few nAChR subunit genes specifically in ND

confidence: 0.80

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. (2009) PMID:19706762 cited

The CHRNA5-CHRNA3-CHRNB4 region clearly plays a role in nicotine dependence risk

confidence: 0.96

One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility. (2008) PMID:18936755 cited

α3/α5/β4-linked variations could contribute to increased risk of nicotine dependence

confidence: 0.95